TITLE

Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB × NZWF[sub 1] mice

AUTHOR(S)
Hasegawa, K.; Hayashi, T.
PUB. DATE
November 2003
SOURCE
Lupus;2003, Vol. 12 Issue 11, p838
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB × NZWF[sub 1] (B/WF[sub 1]) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease began at the age of six months and progressed linearly at the age of 6.75 months in CpG-ODN-treated, but not control ODN-treated (control) groups. Also compared to control group, CpG-ODN-treated mice exhibited a severe glomerulonephritis (GN), with prominent deposits of IgG2a and C3, which paralleled increased titre of IgG2a type anti-nuclear antibody in the blood. Among several cytokines (interleukin, IL-6, IL-4, IL-1α, IL-10, interferon-γ and tumor necrosis factor-α) in blood, IL-6 production paralleled the development of lupus nephritis. The present study suggests that CpG-ODN may enhance IL-6 production. The role of IL-6 in the development of GN will be discussed.
ACCESSION #
11351477

 

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