TITLE

Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases

AUTHOR(S)
Yaman, Yöntem; Gözmen, Salih; Özkaya, Ahmet Kağan; Oymak, Yeşim; Apa, Hursit; Vergin, Canan; Devrim, Ilker
PUB. DATE
October 2015
SOURCE
Journal of Infection in Developing Countries;Oct2015, Vol. 9 Issue 10, p1172
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy. It continues to be an important health problem worldwide. Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, hepatosplenomegaly, cytopenias, high serum levels of ferritin and triglycerides, low serum fibrinogen levels, and hemophagocytosis in bone marrow, lymph nodes, spleen, or liver. Hemophagocytic lymphohistiocytosis associated with brucellosis is a very rare condition in the pediatric age group. Here, three pediatric cases of secondary HLH associated with brucellosis are reported. Hemophagocytic lymphohistiocytosis should be considered in patients with brucellosis having cytopenias. Hemophagocytosis in brucellosis seems to be cured with appropriate antibiotics and intravenous immunoglobulin.
ACCESSION #
110781155

 

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