TITLE

By the company they keep: interaction networks define the binding ability of transcription factors

AUTHOR(S)
Cirillo, Davide; Botta-Orfila, Teresa; Tartaglia, Gian Gaetano
PUB. DATE
October 2015
SOURCE
Nucleic Acids Research;10/30/2015, Vol. 43 Issue 19, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Access to genome-wide data provides the opportunity to address questions concerning the ability of transcription factors (TFs) to assemble in distinct macromolecular complexes. Here, we introduce the PAnDA (Protein And DNA Associations) approach to characterize DNA associations with human TFs using expression profiles, protein-protein interactions and recognition motifs. Our method predicts TF binding events with >0.80 accuracy revealing cellspecific regulatory patterns that can be exploited for future investigations. Even when the precise DNAbinding motifs of a specific TF are not available, the information derived from protein-protein networks is sufficient to perform high-confidence predictions (area under the ROC curve of 0.89). PAnDA is freely available at http://service.tartaglialab.com/ new submission/panda.
ACCESSION #
110668176

 

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