Drăguţ, Ramona Maria; Rusu, Emilia; Nan, Raluca; Rusu, Florin; Enache, Georgiana; Grosu, Larisa; Popescu, Horaţiu; Posea, Mihaela; Grosu, Irina; Costache, Adrian; Homencovschi, Corina; Radulian, Gabriela
February 2015
Internal Medicine / Medicina Interna;feb2015, Vol. 12 Issue 1, p13
Academic Journal
The objective of this study was to evaluate cardiovascular risk in patients with metabolic syndrome and to assess the relationship between inflammatory markers, represented by adipokines, and cardiovascular risk in these patients. Material and methods. This cross-sectional and observational study, held in the National Institute of Diabetes, Nutrition and Metabolic Diseases "N. C. Paulescu", Bucharest, included a total of 161 patients in different stages of glucose tolerance. We followed anthropometric indices (weight, height, waist circumference, BMI (body mass index)). The biochemical parameters followed were fasting plasma glucose, glycosylated hemoglobin, lipid profile, liver profile, blood counts, cytokines (adiponectin, IL-6, leptin, resistin and TNF-α). For each patient, the cardiovascular risk was calculated using the UKPDS software (The United Kingdom Prospective Diabetes Study). Insulin resistance was determined by using HOMA-IR (Homeostasis model assessment of insulin resistance). MetS (metabolic syndrome) was defined according to the International Diabetes Federation. Results. MetS was present in 64% (n=103) of patients. Mean age was 50.5±9.1 years, accounting 52.8% women (n=85) and mean duration of diabetes was 7.7±4.6 years. Using the UKPDS-CHD score, 27.3% (n=44) and 16.8% (n=27) of patients had moderate and high risk for cardiovascular disease. The average concentrations of proinflammatory cytokines (TNF-a=13.58 pg/ml, IL-6=14.26 pg/ml, leptin=16.38 ng/ml and resistin=19.86 ng/ml) were higher in patients who have had an UKPDS -CHD score higher than 30 (p <0.001). In these patients was a higher level of TNF-a, which correlates with inflammation degree, but also with insulin resistance. Conclusions. Metabolic syndrome has a high prevalence in patients with type 2 diabetes, increasing the risk of cardiovascular disease. Additional strategies should be implemented to identify and treat patients with metabolic syndrome in order to prevent cardiovascular disease.


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