Correlation between thromboembolic score and anteroposterior diameter of left atrium and left ventricle ejection fraction in patients with atrial fibrillation

Lazic, Snezana; Markovic, Sanja; Sipic, Maja; Lazic, Bratislav
September 2015
Cardiologia Croatica;Sep/Oct2015, Vol. 10 Issue 9/10, p28
Academic Journal
OBJECTIVES : It is considered that atrial fibrillation (AF) is present among 0.4% of adult population. CHA2 DS2 -VASc score is used for stratification of thromboembolic risk. Systolic heart failure has significant thrombogenic potential in atrial fibrillation. Data from the literature on causal relationship between enlarged left atrium and thromboembolic risk in patients with AF are controversial.PATIENTS AND METHODS : The study analyzed 90 patients with atrial fibrillation. Exclusion criterion was AF in sepsis, acute myocarditis and pericarditis, in acute myocardial infarction, and postoperative AF. Methods used were standard 12-lead ECG, transthoracic echocardiogram and laboratory tests. The first group included 12 (13.3%) patients with valvular AF, while the second group included 78 (86.7%) patients with non-valvular AF. RESULTS : Anteroposterior diameter of the left atrium was 55.6±11.5 mm vs. 46.3±6.2 mm in the second group; p<0.001. Ejection fraction (EF, %) was 37.1±10.1% in the first group vs. 43.0±11.6% in the second group; p=0.102. CHA2 DS2 -VASc score was 4.0 (1.0-6.0) in the first group vs. 3.0 (0.0-7.0) in the second group; p=0.132. The correlation between CHA2 DS2 -VASc score and anteroposterior diameter of the left atrium among all patients (n=90) was not statistically significant (r=1.0; p=0.346). Significant negative correlation was found between CHA2 DS2 -VASc score and EF among all patients (r=-0.420; p<0.001). CONCLUSIONS : In our study, the anteroposterior diameter of left atrium was not a determining factor of thromboembolic risk. However, with increase of CHA2 DS2 -VASc score, there was a reduction of EF which favors AF and increase in thromboembolic risk.


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