TITLE

Power of Selective Genotyping in Genetic Association Analyses of Quantitative Traits

AUTHOR(S)
Van Gestel, Sofie; Houwing-Duistermaat, Jeanine J.; Adolfsson, Rolf; van Duijn, Cornelia M.; Van Broeckhoven, Christine
PUB. DATE
March 2000
SOURCE
Behavior Genetics;Mar2000, Vol. 30 Issue 2, p141
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A power calculation is described in which the power of selective genotyping in genetic association studies of quantitative traits is evaluated. The method of selective genotyping implies the selection of the extremely high and low scoring individuals from the continuous distribution of a quantitative trait. The selected individuals are genotyped and association is tested. In the power calculation the following parameters are varied: total sample size of the phenotyped group (1000, 1500, 2000); selection of extremely high and low scoring individuals (2.5%, 5%, 10%); allele frequency of the risk increasing allele (0.10 to 0.90); mode of inheritance and proportion of variance explained by the quantitative trait locus (QTL) (??^2 = 0.01, 0.05, 0.10). We conclude that the method of selective genotyping is a powerful method to detect association for a quantitative trait.
ACCESSION #
11304847

 

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