TITLE

Liver tolerance mediated by antigen presenting cells: fact or fiction?

AUTHOR(S)
Lau, A.H.; de Creus, A.; Lu, L.; Thomson, A.W.
PUB. DATE
August 2003
SOURCE
Gut;Aug2003, Vol. 52 Issue 8, p1075
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Discusses the debate on possible on possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction. Factors influencing the facilitation of tolerance; Contribution of APC to the extensive apoptosis of systemically activated T cells within the liver; Evolution of the telogenic properties of the liver; Role of the hepatic microenvironment rich in interleukin-10 in the promotion of tolerance.
ACCESSION #
11097180

 

Related Articles

  • Antigen presentation: Presenting a newly charged antigen. Honey, Karen // Nature Reviews Immunology;Jul2004, Vol. 4 Issue 7, p489 

    Discusses research being done on the capability of certain polysaccharides processed with antigen-presenting cells to associate with major histocompatibility complex (MHC) class II molecules and induce cluster of differentiation T-cell responses. Reference to a study by B. A. Cobb, Q. Wang, A....

  • Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. Dillon, Stephanie; Agrawal, Sudhanshu; Banerjee, Kaustuv; Letterio, John; Denning, Timothy L.; Oswald-Richter, Kyra; Kasprowicz, Deborah J.; Kellar, Kathryn; Pare, Jeff; Van Dyke, Thomas; Ziegler, Steven; Unutmaz, Derya; Pulendran, Bali // Journal of Clinical Investigation;Apr2006, Vol. 116 Issue 4, p916 

    Emerging evidence suggests critical roles for APCs in suppressing immune responses. Here, we show that zymosan, a stimulus for TLR2 and dectin-1, regulates cytokine secretion in DCs and macrophages to induce immunological tolerance. First, zymosan induces DCs to secrete abundant IL-10 but little...

  • Composite Tissue Allotransplantation Immunology. Seok Chan Eun // Archives of Plastic Surgery;Mar2013, Vol. 40 Issue 2, p141 

    The article reviews key terminology, drug combinations, mechanisms of immunosuppression, the risks associated with composite tissue allotransplantation (CTA) and immune tolerance protocols. It discusses the immune-mediated rejection associated with CTA. The role of antigen presenting cells in...

  • Is immunologic tolerance of self modulated through antigen presentation by parenchymal epithelium? Neilson, Eric G. // Kidney International;Nov1993, Vol. 44 Issue 5, p927 

    Examines the role of antigen presentation by parenchymal epithelium in the modulation of immunological tolerance of self. Significance of the interaction between T cell receptors and the major histocompatibility complex-restriction determinant to the maintenance of peripheral tolerance; Role of...

  • Augmentation of the migratory ability of DC-based vaccine into regional lymph nodes by efficient CCR7 gene transduction. Okada, N; Mori, N; Koretomo, R; Okada, Y; Nakayama, T; Yoshie, O; Mizuguchi, H; Hayakawa, T; Nakagawa, S; Mayumi, T; Fujita, T; Yamamoto, A // Gene Therapy;Jan2005, Vol. 12 Issue 2, p129 

    Although dendritic cell (DC)-based immunotherapy is considered a promising approach for cancer treatment, a large quantity of DC vaccine is required for effective sensitization/activation of immune cells because of the poor migratory ability of administered DCs into regional lymphoid tissue. In...

  • Manifestations of immune tolerance in the human female reproductive tract. Clark, Gary F.; Schust, Danny J.; Stein-Streilein, Joan; Meinhardt, Andreas // Frontiers in Immunology;Feb2013, Vol. 4, Special section p1 

    Like other mucosal surfaces (e.g., the gastrointestinal tract, the respiratory tract), the human female reproductive tract acts as an initial barrier to foreign antigens. In this role, the epithelial surface and subepithelial immune cells must balance protection against pathogenic insults...

  • Round Cells of the Epidermis: Clues from Studies on Neoplastic Lymphocytes of Cutaneous T Cell Lymphoma. Edelson, Richard L. // Journal of Investigative Dermatology;Jul80, Vol. 75 Issue 1, p95 

    Neoplastic cells of cutaneous T cell lymphoma (CTCL) appear to be of monoclonal origin and frequently are nonspecific helpers of normal B cell differentiation. A natural progression from epidermotropic (mycosis fungoides and Sézary syndrome) to nonepidermotropic, more widely disseminated T...

  • The Dendritic Cell-T Cell Synapse as a Determinant of Autoimmune Pathogenesis. Iruretagoyena, Mirentxu I.; Wiesendanger, Margrit; Kalergis, Alexis M. // Current Pharmaceutical Design;Jan2006, Vol. 12 Issue 2, p131 

    Autoimmune diseases occur when the immune response is targeted to self-antigens, leading to destruction or altered function of specific cells and tissues. Although the aetiology of these diseases has not yet been fully elucidated, it is believed that genetically determined susceptibility and...

  • Regulation of Dendritic Cell Function with Immunomodulatory Drugs. Mohty, M.; Gaugler, B.; Mami, N. Ben; Olive, D. // Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy A;Apr2005, Vol. 4 Issue 2, p169 

    Dendritic cells (DC) represent a sentinel-like system with the capacity to capture and process antigens, to migrate into secondary lymphoid organs, and to activate naive T lymphocytes. DCs are considered as important elements in the induction of specific immune responses. The potency of DCs for...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics