Early and late urodynamic assessment of the orthotopic N-shaped neobladder

August 2013
Oncology Letters;2013, Vol. 6 Issue 4, p1053
Academic Journal
The present study aimed to report the urodynamic data from 46 male patients who underwent an orthotopic N-shaped neobladder replacement following a radical cystectomy during a 12-month period and to provide urodynamic evidence for the improvement of this technique. A total of 46 consecutive male patients underwent a radical cystectomy and orthotopic N-shaped neobladder substitution due to muscle-invasive bladder cancer. Uroflowmetry, cystometry and urethral pressure profilometry were analyzed at 3-12 months following the surgery. The mean pressure of the neobladders was <15 cm H²O at volumes of <400 ml and 22.4 cm H²O at 100% capacity at 6 months. The mean pressure of the contractions was <40 cm H²O at 6 months. The mean filling pressure following the surgery at 3 months was higher compared with that at 6 months. No difference was observed at the other time-points. When comparing the 9- and 12-month urodynamic characteristics, no significant changes were observed in the cystometric capacity. The mean post-void residual (PVR) urine volume was 58 ml. A mean voiding peak of 16.2 ml/sec was obtained using the Valsalva maneuver. The daytime continence rate was 90% at 12 months while the night-time continence rate was 60%.


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