Power of Selective Genotyping in Genetic Association Analyses of Quantitative Traits

Van Gestel, Sofie; Houwing-Duistermaat, Jeanine J.; Adolfsson, Rolf; van Duijn, Cornelia M.; Van Broeckhoven, Christine
March 2000
Behavior Genetics;Mar2000, Vol. 30 Issue 2, p141
Academic Journal
A power calculation is described in which the power of selective genotyping in genetic association studies of quantitative traits is evaluated. The method of selective genotyping implies the selection of the extremely high and low scoring individuals from the continuous distribution of a quantitative trait. The selected individuals are genotyped and association is tested. In the power calculation the following parameters are varied: total sample size of the phenotyped group (1000, 1500, 2000); selection of extremely high and low scoring individuals (2.5%, 5%, 10%); allele frequency of the risk increasing allele (0.10 to 0.90); mode of inheritance and proportion of variance explained by the quantitative trait locus (QTL) (??^2 = 0.01, 0.05, 0.10). We conclude that the method of selective genotyping is a powerful method to detect association for a quantitative trait.


Related Articles

  • Embrace your personality. Nettle, Daniel // New Scientist;2/9/2008, Vol. 197 Issue 2642, p36 

    The article examines behavioral, social, and genetic research on the five major personality traits and how they affect individuals in various situations. Neuroscientists and psychologists work together to understand how unique personalities are created in the human brain. Studies of personality...

  • Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects. Ulgen, Ayse; Zhihua Han; Wentian Li // BMC Genetics;2003 Supplement 1, Vol. 4, pS60 

    Background: We address the question of whether statistical correlations among quantitative traits lead to correlation of linkage results of these traits. Five measured quantitative traits (total cholesterol, fasting glucose, HDL cholesterol, blood pressure, and triglycerides), and one derived...

  • Genome-wide linkage scan on estimated breeding values for a quantitative trait. Zabaneh, Delilah; Mackay, Ian J. // BMC Genetics;2003 Supplement 1, Vol. 4, pS61 

    Background: A genome-wide linkage scan was performed on Replicate 1 of the simulated data for fasting triglyceride levels. The aim of this study was to implement mixed-model methodology to estimate breeding values for each individual for this trait and to assess the merit of these breeding...

  • A genetic analysis of the relationship between life-history variation and heat-shock tolerance in Drosophila buzzatii. Krebs, Robert A.; Loeschcke, Volker // Heredity;Jul99, Vol. 83 Issue 1, p46 

    Although exposure to environmental stress is common in most populations, and the physiological effects of stress on individuals are well studied, the evolutionary importance of stress to populations is not well understood. To address multitrait responses to environmental change and potential...

  • Analysing complex genetic traits with chromosome substitution strains. Nadeau, Joseph H.; Singer, Jonathan B.; Matin, Angabin; Lander, Eric S. // Nature Genetics;Mar2000, Vol. 24 Issue 3, p221 

    Many valuable animal models of human disease are known and new models are continually being generated in existing inbred strains,. Some disease models are simple mendelian traits, but most have a polygenic basis. The current approach to identifying quantitative trait loci (QTLs) that underlie...

  • The genetic variance for multiple linked quantitative trait loci conditional on marker information in a crossed population. Matsuda, H.; Iwaisaki, H. // Heredity;Jan2002, Vol. 88 Issue 1, p2 

    Examines the genetic variance for multiple linked quantitative trait loci (QTL) conditional on market information in a crossed population. Assessment of the variance of QTL in chromosomal segment; Application of the concept of the expectation of identity-by-descent proportion; Approximation to...

  • Contribution of maternal effect QTL to genetic architecture of early growth in mice. Wolf, J.B.; Vaughn, T.T.; Pletscher, L.S.; Cheverud, J.M. // Heredity;Oct2002, Vol. 89 Issue 4, p300 

    Existing approaches to characterizing quantitative trait loci (QTL) utilize a paradigm explicitly focused on the direct effects of genes, where phenotypic variation among individuals is mapped onto genetic variation of those individuals. For many characters, however, the genotype of the mother...

  • Implications of political expertise in canidate trait evaluations. Funk, Carolyn L. // Political Research Quarterly;Sep97, Vol. 50 Issue 3, p675 

    Examines how trait information is integrated into global candidate evaluation. How is candidate evaluation determined; Impact of trait images on global judgment; Results from the examination.

  • You're Contagious! Woolston, Chris // Men's Health;May2010, Vol. 25 Issue 4, p74 

    The article offers information on several studies which found that friends' trait influence one's health and emotional behavior.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics