Newson, Louise
September 2003
GP: General Practitioner;9/29/2003, p46
Observational studies have reported that the risk of ischaemic heart disease may be reduced by up to 40 per cent in women taking hormone replacement therapy. However, there are differences between studies thought to be related to selection bias, so interpretation is extremely difficult. The Heart and Estrogen/Progestin Replacement study was the first randomised controlled trial of 2,763 postmenopausal American women with ischaemic heart disease. Data showed combined oestrogen and progestogen had no effect on myocardial infarction or coronary death after treatment for 4.1 years. One study looked at angiographic progression of existing coronary artery disease and found no effect of either oestrogen or combined oestrogen and progestogen over a three-year period. INSET: Summary points.


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