TITLE

MicroRNA-495 suppresses human renal cell carcinoma malignancy by targeting SATB1

AUTHOR(S)
Cai Lv; Zhiming Bai; Zhenxiang Liu; Pengcheng Luo; Jie Zhang
PUB. DATE
December 2015
SOURCE
American Journal of Translational Research;2015, Vol. 7 Issue 10, p1992
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Deregulated expression of miRNAs is related to progression and initiation of human cancers. Although miR-495 has identified in various tumors, its expression and function in renal cell carcinoma (RCC) is still unknown. In this study, we found that the expression of miR-495 was downregulated in RCC cell lines and tissues. Ectopic expression of miR-495 induced G0/G1 phase arrest and suppressed cell proliferation and migration in RCC cell lines. We further validated SATB1 was a direct target of miR-495 in RCC. In addition, re-expression of SATB1 reversed the miR-495-induced inhibition of cell proliferation and migration. These data suggest that miR-495 functions as a tumor suppressor and may be a promising therapeutic target in RCC in the future.
ACCESSION #
111425517

 

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