TITLE

Mortality in Barrett's oesophagus: results from a population based study

AUTHOR(S)
Anderson, L.A.; Murray, L.J.; Murphy, S.J.; Fitzpatrick, D.A.; Johnston, B.T.; Watson, R.G.P.; McCarron, P.; Gavin, A.T.
PUB. DATE
August 2003
SOURCE
Gut;Aug2003, Vol. 52 Issue 8, p1081
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Patients with Barrett's oesophagus have an increased risk of oesophageal adenocarcinoma but this cancer only accounts for a small proportion of deaths in these patients. Other causes of death are reportedly raised in this group. We examined cause specific mortality among individuals in a population based Barrett's oesophagus register. Methods: We constructed a register of all patients diagnosed with columnar mucosa (including specialised intestinal metaplasia) of the oesophagus within Northern Ireland between 1993 and 1999. Deaths occurring within this cohort until 31 December 2000 were identified and mortality rates were compared with the general population. Results: Overall mortality was not raised in Barrett's patients. During 7413 person years of follow up in 2373 patients there were 253 deaths (standardised mortality ratio (SMR) 96 (95% confidence interval (CI) 84-107)). Mortality from oesophageal cancer was raised in patients with specialised intestinal metaplasia (SMR 774 (95% CI 317-1231)) but only 4.7% of patients died from this cancer. Mortality from stroke (SMR 65 (95% CI 37-93)) was significantly lower than the general population while mortality from non-cancerous digestive system diseases was significantly higher (SMR 211 (95% CI 111311)). Mortality rates from all other causes were similar to those of the general population. Conclusions: This study demonstrates that the overall mortality rate in patients with Barrett's oesophagus is closely similar to that of the general population. Oesophageal cancer mortality was raised but is an uncommon cause of death in these patients who also appear to have a reduced risk of death from stroke.
ACCESSION #
11097182

 

Related Articles

  • Short Segment Barrett's Esophagus: Ignorance May Be Bliss. Richter, Joel E. // American Journal of Gastroenterology;Jun2006, Vol. 101 Issue 6, p1183 

    Data suggest the incidence of Barrett's esophagus is increasing, but the vast majority are of the short segment (SS) variety. Whether SSBE has an increased cancer risk is poorly defined, whereas overdiagnosis is common and it is associated with increased insurance costs and perception of cancer...

  • Barrett's oesophagus: epidemiology comes up with a surprise. Heading, R.C. // Gut;Aug2003, Vol. 52 Issue 8, p1079 

    Focuses on the epidemiology of Barrett's esophagus. Increase of the risk of esophageal carcinoma; Mortality associated with Barrett's esophagus; Reduction of approximately 50% in the risk of death from stroke in Barrett's esophagus.

  • Prevalence of Esophageal Cancer Risk Factors among Turkmen and Non-Turkmen Ethnic Groups in a High Incidence Area in Iran. Marjani, Haji Amin; Biramijamal, Firouzeh; Hossein-Nezhad, Arash; Islami, Farhad; Pourshmas, Akram; Semnani, Shahrir // Archives of Iranian Medicine (AIM);Mar2010, Vol. 13 Issue 2, p111 

    Background: Golestan Province in north-eastern Iran has one of the highest incidence rates for esophageal squamous cell carcinoma (ESCC) worldwide. Earlier studies have reported higher incidence rates in the areas of Golestan which are mainly inhabited by individuals of the Turkmen ethnic group....

  • Barrett's esophagus.  // Mayo Clinic Health Letter;Jul2003, Vol. 21 Issue 7, p7 

    Provides information on Barrett's esophagus, a disease associated with an increased risk of cancer of the esophagus.

  • Gastroesophageal Reflux Disease: Diagnosis and Management. Scott, Mark; GELHOT, AIMEE R. // American Family Physician;3/1/1999, Vol. 59 Issue 5, p1161 

    Part I. Discusses the etiology and treatment of gastroesophageal reflux disease. Overview of the disease; Pathophysiology; Clinical presentation; Response to omeprazole.

  • The Incidence of Adenocarcinoma and Dysplasia in Barrett's Esophagus. O'Connor, J. Barry; Falk, Gary W.; Richter, Joel E. // American Journal of Gastroenterology;Aug1999, Vol. 94 Issue 8, p2037 

    OBJECTIVE: The reported incidence of adenocarcinoma in Barren's esophagus is variable. The aim of this study was to determine the incidence of dysplasia and adenocarcinoma in a population of patients with Barrett's esophagus followed prospectively and to compare these findings with other series....

  • Esophagus Cancer Incidence among Females in Golestan Province, Iran (2004). Marjani, Abdoljalal; Kabir, Mohammad Javad; Semnani, Shahriyar; Sedaghat, Seyyed Mehdi; Moghaddami, Abbas // Journal of Medical Sciences;2008, Vol. 8 Issue 1, p90 

    The main aim of this study was to find and describe province-specific estimates of incidence in females by age groups for esophagus cancer. The data used in this study were collected in a cancer registry that was conducted by Health Deputy of Golestan province for a period of 1 year (2004). The...

  • Carcinoma of the Proximal Esophagus, A Complication of Long-standing Achalasia. Seliger, Gustav; Lee, Thomas; Schwartz, Solomon // American Journal of Gastroenterology;Jan1972, Vol. 57 Issue 1, p20 

    Describes the cases of carcinoma of the esophagus developing in patients with achalasia. Background on the patients; Difficulty of diagnosing carcinoma in the esophagus; Results of Heller myotomy performed on the patients.

  • Achalasia Complicated by Multiple Intramucosal Carcinomas: Report of a Case. Naruo Kawasaki; Yutaka Suzuki; Nobuo Omura; Kazuto Tsuboi; Akira Matsumoto; Hideyuki Kashiwagi; Katsuhiko Yanaga // Surgery Today;Oct2007, Vol. 37 Issue 10, p897 

    Abstract  A 56-year-old woman underwent a laparoscopic Heller–Dor operation for esophageal achalasia in June 2002. As dysphagia became exacerbated and the oral intake became extremely poor, an esophagectomy was thus considered to be indicated. In September 2005, a transhiatal...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics