TITLE

The Effect of Basal Analog Insulin on the Glycemic Variability in Type 2 Diabetics

AUTHOR(S)
Cander, Soner; Gül, Özen Öz; Dizdar, Oğuzhan Sıtkı; Aydın, Taner; Ersoy, Canan
PUB. DATE
June 2014
SOURCE
Turkish Journal of Endocrinology & Metabolism;6/1/2014, Vol. 18 Issue 2, p33
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: The aim of this study was to investigate the effect of insulin detemir and glargine on glycemic variability as determined by capillary blood glucose measurements in Type 2 diabetics treated with oral antidiabetic drugs. Material and Method: A total of 64 insulin-naive type 2 diabetics with a HbA1c level of 7.5%-10% were included in the study. The patients were randomized into 3 groups according to the basal insulin analog started; Group 1 (n=22) was started on once-daily detemir, Group 2 (n=22) twicedaily detemir, and Group 3 (n=20) insulin glargine. Basal insulin doses were titrated according to the morning/evening fasting capillary blood glucose levels. Standard deviations of the 8-point intraday fasting and postprandial blood glucose values were compared. Results: The fasting blood glucose intraday standard deviation values showed an improvement of 22.4% in Group 1, 21.4% in Group 2, and 26.4% in Group 3, while the intraday standard deviation for the postprandial values showed an improvement of 14.4%, 15.2%, and 38.7%, respectively (p>0.05). The standard deviation values did not show statistical significance when the groups were compared with each other. Baseline HbA1c values and insulin doses negatively correlated with the glycemic variability. Dicussion: Basal insulin added to treatment in Type 2 diabetics provided an improvement of 14.4% to 38.7% in glycemic variability. There was no significant difference between insulin glargine and detemir regarding this effect.
ACCESSION #
111574472

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics