Significant association between the Axin2 rs2240308 single nucleotide polymorphism and the incidence of prostate cancer

August 2014
Oncology Letters;2014, Vol. 8 Issue 2, p789
Academic Journal
The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single nucleotide polymorphism (SNP) rs2240308 [guanine (G)/adenine (A)] and the incidence of prostate cancer. In total, 103 patients with prostate cancer and 100 cancer-free control males were included in this case-control study, and were genotyped using the genomic DNA extracted from peripheral blood samples. The results revealed a higher incidence of prostate cancer in the subjects with the homozygous GG genotype and a reduced cancer incidence in the patients with the GA genotype of the rs2240308 SNP (G/A) in the Axin2 gene. The adjusted odds ratio for carriers with the GA genotype was 0.377 (95% CI, 0.206-0.688; P=0.001) and that for the AA genotype was 0.830 (95% CI, 0.309-2.232; P=0.712) compared with the GG genotype. Therefore, the GA genotype was found to exhibit a protective effect that decreased the risk of prostate cancer. To the best of our knowledge, this is the first study to demonstrate the significant association between this SNP (rs2240308, G/A) and the risk of prostate cancer. This association indicates the possibility that the variations in the Axin2 gene in this position may play a significant role in promoting the development of cancer in the prostate. We believe that the Axin2 SNP (rs2240308) could be a useful biomarker for the predisposition and early diagnosis of the disease.


Related Articles

  • Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. Kim, Wan-tae; Kim, Hyunjoon; Katanaev, Vladimir L; Joon Lee, Seung; Ishitani, Tohru; Cha, Boksik; Han, Jin-Kwan; Jho, Eek-hoon // EMBO Journal;8/15/2012, Vol. 31 Issue 16, p3384 

    DP1, a dimerization partner protein of the transcription factor E2F, is known to inhibit Wnt/?-catenin signalling along with E2F, although the function of DP1 itself was not well characterized. Here, we present a novel dual regulatory mechanism of Wnt/?-catenin signalling by DP1 independent from...

  • Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta. Martino-Echarri, Estefania; Brocardo, Mariana G.; Mills, Kate M.; Henderson, Beric R. // PLoS ONE;3/1/2016, Vol. 11 Issue 3, p1 

    Activation of the wnt signaling pathway is a major cause of colon cancer development. Tankyrase inhibitors (TNKSi) have recently been developed to block the wnt pathway by increasing axin levels to promote degradation of the wnt-regulator β-catenin. TNKSi bind to the PARP (poly(ADP)ribose...

  • SMURF and NEDD4: sharp shooters monitor the gate keepers and ion traffic controllers of lead astray cell. Farooqi, Ammad; Waseem, Makhdoom; Riaz, Asma; Bhatti, Shahzad; Farooqi, Ammad Ahmad; Waseem, Makhdoom Saad; Riaz, Asma M // Journal of Membrane Biology;Nov2011, Vol. 244 Issue 1, p1 

    It is becoming increasingly apparent that a complex bar code underlies the quantitative aspects of extracellular signal regulation. Cell type-specific and context-dependent transcriptional programs are triggered by sophisticated nanomachinery consisting of HECT enzymes which monitor signal...

  • WNT SIGNALING IN PROSTATE DEVELOPMENT AND CARCINOGENESIS. Kharaishvili, Gvantsa; Simkova, Dana; Makharoblidze, Eka; Trtkova, Katerina; Kolar, Zdenek; Bouchal, Jan // Biomedical Papers of the Medical Faculty of Palacky University i;Mar2011, Vol. 155 Issue 1, p11 

    Background. The Wnt signaling pathway is crucial for cell fate decisions, stem cell renewal, regulation of cell proliferation and differentiation. Deregulated Wnt signaling is also implicated in a number of hereditary and degenerative diseases and cancer. Methods and results. This review...

  • Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling. Zhao, Zhiyan; Herman, James G.; Brock, Malcolm V.; Sheng, Jindong; Zhang, Meiying; Liu, Baoguo; Guo, Mingzhou // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1 

    Thyroid cancer is the most common endocrine malignant disease and the incidence is increasing. DACT2 was found frequently methylated in human lung cancer and hepatocellular carcinoma. To explore the epigenetic change and the role of DACT2 in thyroid cancer, 7 thyroid cancer cell lines, 10 cases...

  • Behavioral stress accelerates prostate cancer development in mice. Hassan, Sazzad; Karpova, Yelena; Baiz, Daniele; Yancey, Dana; Pullikuth, Ashok; Flores, Anabel; Register, Thomas; Cline, J. Mark; D'Agostino Jr., Ralph; Danial, Nika; Robert Datta, Sandeep; Kulik, George // Journal of Clinical Investigation;Feb2013, Vol. 123 Issue 2, p874 

    Prostate cancer patients have increased levels of stress and anxiety. Conversely, men who take beta blockers, which interfere with signaling from the stress hormones adrenaline and noradrenaline, have a lower incidence of prostate cancer; however, the mechanisms underlying stress-prostate cancer...

  • Replication and Fine Mapping for Association of the C2orf43, FOXP4, GPRC6A and RFX6 Genes with Prostate Cancer in the Chinese Population. Qing-Zhi Long; Yue-Feng Du; Xiao-Ying Ding; Xiang Li; Wen-Bin Song; Yong Yang; Peng Zhang; Jian-Ping Zhou; Xiao-Gang Liu // PLoS ONE;May2012, Vol. 7 Issue 5, p1 

    Background: Prostate cancer represents the leading cause of male death across the world. A recent genome-wide association study (GWAS) identified five novel susceptibility loci for prostate cancer in the Japanese population. This study is to replicate and fine map the potential association of...

  • Pathway Analysis of a Genome-Wide Association Study of Ileal Crohn's Disease. Lee, Young Ho; Song, Gwan Gyu // DNA & Cell Biology;Oct2012, Vol. 31 Issue 10, p1549 

    The aim of this study was to identify the candidate single-nucleotide polymorphisms (SNPs) and candidate mechanisms of Crohn's disease (CD) and to generate a SNP to gene to pathway hypothesis using a pathway-based approach, ICSNPathway (Identify candidate Causal SNPs and Pathways) of genome-wide...

  • Identification of SNPs in Cellular Retinol Binding Protein 1 and Cellular Retinol Binding Protein 3 Genes and Their Associations with Laying Performance Traits in Erlang Mountainous Chicken. Yan Wang; Li-Hua Xiao; Xiao-Ling Zhao; Yi-Ping Liu; Qing Zhu // Asian-Australasian Journal of Animal Sciences;Aug2014, Vol. 27 Issue 8, p1075 

    CRBP1 (cellular retinol binding protein 1) and CRBP3 (cellular retinol binding protein 3), are important components of the retinoid signaling pathway and take part in vitamin A absorption, transport and metabolism. Based on the role of vitamin A in chicken laying performance, we investigated the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics