Effect of interleukin 21 and its receptor on CD8+ T cells in the pathogenesis of diffuse large B-cell lymphoma

July 2014
Oncology Letters;2014, Vol. 8 Issue 1, p421
Academic Journal
Interleukin 21 (IL-21) and its receptor, IL-21R, play a key role in innate and adaptive immunity. In the present study, the effect of IL-21 and IL-21R on the pathogenesis of diffuse large B-cell lymphoma (DLBCL) was investigated. The serum levels of IL-21 were detected by enzyme-linked immunosorbent assay, and the expression of IL-21R on CD8+ T cells was examined through flow cytometry. The data showed that the serum level of IL-21 was significantly decreased in the patients with DLBCL compared with the healthy controls (P<0.001), whereas the expression of IL-21R was clearly elevated on the CD8+ T cells in the patients with DLBCL. Further analyses revealed that the downregulation of the IL-21 serum level was correlated with an increased tumor stage of DLBCL, while the expression of IL-21R on the CD8+ T cells was positively correlated with the tumor stage. Also, the serum level of IL-21 and the proportion of IL-21R on the CD8+ T cells were negatively correlated in the patients. Notably, it was identified that the proportion of IL-21R on the CD8+ T cells, but not the serum level of IL-21, was significantly upregulated in the patients with bone-marrow involvement and B symptoms. These results indicate that IL-21 and IL-21R may be involved in the pathogenesis of DLBCL, in which IL-21R may reflect the progression of the disease more accurately than the serum level of IL-21.


Related Articles

  • Attenuation of Peripheral Regulatory T-Cell Suppression of Skin-Homing CD8+ T Cells in Atopic Dermatitis. Bao-Xiang Zhang; Jun-Cheng Lyu; Hai-Bo Liu; Dian-Qin Feng; Dian-Cai Zhang; Xing-Jie Bi; Zhi-Wu Duan; Gang Ding // Yonsei Medical Journal;Jan2015, Vol. 56 Issue 1, p196 

    Purpose: Cutaneous lymphocyte-associated antigen (CLA)-expressing CD8+T cells have been known to play an important role in the pathogenesis of atopic dermatitis (AD). However, the mechanisms underlying the loss of self-tolerance remain unclear. Regulatory T cells (Tregs) play a key role in the...

  • Serum IL-21 levels associated with chronic hepatitis B and hepatitis B-related liver failure. HONG-MEI CHEN; HONG-LI LIU; YU-CONG YANG; XIAO-LI CHENG; YUE-FEI WANG; FAN-FAN XING; YING-REN ZHAO // Experimental & Therapeutic Medicine;2014, Vol. 7 Issue 4, p1013 

    The aim of the present study was to investigate the role of interleukin (IL)-21 in chronic hepatitis B virus (HBV) infection. IL-21 stimulates T and B cell responses and plays a role in the control of chronic viral infections. Serum IL-21 levels were measured by enzyme immunoassay in 109...

  • Assessment of the immunogenicity and protective efficiency of a novel dual-promoter DNA vaccine, harboring SAG1 and GRA7 genes, from RH strain of Toxoplasma gondii in BALB/c mice. Mavi, Sara Ayazian; Modarressi, Mohammad Hossein; Mohebali, Mehdi; Shojaee, Saeedeh; Zeraati, Hojjat; Teimouri, Aref; Keshavarz, Hossein // Infection & Drug Resistance;Aug2019, Vol. 12, p2519 

    Background: Toxoplasmosis, a protozoan parasitic disease caused by Toxoplasma gondii, has been a serious human and veterinary medicine problem with global distribution. In the current study, we assessed immunogenicity and protective efficiency of a novel dual-promoter DNA vaccine, harboring SAG1...

  • Upregulation of Tim-3 on CD4+ T cells is associated with Th1/Th2 imbalance in patients with allergic asthma. Fei Tang; Fukun Wang; Liyun An; Xianling Wang // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 3, p3809 

    T cell Ig and mucin domain-containing molecule-3 (Tim-3) is a negative regulator preferentially expressed on Th1 cells. Allergic asthma is a clinical syndrome well characterized by Th1/Th2 imbalance. To investigate the role of Tim-3 in the pathogenesis of asthma and its relationship with Th1/Th2...

  • Multifaceted Adult T-Cell Leukemia/Lymphoma in India: A Case Series. Khader, Anza; Shaan, Mohamed; Balakrishnan, Sunitha; Ambooken, Betsy; Muhammed, Kunnummel; Rajan, Uma // Indian Journal of Dermatology;Jan/Feb2015, Vol. 60 Issue 1, p1 

    Background: Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). India is considered as a nonendemic region for HTLV-1. Recent upsurge of cases have been noted in southern parts of India. Aims and objectives: The objective was to describe skin...

  • In vitro synthesis of primary specific anti-breast cancer antibodies by normal human peripheral blood mononuclear cells. Thakur, Archana; Norkina, Oxana; Lum, Lawrence // Cancer Immunology, Immunotherapy;Dec2011, Vol. 60 Issue 12, p1707 

    In this study, we developed a unique in vitro model to mimic the endogenous tumor microenvironment to understand the effect of immunotherapy with activated T-cells (ATC) armed with anti-CD3 × anti-Her2 bispecific antibody (aATC) on antibody response by naive immune cells. This model...

  • Elevated Serum IL-21 Levels in Hantavirus-Infected Patients Correlate with the Severity of the Disease. Chen, Hongmei; Liu, Hongli; Wang, Yuefei; Yang, Yucong; Zhao, Yingren // Inflammation;Aug2014, Vol. 37 Issue 4, p1078 

    Hemorrhagic fever with renal syndrome (HFRS) is an acute viral infection caused by Hantavirus (HTV). Capillary leakage is one of the hallmarks of HTV infection. The mechanisms underlying the pathogenesis of HFRS are not completely understood. However, it has been suggested that immune...

  • Predicting autoimmunity after alemtuzumab treatment of multiple sclerosis. Azzopardi, Laura; Thompson, Sara A. J.; Harding, Katherine E.; Cossburn, Mark; Robertson, Neil; Compston, Alastair; Coles, Alasdair J.; Jones, Joanne L. // Journal of Neurology, Neurosurgery & Psychiatry;Jul2014, Vol. 85 Issue 7, p795 

    Objective We have previously shown that autoimmunity following alemtuzumab treatment of multiple sclerosis can be predicted by high baseline serum interleukin IL-21 (IL-21), as measured using a now 'redundant' enzyme linked immunosorbent assay (ELISA). Here we ask whether currently available...

  • Interleukin-16 as a Marker of Sézary Syndrome Onset and Stage. Richmond, Jillian; Tuzova, Marina; Parks, Ashley; Adams, Natalie; Martin, Elizabeth; Tawa, Marianne; Morrison, Lynne; Chaney, Keri; Kupper, Thomas; Curiel-Lewandrowski, Clara; Cruikshank, William // Journal of Clinical Immunology;Jan2011, Vol. 31 Issue 1, p39 

    Introduction: Sézary syndrome is one of the most common forms of cutaneous T cell lymphoma (CTCL). It is characterized by skin infiltration of malignant T cells. We examined interleukin-16, a potent T cell chemoattractant and cell-cycle regulator, as a prospective marker of disease onset and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics