Correlation of CD146 expression and clinicopathological characteristics in esophageal squamous cell carcinoma

August 2014
Oncology Letters;2014, Vol. 8 Issue 2, p859
Academic Journal
CD146, a cell adhesion molecule, is found in normal and tumor tissues. The level of its expression has been found to directly correlate with tumor progression and metastatic potential. The objective of this study was to investigate the expression of CD146 in esophageal squamous cell carcinoma (ESCC) and its correlation with clinicopathological parameters. Tumor specimens were collected from 63 patients with ESCC who underwent complete resection. We analyzed the CD146 expression levels in ESCC by immunohistochemistry. The expression of CD146 was detected and it was observed to correlate with clinicopathological parameters. Sixty-three cases of normal squamous mucosa were included for comparison. CD146 expression was identified in 46.0% (29/63) of the ESCC samples, and no positive (weak to moderate or moderate to strong) expression was found in the normal squamous epithelium samples (χ²=27.248; P<0.0001). CD146 expression was associated with lymph node metastasis (χ²=5.117; P=0.024) and advanced clinical stage (χ²=4.661; P=0.031). CD146 expression was one of the significant predictors of survival (hazard ratio, 2.838; 95% confidence interval 1.102-7.305). The overexpression of the CD146 gene was one of the important phenotypes and characteristics in ESCC carcinomatous change. We found that CD146 expression was associated with lymph node metastasis and advanced clinical stage, and was an indicator of poor prognosis in ESCC patients. CD146 may prove to be an important tumor marker for the individualized treatment for ESCC.


Related Articles

  • Motility-related protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma. Uchida, S; Shimada, Y; Watanabe, G; Li, Z Gang; Hong, T; Miyake, M; Imamura, M // British Journal of Cancer;3/1/99, Vol. 79 Issue 7/8, p1168 

    Although the mechanisms of action of the transmembrane superfamilies, motility-related protein-1 (MRP-1/CD9) and KAI1/CD82, are not well known, they are reported to suppress the metastasis of several kinds of cancers. The suppression of cell motility by MRP-1/CD9 may cause suppression of the...

  • E-Cadherin Promoter Hypermethylation in Preneoplastic and Neoplastic Skin Lesions. Melissa C. Chiles; Lingbao Ai; Chunlai Zuo; Chun-yang Fan; Smoller, Bruce R. // Modern Pathology;Oct2003, Vol. 16 Issue 10, p1014 

    E-cadherin is a calcium-dependent, intercellular adhesion molecule that is specifically expressed in epithelial tissues and plays an important role in maintaining epithelial stability. E-cadherin is widely regarded as a prognostic marker in many types of human cancers. The inactivation of the...

  • Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma. Mukherjee, Sumana; Roth, Mark J.; Dawsey, Sanford M.; Yan, Wusheng; Rodriguez-Canales, Jaime; Erickson, Heidi S.; Nan Hu; Goldstein, Alisa M.; Taylor, Philip R.; Richardson, Annely M.; Tangrea, Michael A.; Chuaqui, Rodrigo F.; Emmert-Buck, Michael R. // Journal of Translational Medicine;2010, Vol. 8, p91 

    Background: Esophageal squamous cell carcinomas (ESCC) are usually asymptomatic and go undetected until they are incurable. Cytological screening is one strategy to detect ESCC at an early stage and has shown promise in previous studies, although improvement in sensitivity and specificity are...

  • The Prognostic Impact of Lymph Node Involvement in Large Scale Operable Node-Positive Esophageal Squamous Cell Carcinoma Patients: A 10-Year Experience. Xu, Xiao-Ling; Zheng, Wei-Hui; Zhu, Shuang-Mei; Zhao, An; Mao, Wei-Min // PLoS ONE;7/15/2015, Vol. 10 Issue 7, p1 

    Background: Lymph node (LN)-related factors including the number of LN regions involved, the LN ratio (LNR), and the number of metastatic LNs are strong prognostic indicators for esophageal squamous cell carcinoma (ESCC) patients. Accurately staging LN involvement may improve the stratification...

  • Isolated Nasal Tip Metastasis from Esophageal Squamous Cell Carcinoma: Case Report and Literature Review. Ledderose, Georg J.; Englhard, Anna S. // Case Reports in Otolaryngology;6/14/2015, Vol. 2015, p1 

    Objectives. Cutaneous metastases can be the first sign of a malignant disease and have an unfavorable prognostic significance. The external nose is rarely affected. The uncommon clinical presentation of these cutaneous metastases may lead to the wrong diagnosis and treatment. Methods. We present...

  • Multiple and metachronous esophageal intramural metastases from a gastric adenocarcinoma. Ikeda, Osamu; Toh, Yasushi; Aoki, Yoshiro; Harimoto, Norifumi; Taomoto, Jyunya; Masuda, Takaaki; Ohga, Takefumi; Adachi, Eisuke; Sakaguchi, Yoshihisa; Okamura, Takeshi; Hirahashi, Minako; Nishiyama, Kenichi; Baba, Hideo // Gastric Cancer;Jun2008, Vol. 11 Issue 2, p119 

    Esophageal squamous cell carcinoma is often accompanied by intramural metastases, and it has been reported to carry a poor prognosis. Intramural metastasis from gastric cancer to the esophageal wall, however, has rarely been reported. We herein report a rare case of a 46-year-old man with an...

  • Squamous Cell Carcinoma of Proximal Esophagus with Simultaneous Metastases to Thyroid and Sternum: A Case Report and Review of the Literature. Moulick, Avijit; Guha, Pradipta; Das, Anirban; Das, Anjan Kumar // Tanaffos;2012, Vol. 11 Issue 1, p67 

    Clinically significant metastatic spread to the thyroid is considered uncommon in spite of the fact that thyroid is a highly vascularized organ. Though it is not a very uncommon finding at autopsies, it is rare to be found in clinical situations, especially in an individual without a prior...

  • MicroRNA-98 and microRNA-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma. Huang, Sheng-Dong; Yuan, Yang; Zhuang, Chon-Wen; Li, Bai-Ling; Gong, De-Jun; Wang, Shu-Gang; Zeng, Zhi-Yong; Cheng, He-Zhong // Molecular Cancer;2012, Vol. 11 Issue 1, p51 

    Background: The enhancer of zeste homolog 2 (EZH2) was found to be overexpressed and associated with tumor metastasis in esophageal squamous cell carcinoma (ESCC). On the other hand, it was reported that miR-26a, miR-98, miR-101, miR-124, miR-138 and miR-214 could inhibit the expression of EZH2...

  • Case of childhood laryngeal papillomatosis with metastatic carcinoma esophagus in adulthood. Shetty, Nishitha; Kumar, Prabhash; Joshi, Amit; Sayed, Suhail I.; Sharma, Shilpi; Noronha, Vanita; Deshmukh, Anuja; Chaukar, Devendra; Kane, S.; Gopal; D'cruz, Anil K. // Indian Journal of Medical & Paediatric Oncology;Jan-Mar2013, Vol. 34 Issue 1, p34 

    A young male patient was diagnosed to have laryngeal papillomas at the age of 3 years for which he underwent permanent tracheostomy and also multiple surgical and laser excision procedures. Then, later in life, the patient had progressive breathlessness and dysphagia. On examination, he had...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics