Evaluation of Interleukin-10 Levels in Patients Diagnosed with Chronic Hepati

Özgüler, M.; Akbulut, H. H.; Akbulut, A.
March 2015
West Indian Medical Journal;Mar2015, Vol. 64 Issue 2, p71
Academic Journal
Objective: One of the most important factors playing a role in chronic hepatitis B pathogenesis is cytokine release and one of the cytokines with anti-inflammatory characteristic is interleukin-10 (IL-10). The aim of the present study is to examine IL-10 levels in patients with chronic hepatitis B. Subjects and Methods: Sixty-three patients with chronic hepatitis B disease who had not received any antiviral treatment were included in the study. Serum IL-10 level was investigated by enzyme-linked immunosorbent assay (ELISA) method. In the control group, 25 healthy individuals with mean age similar to the patient population were included. Control and patient groups were compared and data were statistically analysed. Results: Interleukin-10 levels of 25 patients with hepatitis B virus (HBV) DNA levels between 2000 and 20 000 IU/mL were compared with those of 25 subjects in the control group, and the level in the chronic hepatitis B group was statistically significantly higher (p < 0.05). Interleukin-10 levels of 38 patients with HBV DNA > 20 000 IU/mL were statistically significantly higher than those in the control group. When chronic hepatitis B patients were compared among themselves, IL-10 levels increased as HBV DNA levels increased. Also, when IL-10 levels of hepatitis B 'e' antigen (HBeAg) positive patients were compared with those of HBeAg negative patients, the difference was not statistically significant. Conclusion: It is believed that decreasing IL-10 levels by various methods would have significant contributions in disease progression and treatment. Moreover, IL-10 level may be an important marker in HBeAg seroconversion and evaluation of treatment response.


Related Articles

  • Missing effects of zinc in a porcine model of recurrent endotoxemia. Krones, Carsten J.; Klosterhalfen, Bernd; Anurov, Michael; Stumpf, Michael; Klinge, Uwe; Oettinger, Alexander P.; Schumpelick, Volker // BMC Surgery;2005, Vol. 5, p22 

    Background: Chronic human sepsis often is characterised by the compensatory antiinflammatory response syndrome (CARS). During CARS, anti-inflammatory cytokines depress the inflammatory response leading to secondary and opportunistic infections. Proved in vitro as well as in vivo, zinc's...

  • Effect of meloxicam on gingival crevicular fluid IL-1beta and IL1 receptor antagonist levels in subjects with chronic periodontitis, and its effects on clinical parameters. Toker, Hulya; Marakoglu, Ismail; Poyraz, Omer // Clinical Oral Investigations;Dec2006, Vol. 10 Issue 4, p305 

    The aim of the present study was to determine the effects of meloxicam after initial periodontal treatment on interleukin-1beta (IL-1β) and IL-1 receptor antagonist (IL-1ra) in gingival crevicular fluid (GCF) and clinical parameters in the chronic periodontitis patients. Data were obtained...

  • Gene polymorphism and protein of human proand anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients. Wings TY Loo; Chang-bin Fan; Lan-jun Bai; Yuan Yue; Yi-ding Dou; Min Wang; Hao Liang; Cheung, Mary N. B.; Chow, Louis W. C.; Jin-le Li; Ye Tian; Liu Qing // Journal of Translational Medicine;2012 Supplement, Vol. 10 Issue Suppl 1, p1 

    Background: Periodontal disease is thought to arise from the interaction of various factors, including the susceptibility of the host, the presence of pathogenic organisms, and the absence of beneficial species. The genetic factors may play a significant role in the risk of periodontal diseases....

  • Evaluation of the KEMRI Hep-cell II test kit for detection of hepatitis B surface antigens in Tanzania. KILALE, ANDREW M.; RANGE, NYAGOSYA S.; NGOWI, PROSPER H.; KAHWA, AMOS M.; MFINANGA, SAYOKI G. // Tanzania Journal of Health Research;Jul2012, Vol. 14 Issue 3, p1 

    Hepatitis B surface antigen (HBsAg) is one of the most important serological markers used to diagnose acute and chronic hepatitis B infection. The objective of the current evaluation was to assess the operational characteristics of the Kenya Medical Research Institute (KEMRI) Hep-cell II against...

  • Angiogenesis blockade as a new therapeutic approach to experimental colitis. Danese, Silvio; Sans, Miquel; Spencer, David M.; Beck, Ivy; Doñate, Fernando; Plunkett, Marian L.; De La Matte, Carol; Redline, Raymond; Shaw, David E.; Levine, Alan D.; Mozar, Andrew P.; Fiocchi, Claudio // Gut;Jun2007, Vol. 56 Issue 6, p855 

    Background: Neoangiogenesis is a critical component of chronic inflammatory disorders. Inhibition of angiogenesis is an effective treatment in animal models of inflammation, but has not been tested in experimental colitis. Aim: To investigate the effect of ATN-161, an anti-angiogenic compound,...

  • Variation of Anti-inflammatory Cytokines in Relationship with Menopause. MĂLUŢAN, Andrei Mihai; COSTIN, Nicolae; CIORTEA, Razvan; MIHU, Dan // Applied Medical Informatics;Jun2013, Vol. 32 Issue 2, p30 

    Aim. The aim of this study was to assess serum levels of the key anti-inflammatory cytokines in women of reproductive age and in pre and postmenopausal women. Material and Method. 175 women were enrolled and were divided into 5 groups (1 - Fertile women; 2 - Pre- and perimenopausal women; 3 -...

  • Roles of elevated intravitreal IL-1β and IL-10 levels in proliferative diabetic retinopathy. Chunjie Mao; Hua Yan // Indian Journal of Ophthalmology;Jun2014, Vol. 62 Issue 6, p699 

    To determine the roles of interleukin (IL)-1β and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR). Materials and Methods: Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1β and IL-10 concentration...

  • Decreased Interleukin-10 Responses in Children with Severe Mycoplasma pneumoniae Pneumonia. Ding, Shenggang; Wang, Xiaowu; Chen, Wei; Fang, Yuan; Liu, Boyu; Liu, Yan; Fei, Guanghe; Wang, Linding // PLoS ONE;1/11/2016, Vol. 11 Issue 1, p1 

    Several cytokines may play roles in the immunological pathogenesis of mycoplasmal pneumonia caused by Mycoplasma pneumoniae. In this study, we investigated serum cytokine profiles in children with mycoplasmal pneumonia. The serum levels of interleukin (IL)-8, IL-10, and IL-18 were examined using...

  • CHANGES OF CYTOKINE PROFILE IN PATIENTS BLOOD WITH PREMATURE RUPTURE OF AMNIOTIC MEMBRANES AND THEIR PATHOGENIC SIGNIFICANCE. Mikhaylov, A. V.; Dyatlova, L. I.; Chesnokova, N. P.; Ponu-kalina, E. V.; Glukhova, T. N. // Saratov Journal of Medical Scientific Research / Saratovskii Nau;Apr-Jun2013, Vol. 9 Issue 2, p225 

    Purpose: Pathogenetic study of new diagnostic and prognostic criteria for evaluation of pregnancy in terms of the cytokine profile of blood. Materials and methods: The analysis of anti-inflammatory and pro-inflammatory cytokines in the blood of 50 pregnant women with preterm rupture of membranes...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics