Genetic influences in gastro-oesophageal reflux disease: a twin study
- Barrett's Esophagus: An Acquired Condition with Genetic Predisposition. Fahmy, Nabil; King, James F. // American Journal of Gastroenterology;Aug1993, Vol. 88 Issue 8, p1262
We describe four families with a strong familial expression of Barrett's/gastroesophageal reflux disease (GERD) complex spanning one to four generations with two to seven affected members per family. The purpose of this report is to highlight genetic trends in Barrett's esophagus, stress the...
- QT interval in twins. Carter, N; Snieder, H; Jeffery, S; Saumarez, R; Varma, C; Antoniades, L; Spector, T D // Journal of Human Hypertension;Jun2000, Vol. 14 Issue 6, p389
QT interval has been determined in 103 monozygotic (MZ) and 198 dizygotic (DZ) female twins. Mean values of corrected QT (QTc) were almost identical for both groups at 413 ms (MZ) and 412 ms (DZ). There was a significant age and environmental effect on QT interval. Heritability explained about...
- Risk Factors for Breast Cancer at Young Ages in Twins: An International Population-Based Study. Swerdlow, Anthony J.; De Stavola, Bianca L.; Floderus, Birgitta; Holm, Niels V.; Kaprio, Jaakko; Verkasalo, Pia K.; Mack, Thomas // JNCI: Journal of the National Cancer Institute;8/21/2002, Vol. 94 Issue 16, p1238
Identifies risk factors for breast cancer at young ages in twins. Confidence interval; Family history; Childhood growth before puberty; Distribution of body fat in young adulthood.
- ESOPHAGUS. // American Journal of Gastroenterology;Sep2007 Supplement 2, Vol. 102, pS119
The article presents abstracts on medical topics which include the use of photodynamic therapy in the treatment of Barrett's esophagus, the genetic factors of gastroesophageal reflux disease and a case on severe heartburn.
- Feasibility study for genetic testing and SNP analysis in infants. Neu, Madalynn; Ehringer, Marisa; Marcheggiani-Howard, Cassandra // Open Journal of Nursing;Feb2014, Vol. 4 Issue 2, p67
No abstract available.
- The Secretory Phospholipase A2 Gene is Required for Gastroesophageal Reflux-Related Changes in Murine Esophagus. Babu, Ashok; Mauchley, David; Xianzhong Meng; Banerjee, Anirban M.; Gamboni-Robertson, Fabia; Fullerton, David A.; Weyant, Michael J. // Journal of Gastrointestinal Surgery;Dec2009, Vol. 13 Issue 12, p2212
Background The initial response of esophageal mucosa to gastroduodenal reflux is inflammation and hyperplasia. Secretory phospholipase A2 (sPLA2) is a known mediator of gut inflammation, and its levels are increased in Barrett's esophagus. We hypothesized that the sPLA2 gene is required to...
- Amelia in Twin Pregnancy. Tanha, Fatemeh Davari; Mirzaaghaee, Farzaneh; Khezri, Marzie Karimi; Kaveh, Mahbod // Acta Medica Iranica;2009, Vol. 47 Issue 1, p79
Limb bud first appears during the third week of gestation with the upper limb buds appearing a few days before the lower limb buds. Complete absence of one or more limbs, called Amelia, occurs prior to the eighth week of gestation. We report a case of Amelia in a twin gestation.
- Importance of Family History and Genetics for the Prediction of Acute Appendicitis. Ergul, Emre // Internet Journal of Surgery;2007, Vol. 10 Issue 1, p2
Background: Although inflammatory disease of the vermiform appendix has been recognized as such for more than 100 years, its etiology remains a subject of controversy. The notion that appendicitis is familial, is not only important for understanding the etiology of the condition but might...
- Monochorionic Diamniotic Infants Without Twin-to-Twin Transfusion Syndrome. Cordero, Leandro; Franco, Albert; Joy, Saju D.; O'Shaughnessy, Richard W. // Journal of Perinatology;Dec2005, Vol. 25 Issue 12, p753
BACKGROUND:Monochorionic-diamniotic twins (MoDi) occur in 0.3% of all pregnancies. Twin-to-twin transfusion syndrome (TTS) that occurs in 20% of MoDi pregnancies is associated with high perinatal morbidity and mortality. MoDi twins without TTS are more frequent (80%) but have been scarcely...