TITLE

High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting

AUTHOR(S)
Nilsson, Maria; Hägglöf, Christina; Hammarsten, Peter; Thysell, Elin; Stattin, Pär; Egevad, Lars; Granfors, Torvald; Jernberg, Emma; Wikstrom, Pernilla; Halin Bergström, Sofia; Bergh, Anders
PUB. DATE
October 2015
SOURCE
PLoS ONE;10/26/2015, Vol. 10 Issue 10, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Lysyl oxidase (LOX) has been shown to both promote and suppress tumor progression, but its role in prostate cancer is largely unknown. LOX immunoreactivity was scored in prostate tumor epithelium, tumor stroma and in the tumor-adjacent non-malignant prostate epithelium and stroma. LOX scores in tumor and non-malignant prostate tissues were then examined for possible associations with clinical characteristics and survival in a historical cohort of men that were diagnosed with prostate cancer at transurethral resection and followed by watchful waiting. Men with a low LOX score in the non-malignant prostate epithelium had significantly longer cancer specific survival than men with a high score. Furthermore, LOX score in non-malignant prostate epithelium remained prognostic in a multivariable analysis including Gleason score. LOX score in prostate tumor epithelium positively correlated to Gleason score and metastases but was not associated with cancer survival. LOX score in tumor and non-malignant prostate stroma appeared unrelated to these tumor characteristics. In radical prostatectomy specimens, LOX immune-staining corresponded to LOX in-situ hybridization and LOX mRNA levels were found to be similar between tumor and adjacent non-malignant areas, but significantly increased in bone metastases samples. LOX levels both in tumors and in the surrounding tumor-bearing organ are apparently related to prostate cancer aggressiveness.
ACCESSION #
110540257

 

Related Articles

  • Placement of retrievable self-expandable metallic stents with barbs into patients with obstructive prostate cancer. Song, Ho-Young; Kim, Choung; Jeong, In; Yoo, Dalsan; Kim, Jin; Nam, Deok; Bae, Jae-Ik; Park, Jung-Hoon // European Radiology;Mar2013, Vol. 23 Issue 3, p780 

    Objectives: To evaluate the technical feasibility and clinical effectiveness of retrievable self-expandable metallic stents with barbs in patients with obstructive prostate cancer. Methods: Retrievable self-expandable metallic stents with eight barbs each were inserted into eight consecutive...

  • Intravesical explosion: a rare complication of transurethral resection of prostate. Oğuz, Gonca; Subaşı, Deniz; Kaya, Menşure; Güven, Oğuz; Ünver, Süheyla // Journal of Anesthesia;2013, Vol. 27 Issue 1, p145 

    A letter to the editor is presented about a case of intravesical explosion during transurethral resection of prostate cancer in an 82-year-old patient.

  • Active Surveillance Cuts Prostate Cancer Costs in Half. Goth, Greg // Healthdatamanagement.com;5/6/2014, p1 

    The article reports on a research from McGill University Health Center which found that active surveillance of men with low-risk prostate cancer is more cost-effective than immediate treatment.

  • 5-ARIs Cut Risk of PCa Progression.  // Renal & Urology News;Jan/Feb2016, Vol. 15 Issue 1, p15 

    The article presents a study as of early 2016, which showed that males on active surveillance (AS) long-term who take 5-alpha-reductase inhibitors (5-ARI) have a slower rate of prostate cancer progression and are more likely to continue AS than those who do not take the 5-ARIs.

  • Triple cancer: chronic lymphocytic leukemia with bladder and prostate carcinoma. GAJENDRA, Smeeta; SHARMA, Rashi; SAHOO, Manas Kumar // Malaysian Journal of Pathology;Aug2015, Vol. 37 Issue 2, p159 

    B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a common lymphoproliferative disorder with an increased risk of developing subsequent neoplasms of epithelial and mesenchymal origin. The decreased immunity and B-cell dysfunction in CLL probably accounts for this...

  • Gross hematuria in patients with prostate cancer: etiology and management. Gofrit, Ofer N.; Katz, Ran; Shapiro, Amos; Yutkin, Vladimir; Pizov, Galina; Zorn, Kevin C.; Duvdevani, Mordechai; Landau, Ezekiel H.; Pode, Dov // ISRN Surgery;2013, p1 

    The objective of the study is to assess the etiology and prognosis of gross hematuria (GH) in patients with carcinoma of the prostate (CAP). From 1991 to 2011, 81 men (mean age 74.3 years, SD 6.5) with CAP were hospitalized with GH. Primary treatment of CAP was radical surgery in 13 patients...

  • Bipolar button-electrode plasma vaporization of the prostate: An effective option for patients with post-brachytherapy retention. YIWEI LIN; BEN LIU; LIPING XIE // Experimental & Therapeutic Medicine;Oct2015, Vol. 10 Issue 4, p1309 

    Urinary retention is a common urinary complication following brachytherapy for prostate cancer. When conservative therapy has failed, surgical intervention, such as transurethral resection of the prostate (TURP), is performed. In the present case, it was found that conventional bipolar TURP was...

  • 18F-flouro-2-deoxyglucose positron emission tomography/computed tomography imaging of solitary prostatic and pulmonary tuberculosis mimicking metastatic prostate cancer. Kadihasanoglu, Mustafa; Yildiz, Tekin; Atahan, Safak; Ausmus, Andrew; Atahan, Ozcan // Journal of Cancer Research & Therapeutics;Jul-Sep2015, Vol. 11 Issue 3, Special section p663 

    Genitourinary tuberculosis (TB) is a common type of extrathoracic TB and can be found in isolation or associated with pulmonary TB. It contributes to 10-14% of extrapulmonary TB. Prostate TB is rare and usually found incidentally following transurethral resection of the prostate for treatment of...

  • Transurethral resection of a large bladder hemangioma of mixed histological composition: a case report. Martov, Alexey G; Pominalnaya, Viktoriya M; Kurkov, Alexandr V; Baykov, Nikolay A; Gomzikova, Ekaterina A; Fayzullin, Alexey L; Balykov, Ilya S; Ergakov, Dmitry V // Research & Reports in Urology;Jun2019, Vol. 11, p175 

    Hemangioma is a rare benign vascular tumor of the bladder, which occurs mainly in children. It has no specific clinical symptoms but can result in severe and fatal complications as well as relapse. In the current clinical observation, a 35-year-old patient had a large solid tumor of the bladder...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics