TITLE

Meta-analysis of vagus nerve stimulation treatment for epilepsy: correlation between device setting parameters and acute response

AUTHOR(S)
Ghani, S.; Vilensky, J.; Turner, B.; Tubbs, R.; Loukas, M.
PUB. DATE
December 2015
SOURCE
Child's Nervous System;Dec2015, Vol. 31 Issue 12, p2291
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Vagus nerve stimulation (VNS) is an adjunctive neurophysiological treatment for those patients who have pharmacoresistant or surgically resistant partial onset epilepsy. Objective: The aim of this study is to determine the effects of high and low stimulation paradigms on a responder rate of ≥50 and ≥75 % reduction in seizure frequency and associated adverse effects in adults and children. Method: A literature search was performed using Medline, PubMed, EMBASE, and Cochrane library for studies using vagus nerve stimulation published from January 1980 until July 2014 for medically or surgically resistant partial onset seizures, in children and adults. No restrictions on languages were imposed. Data collection and analysis: Four authors reviewed and selected studies for inclusion and exclusion. The search identified five randomized control trials that fit with our inclusion criteria. The following outcomes were evaluated: 50 % or greater reduction in total seizure frequency, 75 % or greater reduction in total seizure frequency, and adverse effects. Results: Four randomized controlled trials were analyzed in this meta-analysis. Results indicate high stimulation is more effective in adult patients who experienced ≥50 and ≥75 % reduction in seizure frequency with a significant difference within both high and low stimulation groups. In children, there was no significant difference between the two groups and patients with ≥50 % reduction in seizures. Adverse effects such as hoarseness and dyspnea were more common in the high stimulation group where the remaining side effects were not statistically different among both groups. Conclusion: High stimulation is more effective than low stimulation in producing a greater reduction in seizure frequency in patients with medically and surgically resistant epilepsy.
ACCESSION #
110861279

 

Related Articles

  • A New Era in Epilepsy Treatment. March, Keith // Medical Update;2003, Vol. 28 Issue 10, p7 

    Deals with the use of vagus nerve stimulation therapy in patients with epilepsy. Use of electrical impulses to the spinal cord on the treatment of several diseases; Statistics on epileptics in the U.S.; Information on the implantation of the stimulation device.

  • Vagus nerve stimulation in children with intractable epilepsy: indications, complications and outcome. Kabir, S.; Rajaraman, C.; Rittey, C.; Zaki, H.; Kemeny, A.; McMullan, J. // Child's Nervous System;Sep2009, Vol. 25 Issue 9, p1097 

    To analyze the indication, complications and outcome of vagus nerve stimulation in intractable childhood epilepsy. We retrospectively reviewed the data of 69 children who had insertion of vagal nerve stimulator (VNS) between June 1995 and August 2006 for medically intractable epilepsy. Outcome...

  • Vagus Nerve Stimulation for Refractory Status Epilepticus? Greb, Erik // Neurology Reviews;Mar2013, Vol. 21 Issue 3, p1 

    The article focuses on part results obtained from a 10 year study conducted on 550 patients with epilepsy. The results showed that nerve simulation of vagus nerve may help epilepsy patients to gain better seizure control. Dean Christine, director at the Epilepsy Institute of North Carolina at...

  • Electrical Stimulation for the Treatment of Epilepsy Boon, Paul; Raedt, Robrecht; de Herdt, Veerle; Wyckhuys, Tine; Vonck, Kristl // Neurotherapeutics;Apr2009, Vol. 6 Issue 2, p218 

    Summary: Despite the advent of new pharmacological treatments and the high success rate of many surgical treatments for epilepsy, a substantial number of patients either do not become seizure-free or they experience major adverse events (or both). Neurostimulation-based treatments have gained...

  • Vagus Nerve Stimulation in the Treatment of Refractory Epilepsy Milby, Andrew H.; Halpern, Casey H.; Baltuch, Gordon H. // Neurotherapeutics;Apr2009, Vol. 6 Issue 2, p228 

    Summary: Many patients with epilepsy suffer from persistent seizures despite maximal anti-epileptic drug therapy. Chronic, intermittent vagus nerve stimulation has been proven to be an effective option for many patients suffering from refractory seizures who are not candidates for surgical...

  • Nerve stimulator useful in treating epilepsy.  // Mayo Clinic Health Letter;Aug1999, Vol. 17 Issue 8, p4 

    Reports on the use of a vagus nerve stimulator approved by the United States Food & Drug Administration to help reduce partial epileptic seizures. Site of implantation; Programming of the device; Effectiveness of the device.

  • BIONICS BEATS BRAIN DISORDERS. Fumento, Michael // Saturday Evening Post;Jul/Aug2006, Vol. 278 Issue 4, p80 

    This article provides information on implantable vagus nerve stimulation (VNS), which is used for the treatment of epilepsy. Small wires from the device, currently made only by Cyberonics of Houston, Texas, are tunneled under the skin to the left vagus nerve in the neck. In pacemaker fashion,...

  • Predictors of Response to Vagus Nerve Stimulation in Childhood-Onset Medically Refractory Epilepsy. Arya, Ravindra; Greiner, Hansel M.; Lewis, Amanda; Horn, Paul S.; Mangano, Francesco T.; Gonsalves, Cornelia; Holland, Katherine D. // Journal of Child Neurology;Dec2014, Vol. 29 Issue 12, p1652 

    This study explored predictors of response to vagus nerve stimulation in childhood-onset epilepsy. This retrospective chart review included all patients with new vagus nerve stimulator insertion between January 1, 2006, and December 31, 2011. Primary outcome was change in seizure frequency...

  • New Developments With Vagus Nerve Stimulation Therapy. Howland, Robert H. // Journal of Psychosocial Nursing & Mental Health Services;Mar2014, Vol. 52 Issue 3, p11 

    The vagus nerve is a major component of the autonomic nervous system, has an important role in the regulation of metabolic homeostasis, and plays a key role in the neuro-endocrine-immune axis. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve. Left cervical...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics