Common Treatment of Polycystic Ovarian Syndrome and Major Depressive Disorder: Case Report and Review

Rasgon, N.L.; Carter, M.S.; Elman, S.; Bauer, M.; Love, M.; Korenman, S.G.
April 2002
Current Drug Targets - Immune, Endocrine & Metabolic Disorders;Apr2002, Vol. 2 Issue 1, p97
Academic Journal
We present the case of a young woman with treatment-resistant major depression, who presented to the Mood Disorders Clinic with a Hamilton Psychiatric Rating Scale for Depression (HAM-D-21) score of 28, after a year-long treatment with Effexor-XR. The patient also had untreated Polycystic Ovarian Syndrome (PCOS). The resolution of her depressive symptoms resulted from the treatment for PCOS with metformin and spironolactone. The patient remained euthymic 5 months after discontinuation of the antidepressant while continuing therapy for PCOS. We briefly overview of the pertinent literature of the pathophysiology of PCOS and affective disorders, highlighting an overlap in phenotypical presentations between these two disorders. Dysregulation of the hypothalamo-pituitary axis and various end organ systems are implicated in both PCOS and affective disorders. As such, several clinical and biochemical markers are common to both disorders, namely insulin resistance, obesity, and hyperandrogenism. In addition, these metabolic abnormalities are interrelated, causing women with PCOS or affective disorders to get caught in a �vicious cycle� of hormonal dysregulation. The case report presented here illustrates how treatment of symptoms such as insulin resistance and hyperandrogenism can lead to remission of major depressive disorder and PCOS. We suggest that through treatment of underlying metabolic defects, both the mood of the patient and the metabolic condition of PCOS can be assisted.


Related Articles

  • Effective Treatment for Depression: St. John's Wort.  // Annals of the American Psychotherapy Association;Winter2008, Vol. 11 Issue 4, p7 

    The article presents information on a study which examined the therapeutic use of St. John's wort for treating mental depression. Participants of the study were asked to rate the severity of their depression after taking various treatments, using the Hamilton Rating Scale for Depression. The...

  • Validity of the Hamilton Rating Scale for depression. Knesevich, J. W.; Biggs, J. T.; Clayton, P. J.; Ziegler, V. E. // British Journal of Psychiatry;Jul77, Vol. 131, p49 

    In 26 depressed patients, a high correlation (0-89) was found between the Hamilton score and a psychiatrist's global rating and between the change (0-68) in these ratings during treatment. The Hamilton scale was able to differentiate at the o-01 level four degrees of severity based on the global...

  • The Relationship Between Outdoor Recreation and Depression Among Individuals With Disabilities. Wilson, Justin F.; Christensen, Keith M. // Journal of Leisure Research;2012 Fourth Quarter, Vol. 44 Issue 4, p486 

    The purpose of this study is to identify the relationship between outdoor recreation participation and depressive symptoms among individuals with disabilities. The current paper compares three outdoor recreation predictors (dichotomized participation, participation index score, and participation...

  • Development of the EURO-D scale--a European, Union initiative to compare symptoms of depression in 14 European centres. Prince, M. J.; Reischies, F.; Beekman, A. T. F.; Fuhrer, R.; Jonker, C.; Kivela, S.-l.; Lawlor, B. A.; Lobo, A.; Magnusson, H.; Fichter, M.; van Oyen, H.; M. Roelands; I. Skoog; C. Turrina And J. R. M. Copeland; Beekman, A T; Roelands, M; Skoog, I; Turrina, C; Copeland, J R // British Journal of Psychiatry;Apr99, Vol. 174, p330 

    Background: In an 11-country European collaboration, 14 population-based surveys included 21,724 subjects aged > or = 65 years. Most participating centres used the Geriatric Mental State (GMS), but other measures were also used.Aims: To derive from these instruments a...

  • A comparison between the Hamilton Rating Scale and the Beck Inventory in the measurement of depression. Bailey, J.; Coppen, Alec; Coppen, A // British Journal of Psychiatry;May76, Vol. 128, p486 

    Correlations were made between ratings on the Hamilton Rating Scale for depression and the Inventory for measuring depression devised by Beck. Satisfactory and significant correlations were observed in only two-thirds of the patients, and often very divergent results were found in the remaining...

  • Depression symptoms in late life assessed using the EURO-D scale. Effect of age, gender and marital status in 14 European centres. Prince, M. J.; Beekman, A. T. F.; Deeg, D. J. H.; Fuhrer, R.; Kivela, S.-l.; Lawlor, B. A.; Lobo, A.; Magnusson, H.; Meller, I.; van Oyen, H.; Reischies, F.; Roelands, M.; Skoog, I.; Turrina, C.; Copeland, J. R. M.; Beekman, A T; Deeg, D J; Copeland, J R // British Journal of Psychiatry;Apr99, Vol. 174, p339 

    Background: Data from surveys involving 21,724 subjects aged > or = 65 years were analysed using a harmonised depression symptom scale, the EURO-D.Aims: To describe and compare the effects of age, gender and mental status on depressive symptoms across...

  • Detection of Depression in Acute Schizophrenia: Sensitivity and Specificity of 2 Standard Observer Rating Scales. Muller, Matthias J.; Muller, Kay-Maria; Fellgiebel, Andreas // Canadian Journal of Psychiatry;May2006, Vol. 51 Issue 6, p387 

    Objective: To compare the psychometric properties of the Calgary Depression Rating Scale (CDRS) and the Hamilton Depression Rating Scale (HDRS) for severity assessment of depression in acute schizophrenia. Method: During clinical routine treatment, we investigated 119 inpatients with acute...

  • Relationship Between Self-Report and Clinician-Rated Impairment in Depressed Outpatients. Kramer, Teresa L.; Owen, Richard R.; Wilson, Crystal; Thrush, Carol R. // Community Mental Health Journal;Aug2003, Vol. 39 Issue 4, p299 

    This study examined the potential of using the Global Assessment of Functioning (GAF) scale as a valid measure of patient-reported status and predictor of three-month outcomes for 59 patients seeking outpatient treatment for depression. A moderate relationship between the GAF and patient report...

  • An examination of the sensitivity of the six-item Hamilton Rating Scale for Depression in a sample of patients suffering from major depressive disorder. Hooper, Cynthia L.; Bakish, David // Journal of Psychiatry & Neuroscience;Mar2000, Vol. 25 Issue 2, p178 

    Examines sensitivity of the 6-item Hamilton Rating Scale for Depression (HRSD6) in patients suffering from major depressive disorder. Comparison of HRSD6 with the 17-item HRSD and Montgomery-Asberg Depression Rating Scale; Analysis of four antidepressant treatments; Need for a shorter and less...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics