TITLE

N-Thiolated �-Lactams

AUTHOR(S)
Long, T.E.; Turos, E.
PUB. DATE
July 2002
SOURCE
Current Medicinal Chemistry - Anti-Infective Agents;Jul2002, Vol. 1 Issue 3, p251
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
N-Thiolated �-lactams are �-lactam compounds that have a sulfur substituent on the nitrogen center. They represent a broad and growing family of bioactive molecules. In this review we provide a summary of the known biological properties of the different classes of N-thiolated �-lactams, and the methods used to prepare them. Our discussion begins with the N-sulfonic acid derivatives, which include the well-known monobactam family of antibiotics, followed by the N-sulfonyl, N-sulfinyl, and N-sulfenyl �-lactams.
ACCESSION #
11333015

 

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