TITLE

�-Lactamases and their Inhibitors: An Update

AUTHOR(S)
Micetich, R.G.; Salama, S.M.; Maiti, S.N.; Reddy, A.V.N.; Singh, R.
PUB. DATE
July 2002
SOURCE
Current Medicinal Chemistry - Anti-Infective Agents;Jul2002, Vol. 1 Issue 3, p193
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The �-lactam antibiotics perhaps form the best studied and most used (in volume and sales) antibiotics in the world today. The extensive and in many cases, uncontrolled use of the �-lactam antibiotics, particularly in developing countries and for veterinary uses, has resulted in the evolution of resistance in many strains of bacteria. One common mechanism of resistance with �-lactam antibiotics is the expression of a specific class of enzymes - the �-lactamases - by the bacteria. These enzymes interact with and destroy the antibiotic, before it can exert its desired effect. Many (up to now 340) distinct �-lactamases have been isolated and identified so far and various methods of classifying them reported. The particular �-lactamases produced is dependent on factors that include the nature of the strain of bacteria and the particular antibiotic used. Since over the years, the usage of the �-lactam antibiotics has changed depending on the discovery of new and superior members and on variations in usage in different countries, there has been a shifting pattern in the particular �-lactamases produced over time. There is hence a continuing need to identify new �-lactamases inhibitors which would be effective in combination with the newer antibiotics. This paper considers recent developments in identifying new classes and members of �-lactamase inhibitors.
ACCESSION #
11333018

 

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