Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer

Demirbaş, Tuna; Cimilli, Tan; Bayramoğlu, Sibel; Güner, Nurten Turan; Hocaoğlu, Elif; İnci, Ercan
June 2014
Balkan Medical Journal;Jun2014, Vol. 31 Issue 2, p154
Academic Journal
Background: Cervical cancer is the second most common female malignancy worldwide. Although its incidence has decreased in developed countries due to screening with Papanicolaou test, it is still the leading cause of cancer-related female death in developing countries. Aims: The aim of this study was to determine whether the apparent diffusion coefficient (ADC) measurements calculated from diffusion-weighted imaging (DWI) images had any contribution in differentiation of normal cervical tissue from malignant lesions preoperatively, and whether there was a correlation between the mean ADC values and tumor type, grade, or stage in malignant lesions. Study Design: Case-control study. Methods: Mean ADC values in 25 patients who had cervical cancer proved histopathologically, and 20 patients with otherwise normal uterus were compared. Also in the study group, mean ADC values were compared between histopathologic subtypes, tumor grades, and stages. Results: In the study group the mean ADC values (0.96±0.15x10-3 mm²/s) were statistically lower than that of the control group (1.67±0.17x10-3 mm²/s) (p<0.05). According to histopathologic subtypes there was no significant difference between mean ADC values of squamous cell cancer and adenocarcinoma (0.95x10-3 mm²/s and 0.91x10-3 mm²/s, respectively) (p>0.05). There was also no significant difference between the mean ADC values of the tumor grades (p>0.05). The mean ADC values in early stage cervical cancer (0.86±0.05x10-3 mm²/s) were significantly lower than the mean ADC values in late stage disease (0.98±0.06x10-3 mm²/s) (p<0.05). Conclusion: ADC value measurements may provide useful information in diagnosis of cervical cancer as well as in preoperative assessment of the tumor stage.


Related Articles

  • MR imaging of carcinoma cervix. Mahajan, Mangal; Kuber, Rajesh; Chaudhari, K. R.; Chaudhari, Prashant; Ghadage, Pravin; Naik, Rushikesh // Indian Journal of Radiology & Imaging;Aug2013, Vol. 23 Issue 3, p247 

    Cervical cancer is a common gynecological malignancy and a frequent cause of death. Patient outcome depends on tumor stage, size, nodal status, and histological grade. Correct tumor staging is important to decide the treatment strategy. Magnetic Resonance Imaging is accepted as a preferred...

  • CERVICAL CARCINOMA. Amos, Holly; Spencer, Sherril // Synergy: Imaging & Therapy Practice;Nov2014, p23 

    No abstract available.

  • Value of apparent diffusion coefficient (ADC) in evaluating response of carcinoma of the cervix treated with chemoradiotherapy. le Roux, A.; Gebremariam, F.; Harmse, W. // South African Journal of Radiology;Mar2013, Vol. 17 Issue 1, p11 

    Objective. To determine whether the apparent diffusion coefficient (ADC) value obtained by diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a reliable detector of response of carcinoma of the cervix treated with chemoradiotherapy, compared with conventional T2-weighted MRI....

  • Ectopic cervical thymus as a rare cause of pediatric neck mass: the role of ultrasound and MRI in the diagnosis. Case report. Ozel, Alper; Ozdemir Akdur, Pınar; Celebi, Irfan; Karasu, Rabia; Yılmaz, Banu; Basak, Muzaffer // Medical Ultrasonography;Jun2015, Vol. 17 Issue 2, p248 

    Ectopic cervical thymus (ECT) is an uncommon cause for cervical mass in the pediatric age group. Ultrasound and magnetic resonance imaging findings of the mass (location along the thymic descent pathway along the thymopharyngeal tract and the identical echostructure and signal intensities to the...

  • 18F-FDG PET in stage IB/IIB cervical adenocarcinoma/adenosquamous carcinoma. Hung-Hsueh Chou; Hsiu-Ping Chang; Chyong-Huey Lai; Koon-Kwan Ng; Swei Hsueh; Tzu-I Wu; Ming-Yu Chen; Tzu-Chen Yen; Ji-Hong Hong; Ting-Chang Chang // European Journal of Nuclear Medicine & Molecular Imaging;Apr2010, Vol. 37 Issue 4, p728 

    The diagnostic and prognostic value of 18F-FDG PET in cervical adenocarcinoma/adenosquamous carcinoma (AC/ASC) is unclear. The aim of this study was to assess the value of PET in the management of cervical AC/ASC. Patients with resectable FIGO stage IB/IIB cervical AC/ASC receiving a...

  • Frequency distribution of HPV18 based on the detection of E6 oncoprotein gene in cervix cancer samples. Mostafavizadeh SM; Niakan M; Ahmadi A; Aghabozorgi S; Lak R; Piroozmand A // Feyz Journal of Kashan University of Medical Sciences;Jul2013, Vol. 17 Issue 3, p287 

    Background: Persistent infection with high-risk human papillomavirus (HPV) is one of the most important risk factors for developing cervix cancer. Since cell culture and serological methods have no diagnostic value for the detection of this virus and its variants, the importance of molecular...

  • The Observatory. Cancer.  // MLO: Medical Laboratory Observer;Nov2016, Vol. 48 Issue 11, p11 

    The article explains the safety of cervical cancer diagnosis for women aged at least 40 years and not infected with human papilloma virus, based on a study published in the "British Medical Journal."

  • Adolescent TMJ Tomography and Magnetic Resonance Imaging: A Comparative Analysis. Kameichuk, Lorne; Nebbe, Brian; Baker, Charles; Major, Paul // Journal of Orofacial Pain; 

    The predictive value of radiographic tomoraphy was assessed using magnetic resonance imaging as a definitive test of TMJ soft-tissue status in a predominantly asymptomatic adolescent sample. Eighty-two TMJs in 41 subjects (mean age = 12.5 years, range = 10 to 17 years) were independently...

  • Accuracy of Conventional MRI in ALS. Gupta, Aparna; Nguyen, Thanh Binh; Chakraborty, Santanu; Bourque, Pierre R. // Canadian Journal of Neurological Sciences;Jan2014, Vol. 41 Issue 1, p53 

    The article presents a case-control study which examines the accuracy of conventional magnetic resonance imaging (MRI) in detecting amyotrophic lateral sclerosis (ALS). The study analyzes clinical and MRI data from 64 patients with a definite retrospective diagnosis of ALS. It suggests that...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics