Lack of association between HFE gene mutations and hepatocellular carcinoma in patients with cirrhosis

Boige, V.; Castéra, L.; de Roux, N.; Ganne-Carrié, N.; Ducot, B.; Pelletier, G.; Beaugrand, M.; Buffet, C.
August 2003
Gut;Aug2003, Vol. 52 Issue 8, p1178
Academic Journal
Background: Liver cirrhosis may lead to hepatocellular carcinoma (HCC), regardless of its cause. Genetic and/or environmental factors may modulate the risk of HCC. Mutations in the HFE gene are responsible for genetic haemochromatosis, a condition known to be associated with liver cirrhosis, HCC, or both. It has recently been suggested that the C282Y HFE gene mutation may be more frequent in patients with HCC that have developed in the non-cirrhotic liver than in the general population. Whether or not HFE gene mutations are associated with an increased risk of HCC in patients with cirrhosis is unknown. Aim: To assess the prevalence of HFE gene mutations in cirrhotic patients with and without HCC. Patients and methods: A total of 133 consecutive cirrhotic patients with HCC were prospectively studied for the presence of C282Y and H63D mutations. The control group consisted of 100 cirrhotic patients without HCC. We used restriction enzyme digestion of polymerase chain reaction amplified genomic DNA for determination of HFE genotypes. Iron loading was assessed on non-tumoral liver biopsy samples from 89 patients with HCC and 73 patients without HCC. Results: The prevalence of C282Y heterozygotes was similar in patients with and without HCC (5% v 4%, respectively; p=0.65) and did not differ from that expected in the general population. None of the HCC patients was found to be homozygous for C282Y or H63D, nor compound heterozygous. The prevalence of H63D heterozygotes was similar in patients with and without HCC (31% v 38%, respectively; p=0.25). No relation was detected between HFE genotypes and hepatic iron loading in patients with or without HCC. Conclusion: C282Y and H63D mutations do not appear to be associated with an increased risk of HCC in patients with cirrhosis.


Related Articles

  • Hepatocellular carcinoma surveillance: is risk stratification the way forward. Velazquez, R.F. // Gut;Jul2003, Vol. 52 Issue 7, p1068 

    Cites the article 'Prospective Analysis of Risk Factors for Hepatocellular Carcinoma in Patients With Liver Cirrhosis,' by R.F. Velazquez, M. Rodriguez et al, published in a 2003 issue of 'Hepatology.'

  • Risk for Hepatocellular Carcinoma in Patients With Alcoholic Cirrhosis. Abegunde, Ayokunle T.; Tillman, Hans L.; Choi, Steve S.; Jepsen, Peter; Ott, Peter; Vilstrup, Hendrik // Annals of Internal Medicine;11/6/2012, Vol. 157 Issue 9, p677 

    Two letters to the editor in response to the article "Risk for Hepatocellular Carcinoma in Patients With Alcoholic Cirrhosis: A Danish Nationwide Cohon Study," by Peter Jepsen, Peter Ott and Hendrik Vilstrup in the previous issue of the periodical and a response by the authors to the same are...

  • Risk of liver cancer among US male veterans with cirrhosis, 1969-1996. Persson, E C; Quraishi, S M; Welzel, T M; Carreon, J D; Gridley, G; Graubard, B I; McGlynn, K A // British Journal of Cancer;6/26/2012, Vol. 107 Issue 1, p195 

    Background:Liver cancer incidence rates in the United States have increased for several decades for reasons that are not entirely clear. Regardless of aetiology, cirrhosis is a strong risk factor for liver cancer. As mortality from cirrhosis has been declining in recent decades, it is possible...


    Hepatitis-B is an infectious disease of the liver and it is a serious health problem with more than two billion sufferers worldwide, around 350 million of which are chronic carriers of the disease. Associated risks include cirrhosis of the liver and liver cancer from which more than one million...

  • Spontaneous seroclearance of hepatitis B seromarkers and subsequent risk of hepatocellular carcinoma. Liu, Jessica; Hwai-I Yang; Mei-Hsuan Lee; Sheng-Nan Lu; Chin-Lan Jen; Batrla-Utermann, Richard; Li-Yu Wang; San-Lin You; Chuhsing K. Hsiao; Pei-Jer Chen; Chien-Jen Chen // Gut;Oct2014, Vol. 63 Issue 10, p1648 

    Background and aims The associations between long-term risk of hepatocellular carcinoma (HCC) and spontaneous seroclearance of HBV e antigen (HBeAg), HBV DNA and HBV surface antigen (HBsAg) have never been examined by a prospective study using serially measured seromarkers. This study aimed to...

  • Racial Differences in the Progression to Cirrhosis and Hepatocellular Carcinoma in HCV-Infected Veterans. El-Serag, Hashem B; Kramer, Jennifer; Duan, Zhigang; Kanwal, Fasiha // American Journal of Gastroenterology;Sep2014, Vol. 109 Issue 9, p1427 

    OBJECTIVES:The race of patients infected with hepatitis C virus (HCV) in the United States may be associated with the risk for cirrhosis and hepatocellular carcinoma (HCC). However, previous studies are too small to provide convincing data regarding the effect of race on cirrhosis and HCC risk...

  • An acute unusual presentation of hepatocellular carcinoma. Sharma, Zubin Dev; Gokhale, Vijayashree Shrirang; Chaudhari, Neha; Kakrani, Arjun Lal // Journal of Cancer Research & Therapeutics;Apr-Jun2014, Vol. 10 Issue 2, p401 

    Hepatocellular Carcinoma (HCC) is a growing cause of mortality world over. The common risk factors include cirrhosis, viral infections, aflatoxin amongst others. Alpha Fetoprotein (AFP) levels and Ultrasonography (USG) are the preferred surveillance tools in early diagnosis of HCC. Here we...

  • An overview on hepatitis C virus genotypes and its control. Nouroz, Faisal; Shaheen, Sidra; Mujtaba, Ghulam; Noreen, Shumaila // Egyptian Journal of Medical Human Genetics;2015, Vol. 16 Issue 4, p291 

    Hepatitis C virus (HCV) is a blood borne, circular and positive single stranded virus with high spread rates. With the passage of time the frequency of HCV is increasing in different parts of the world. HCV is a major cause, which may end in liver cirrhosis and hepatocellular carcinoma. HCV has...

  • The Frequency and Determinants of Liver Stiffness Measurement Failure: A Retrospective Study of “Real-Life” 38,464 Examinations. Ji, Dong; Shao, Qing; Han, Ping; Li, Fan; Li, Bing; Zang, Hong; Niu, Xiaoxia; Li, Zhongbin; Xin, Shaojie; Chen, Guofeng // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Objective: To investigate the frequency and determinants of liver stiffness measurement (LSM) failure by means of FibroScan in “real-life” Chinese patients. Methods: A total of 38,464 “real-life” Chinese patients in 302 military hospital of China through the whole year of...


Read the Article


Sign out of this library

Other Topics