The Effect of Basal Analog Insulin on the Glycemic Variability in Type 2 Diabetics

Cander, Soner; Gül, Özen Öz; Dizdar, Oğuzhan Sıtkı; Aydın, Taner; Ersoy, Canan
June 2014
Turkish Journal of Endocrinology & Metabolism;6/1/2014, Vol. 18 Issue 2, p33
Academic Journal
Purpose: The aim of this study was to investigate the effect of insulin detemir and glargine on glycemic variability as determined by capillary blood glucose measurements in Type 2 diabetics treated with oral antidiabetic drugs. Material and Method: A total of 64 insulin-naive type 2 diabetics with a HbA1c level of 7.5%-10% were included in the study. The patients were randomized into 3 groups according to the basal insulin analog started; Group 1 (n=22) was started on once-daily detemir, Group 2 (n=22) twicedaily detemir, and Group 3 (n=20) insulin glargine. Basal insulin doses were titrated according to the morning/evening fasting capillary blood glucose levels. Standard deviations of the 8-point intraday fasting and postprandial blood glucose values were compared. Results: The fasting blood glucose intraday standard deviation values showed an improvement of 22.4% in Group 1, 21.4% in Group 2, and 26.4% in Group 3, while the intraday standard deviation for the postprandial values showed an improvement of 14.4%, 15.2%, and 38.7%, respectively (p>0.05). The standard deviation values did not show statistical significance when the groups were compared with each other. Baseline HbA1c values and insulin doses negatively correlated with the glycemic variability. Dicussion: Basal insulin added to treatment in Type 2 diabetics provided an improvement of 14.4% to 38.7% in glycemic variability. There was no significant difference between insulin glargine and detemir regarding this effect.


Related Articles

  • The Effect of Multimodal Exercise Training Program in Subject with Type 2 Diabetes Mellitus. Acar, Serap; Malkoç, Mehtap; Çalan, Mehmet; Çımrın, Dilek; Gedik, Arzu; Bayraktar, Fırat // Turkish Journal of Endocrinology & Metabolism;9/1/2014, Vol. 18 Issue 3, p67 

    Purpose: The aim of our research was to investigate the effect of multimodal aerobic, resistance and flexibility exercise training program on cardiovascular disease risk factor related with exercise capacity, lipid profile, flexibility, body composition, and glycemic control in newly diagnosed...

  • Insulin Resistance in Non-Obese Polycystic Ovary Syndrome Subjects and Relation with Family History of Diabetes Mellitus. Bozkırlı, Emre; Bakıner, Okan; Ertörer, Eda; Anaforoğlu, İnan; Tütüncü, Neslihan Başçıl; Güvener Demirağ, Nilgün // Turkish Journal of Endocrinology & Metabolism;6/1/2015, Vol. 19 Issue 2, p55 

    Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women in reproductive age. Conflicting results are reported in the studies examining insulin resistance in lean PCOS subjects. We aimed to observe the controversial presence of insulin resistance in lean PCOS...

  • No Relationship between Osteocalcin and the Microvascular Complications of Type 2 Diabetes. Küçükler, Ferit Kerim; Bardak, Simge; Çelik, Tuğrul; Tütüncü, Yasemin; Akbaba, Gülhan; Işık, Serhat; Karaahmetoğlu, Selma; Eskioğlu, Erdal; Berker, Dilek; Güler, Serdar // Turkish Journal of Endocrinology & Metabolism;12/1/2014, Vol. 18 Issue 4, p126 

    Purpose: Osteocalcin, one of the osteoblast-specific proteins is produced and secreted by osteoblasts. Although osteocalcin has been thought to play a role only in bone formation, recent studies have shown that it also enhances insulin sensitivity and insulin secretion from pancreatic beta...

  • General Practitioners' Knowledge and Clinical Practice in Management of People with Type 2 Diabetes in Iran; The Impact of Continuous Medical Education Programs. Aghili, Rokhsareh; Malek, Mojtaba; Baradaran, Hamidreza; Peyvandi, Ali Asghar; Valojerdi, Ameneh Ebrahim; Khamseh, Mohammad Ebrahim // Archives of Iranian Medicine (AIM);Sep2015, Vol. 18 Issue 9, p582 

    Background: To obtain information related to the knowledge and clinical practice of general practitioners (GPs) in management of people with type 2 diabetes, and to explore the impact of formal continuous medical education (CME) programs. Methods: A total of 1104 GPs participated in a cross...

  • Glycaemic control: Predictors in T2D.  // Diabetes Digest;2012, Vol. 11 Issue 3, p140 

    The article presents a brief summary of a study conducted by A. Nagrebetsky and colleagues to investigate the suboptimal predictors of glycaemic control in patients with type 2 diabetes.

  • Younger adult type 2 diabetic patients have poorer glycaemic control: a cross-sectional study in a primary care setting in Singapore. Quah, Joanne Hui Min; Yan Ping Liu; Nan Luo; Choon How How; Ee Guan Tay // BMC Endocrine Disorders;2013, Vol. 13 Issue 1, p18 

    Background: The aim was to study the glycaemic control of type 2 diabetic patients, and to identify factors associated with unacceptable glycaemic control (defined as HbA1c >8.0%). Methods: Analysis of data collected in a cross-sectional survey of type 2 diabetic patients in eight SingHealth...

  • Dapagliflozin: A Once-Daily Oral Therapy Sodium-Glucose Cotransporter-2 Inhibitor for the Treatment of Adult Patients with Type 2 Diabetes. Jadoon, Khalid; Idris, Iskandar // Clinical Medicine Insights: Therapeutics;2011, Issue 3, p185 

    The induction of glycosuria using phlorizin, a nonselective inhibitor of renal and intestinal transport was well recognised to lower glucose levels and induce calorie loss in animal models of diabetes. Phlorizin and other similar molecules however were not suitable for clinical use due to...

  • Re-Training of Type 2 Diabetic Patients for Better Adherence to Diabetes Care Plan in Oral Anti-Diabetics and Plus Insulin Treatment Groups. Cander, Soner; Öz Gül, Özen; Gül, Cuma Bülent; Yavaş, Sibel; Ersoy, Canan // Turkish Journal of Endocrinology & Metabolism;6/1/2015, Vol. 19 Issue 2, p49 

    Purpose: This prospective observational single-centre study was designed to evaluate the effect of patient re-training for better adherence to regular self-monitoring of blood glucose (SMBG), standard diabetic diet and exercise program in ambulatory patients with type 2 diabetes mellitus (T2DM)...

  • Therapy type affects weight increase.  // Diabetes Digest;2012, Vol. 11 Issue 2, p86 

    The article discusses a study to evaluate weight change in people with type 2 diabetes (T2D) and the impact of alternative anti-hyperglycemic drugs, which revealed that there was a continual increase in body weight in people with T2D.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics