Effect of a High Saturated Fat and no-Starch Diet on Serum Lipid Subfrations in Patients With Documented Atherosclerotic Cardiovascular Disease

Hays, James H.; DiSabatino, Angela; Gorman, Robert T.; Vincent, Simi; Stillabower, Michael E.
November 2003
Mayo Clinic Proceedings;Nov2003, Vol. 78 Issue 11, p1331
Academic Journal
• Objective: To determine whether a diet of high saturated fat and avoidance of starch (HSF-SA) results in weight loss without adverse effects on serum lipids in obese nondiabetic patients. • Patients and Methods: Twenty-three patients with atherosclerotic cardiovascular disease participated in a prospective 6-week trial at the Christiana Care Medical Center in Newark, Del, between August 2000 and September 2001. All patients were obese (mean ± SD body mass index [BMI], 39.0 ± 73 kg/m²) and had been treated with statins before entry in the trial. Fifteen obese patients with polycystic ovary syndrome (BMI, 36.1 ± 9.7 kg/m²) and 8 obese patients with reactive hypoglycemia (BMI, 46.8 ± 10 kg/m²) were monitored during an HSF-SA diet for 24 and 52 weeks, respectively, between 1997 and 2000. • Results: In patients with atherosclerotic cardiovascular disease, mean ± SD total body weight (TBW) decreased 52% ± 23% (P<.001) as did body fat percentage (P=.02). Nuclear magnetic resonance spectroscopic analysis of lipids showed decreases in total triglycerides (P<.001), very low-density lipoprotein (VLDL) triglycerides (P<.001), VLDL size (P<.001), large VLDL concentration (P<.001), and medium VLDL concentration (P<.001). High-density lipoprotein (HDL) and LDL concentrations were unchanged, but HDL size (P=.01) and LDL size (P=.02) increased. Patients with polycystic ovary syndrome lost 143% ± 203% of TBW (P=.008) and patients with reactive hypoglycemia lost 19.9% ± 8.7% of TBW (P<.001) at 24 and 52 weeks, respectively, without adverse effects on serum lipids. • Conclusion: An HSF-SA diet results in weight loss after 6 weeks without adverse effects on serum lipid levels verified by nuclear magnetic resonance, and further weight loss with a lipid-neutral effect may persist for up to 52 weeks.


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