Post-operative urothelial recurrence in patients with upper urinary tract urothelial carcinoma managed by radical nephroureterectomy with an ipsilateral bladder cuff: Minimal prognostic impact in comparison with non-urothelial recurrence and other clinical indicators

August 2013
Oncology Letters;2013, Vol. 6 Issue 4, p1015
Academic Journal
Upper urinary tract urothelial carcinoma (UTUC) is a rare disease, and novel prognostic factors for patients who have undergone a radical nephroureterectomy (RNU) for UTUC have been studied intensely. To the best of our knowledge, the prognostic value of urothelial recurrence in patients with UTUC has not been previously described in studies. The present study compared the prognostic value of urothelial and non-urothelial recurrence in patients with UTUC of the kidney and ureter managed by surgery. The inclusion criteria consisted of a diagnosis of non-metastatic UTUC (any T stage, N0-1 and M0) and receipt of an RNU with an ipsilateral bladder cuff as the primary treatment. Of the 153 patients that were screened for the study, comprehensive clinical and pathological data was available for 103 patients, who were consequently included in the analysis. Overall survival (OS) and cancer-specific survival (CSS) times were estimated. A multivariate analysis was performed using the Cox regression model. The median follow-up period was 29 months (interquartile range, 14-63 months). The patient population was comprised of 71 males (68.9%o) and 32 females (31.1%). A total of 32 patients (31.1%) showed non-urothelial recurrence, while 38 patients (36.9%) exhibited urothelial recurrence and 33 patients (32.0%) exhibited no recurrence. When comparing the risk parameters between the non-urothelial recurrence categories, the factors of pathological grade, microvascular invasion, lymphatic invasion and pT classification showed significant differences. However, there were no significant differences between the urothelial recurrence categories. No significant difference was observed between the OS and CSS times within the urothelial recurrence categories (P=0.3955 and P=0.05891, respectively), but significant differences were identified in the non-urothelial recurrence categories (P<0.0001 and P<0.0001, respectively). Among the other relevant descriptive pre-operative characteristics in the multivariate analysis, only non-urothelial recurrence remained associated with a worse CSS [P=0.002; hazard ratio (HR) 9.512]. The results show that urothelial recurrence has a minimal prognostic value in patients with UTUC managed by RNU with an ipsilateral bladder cuff.


Related Articles

  • Immediate, early (6 weeks) and delayed loading (3 months) of single implants: 4-month post-loading from a multicenter pragmatic randomised controlled trial. Esposito, Marco; Siormpas, Konstantinos; Mitsias, Miltiadis; Bechara, Soheil; Trullenque-Eriksson, Anna; Pistilli, Roberto // European Journal of Oral Implantology;2016, Vol. 9 Issue 3, p249 

    Purpose: To compare the clinical outcome of single, partial and full fixed implant-supported prostheses immediately loaded (within 48 h), early loaded at 6 weeks and conventionally loaded at 3 months (delayed loading). Materials and methods: Eighty-one patients (27 requiring single implants, 27...

  • A 10-year report from a multicentre randomised controlled trial: Immediate non-occlusal versus early loading of dental implants in partially edentulous patients. Zuffetti, Francesco; Esposito, Marco; Galli, Fabio; Capelli, Matteo; Grandi, Giovanni; Testori, Tiziano // European Journal of Oral Implantology;2016, Vol. 9 Issue 3, p219 

    Purpose: To compare peri-implant bone and soft-tissue levels of immediate non-occlusally loaded versus non-submerged early loaded implants in partially edentulous patients 10 years after loading. Materials and methods: Fifty-two patients were randomised in five Italian private practices: 25 in...

  • A rare and unusual case of isolated cerebellar metastasis from a non-muscle invasive transitional cell carcinoma of bladder. D’Souza, Nigel; Khan, Muhammad J.; Robinson, Simon; Motiwala, Hanif // JRSM Shorts;Jun2011, Vol. 2 Issue 6, p1 

    The article presents a case study of a 69-year-old woman with painless visible haematuria and enterococcus urinary tract infection. The patient underwent a transurethral resection of her bladder tumour and diagnosed with metastatic transitional cell carcinoma of bladder in the cerebellar tissue...

  • Data Support LNU for Urothelial-Cell Carcinoma.  // Renal & Urology News;Sep2011, Vol. 10 Issue 9, p17 

    The article reports on the findings of the study conducted by Grant D. Stewart and colleagues which reveals that laparoscopic and open nephroureterectomy for upper urinary tract urothelial-cell carcinoma (UUT-UCC) which are uncommon but aggressive malignancies associated with long-term outcomes.

  • Reply to the letter of Zattoni et al. Kato, Katsuhiko // European Journal of Nuclear Medicine & Molecular Imaging;Mar2016, Vol. 43 Issue 3, p578 

    A response from N. Sassa et al, to a letter to the editor about their article "Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study" in the December 2014 issue is presented.

  • Biosimilars and the extrapolation of indications for inflammatory conditions. Tesser, John R. P.; Furst, Daniel E.; Jacobs, Ira // Biologics: Targets & Therapy;Feb2017, Vol. 11, p5 

    Extrapolation is the approval of a biosimilar for use in an indication held by the originator biologic not directly studied in a comparative clinical trial with the biosimilar. Extrapolation is a scientific rationale that bridges all the data collected (ie, totality of the evidence) from one...

  • CONGENITAL METHEMOGLOBINEMIA TYPE 2 - A RARE CASE REPORT. Nellicka, Shinas; John, Abraham; Abraham, Vivin // Pediatric Oncall Journal;Apr-Jun2017, Vol. 14 Issue 2, p45 

    The article presents a case study of a 1 year old female child born with bluish discoloration of skin and mucosa. The patient was diagnosed with congenital methemoglobinemia type II as well as central cyanosis and microcephaly. The patient had global developmental delay with hypertonia and brisk...

  • IS IT REALLY PULMONARY TB. Meha, Tanvi; Raja, Anshul; Sinha, Arbind Kumar // Pediatric Oncall Journal;Apr-Jun2017, Vol. 14 Issue 2, p49 

    The article presents a case study of a 3-year-old female child, who was presented to pediatric outpatient department (OPD) with fever. The patient was diagnosed with tuberculosis (TB) based on her chest x-ray by a physician. The patient was administered with anti-tuberculous therapy (ATT) due to...

  • SPLENECTOMY WITHOUT PRIOR VACCINATION. Shah, Ira // Pediatric Oncall Journal;Apr-Jun2017, Vol. 14 Issue 2, p51 

    The article presents a case study of a 9-year-old boy presented with pain in left part of abdomen. The patient was diagnosed with splenic cystic lesions without prior vaccination. The patient was administered for emergency splenectomy for its morbidity of leading to immunodeficiency. It stresses...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics