Extracts of centipede Scolopendra subspinipes mutilans induce cell cycle arrest and apoptosis in A375 human melanoma cells

July 2014
Oncology Letters;2014, Vol. 8 Issue 1, p414
Academic Journal
Extracts from the centipede Scolopendra genus, have been used in traditional medicine for the treatment of various diseases and have been found to exhibit anticancer activity in tumor cells. To investigate the potential and associated antitumor mechanism of alcohol extracts of the centipede Scolopendra subspinipes mutilans (AECS), cell viability, cell cycle and cell apoptosis were studied and the results revealed that AECS inhibits A375 cell proliferation in a dose- and time-dependent manner. In addition, AECS was found to arrest the cell cycle of A375 cells at the S phase, which was accompanied by a marked increase in the protein levels of cyclin E and a decrease in the protein levels of cyclin D1. In a cell culture system, AECS markedly induced the apoptosis of A375 cells, which was closely associated with the effects on the Bcl-2 family, whereby decreased Bcl-2 and increased Bak, Bax and Bad expression levels were observed. The underlying mechanism of AECS inhibiting A375 cell proliferation was associated with the induction of cell cycle arrest and apoptosis, indicating that AECS may present as a potential therapeutic agent for administration in human melanoma cancer intervention.


Related Articles

  • Therapeutic Efficacy by Targeting Correction of Notch1-Induced Aberrants in Uveal Tumors. Xiaolin Huang; Li Wang; He Zhang; Haibo Wang; Xiaoping Zhao; Guanxiang Qian; Jifan Hu; Shengfang Ge; Xianqun Fan; Schrijver, Iris // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    There is a need for more effective treatments for uveal melanoma. The recombinant oncolytic adenovirus H101 replicates specifically in p53-depleted tumor cells, and has been approved for use by the Chinese State Food and Drug Administration. However, this treatment is associated with...

  • Radionuclides and trace elements in centipede species Scolopendra cingulata from Serbia. Antović, I.; Stojanović, D.; Svrkota, N.; Žižić, R.; Antić, D.; Antović, N. // Journal of Radioanalytical & Nuclear Chemistry;Nov2014, Vol. 302 Issue 2, p791 

    The adults of centipede Scolopendra cingulata from Serbia have been analyzed for Bi, Cs, Ac, K, Pb and Pb activity. The top 5 cm of soil from the same locations (Novi Pazar, Izbice and Pčinja) is also measured-to estimate upper limit of the soil- S. cingulata radionuclide transfer factors...

  • Research advances on TCM anti-tumor effects and the molecular mechanisms. Xiaochun Qiu; Jack Jia // Journal of Cancer Research & Therapeutics;Aug2014 Special Issue, Vol. 10 Issue S5, pC8 

    With unceasingly deep researches on tumor cytology and molecular biology in recent years, it has been recognized that tumor is not only the outcome of occurrence and progress of cell proliferative disorders and abnormal differentiation, but also closely related to abnormality of apoptosis. Since...

  • Antimicrobial peptides in the centipede Scolopendra subspinipes mutilans. Yoo, Won; Lee, Joon; Shin, Younhee; Shim, Jae-Young; Jung, Myunghee; Kang, Byeong-Chul; Oh, Jaedon; Seong, Jiyeon; Lee, Hak; Kong, Hong; Song, Ki-Duk; Yun, Eun-Young; Kim, In-Woo; Kwon, Young-Nam; Lee, Dong; Hwang, Ui-Wook; Park, Junhyung; Hwang, Jae // Functional & Integrative Genomics;Jun2014, Vol. 14 Issue 2, p275 

    The centipede Scolopendra subspinipes mutilans is an environmentally beneficial and medically important arthropod species. Although this species is increasingly applied as a reliable source of new antimicrobial peptides, the transcriptome of this species is a prerequisite for more rational...

  • The Centipede Genus Scolopendra in Mainland Southeast Asia: Molecular Phylogenetics, Geometric Morphometrics and External Morphology as Tools for Species Delimitation. Siriwut, Warut; Edgecombe, Gregory D.; Sutcharit, Chirasak; Panha, Somsak // PLoS ONE;8/13/2015, Vol. 10 Issue 8, p1 

    Seven Scolopendra species from the Southeast Asian mainland delimited based on standard external morphological characters represent monophyletic groups in phylogenetic trees inferred from concatenated sequences of three gene fragments (cytochrome c oxidase subunit 1, 16S rRNA and 28S rRNA) using...

  • Correction: The Centipede Genus Scolopendra in Mainland Southeast Asia: Molecular Phylogenetics, Geometric Morphometrics and External Morphology as Tools for Species Delimitation. null, null // PLoS ONE;9/22/2015, Vol. 10 Issue 9, p1 

    No abstract available.

  • Editorial. Lens, Marko // Current Topics in Medicinal Chemistry;Jan2012, Vol. 12 Issue 1, p2 

    An introduction is presented in which the editor discusses various reports within the issue on topics including the potential value of carcinoembryonic antigen-related cell adhesion molecule as a melanoma biomarker and therapeutic target, the importance of angiogenesis in melanoma, and...

  • Primary cells suppress oncogene-dependent apoptosis. Duelli, Dominik M.; Lazebnik, Yuri A. // Nature Cell Biology;Nov2000, Vol. 2 Issue 11, p859 

    Oncogenes that promote cell-cycle progression also sensitize cells to agents that induce apoptosis. Sensitization is thought to be caused by the induction of proapoptotic factors. Alternatively, sensitization may require the inactivation of inhibitors that ordinarily provide protection against...

  • Human parvovirus B19-induced cell cycle arrest and apoptosis. Morita, Eiji; Sugamura, Kazuo // Springer Seminars in Immunopathology;Jun2002, Vol. 24 Issue 2, p187 

    Examines human parvovirus B19-induced cell cycle arrest and apoptosis. Reclassification of the human parvovirus B19 into a genus called Erythrovirus of the Parvoviridae; Evidence that parvovirus B19 induces cytotoxicity of erythroid precursor cells with apoptotic features; Molecular...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics