C-reactive protein is a predictor of complications after elective laparoscopic colorectal surgery: five-year experience

Poskus, Eligijus; Karnusevicius, Ignas; Andreikaite, Gintare; Mikalauskas, Saulius; Poskus, Tomas; Strupas, Kestutis
July 2015
Videosurgery & Other Miniinvasive Techniques / Wideochirurgia i;2015, Vol. 10 Issue 3, p418
Academic Journal
Introduction: With the development and improvement of laparoscopic surgery, procedures have become common. However, post-operative complications occur when patients are released from hospital. These complications increase patients' morbidity and mortality. They also lead to re-hospitalization, an extended recovery period, and an increase in the cost of treatment. Aim: To evaluate and determine the prognostic properties of C-reactive protein in the early diagnosis of postoperative complications after a laparoscopic colon resection. Material and methods: The prospective study included patients who underwent laparoscopic colorectal surgery in 2010-2014. The patients were divided into two groups - uncomplicated ones and those with complications. C-reactive protein concentrations in their blood serum were measured on the 2nd, 4th and 6th day after surgery. Logistic regression analysis was used to evaluate the relation between C-reactive protein values measured on the 2nd, 4th and 6th postoperative day and related complications. Receiver operating characteristic curves were used to determine the sensitivity and specificity of each C-reactive protein value measured on the 2nd, 4th and 6th postoperative day. Results: One hundred and six patients were included in the trial; 14 of them had complications. On the second day, a C-reactive protein cut-off value of 88.6 mmol/l provided the highest sensitivity and specificity for predicting evolving complications, being 71.4% and 84.8% respectively (p = 0.003). The significant predictive cut-off value decreases and becomes more sensitive and specific each post-operative day. Conclusions: It is possible to detect developing post-operative complications early on by monitoring C-reactive protein concentration levels in the blood serum on the 2nd, 4th, and 6th post-operative days.


Related Articles

  • C-Reactive Protein 2 Days After Laparoscopic Gastric Bypass Surgery Reliably Indicates Leaks and Moderately Predicts Morbidity. Warschkow, Rene; Tarantino, Ignazio; Folie, Patrick; Beutner, Ulrich; Schmied, Bruno; Bisang, Philipp; Schultes, Bernd; Thurnheer, Martin // Journal of Gastrointestinal Surgery;Jun2012, Vol. 16 Issue 6, p1128 

    Background: The aim of the present study was to evaluate whether serum C-reactive protein (CRP) is a useful predictor of early post-operative complications, particularly of intestinal leaks after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery. Methods: The present study was a...

  • What is the diagnostic value of C-reactive protein for the prediction and the exclusion of postoperative infectious complication after colorectal surgery? Chaudhury, Prosanto K.; Jeschke, Marc G.; Monson, John R.; McKenzie, M. // Canadian Journal of Surgery;Dec2014, Vol. 57 Issue 6, p417 

    Objective: To assess the predictive value of C-reactive protein (CRP) level for postoperative infectious complications after colorectal surgery. Data source: PubMed. Study selection: The article included all studies that analyzed the diagnostic accuracy of CRP for predicting postoperative...

  • Markers of Perioperative Bowel Complications in Colorectal Surgery Patients. Hyšpler, Radomír; Tichá, Alena; Kaška, Milan; Žaloudková, Lenka; Plíšková, Lenka; Havel, Eduard; Zadák, Zdeněk // Disease Markers;12/15/2015, p1 

    Colorectal cancer is a clinical condition whose treatment often involves intestinal resection. Such treatment frequently results in two major gastrointestinal complications after surgery: anastomotic leakage and prolonged ileus. Anastomotic leakage is a serious complication which, more often...

  • A Novel Approach to Major Surgery: Tracking Its Pathophysiologic Footprints. Mantziari, Styliani; Hübner, Martin; Coti-Bertrand, Pauline; Pralong, François; Demartines, Nicolas; Schäfer, Markus // World Journal of Surgery;Nov2015, Vol. 39 Issue 11, p2641 

    Background: To study the 'metabolic profile' of different surgical procedures and correlate it with pertinent surgical details and postoperative complications. Methods: We conducted a prospective pilot study of 70 patients, ten for each of the seven following groups: (1) laparoscopic...

  • Diagnostic markers of postoperative morbidity after laparoscopic Roux-en-Y gastric bypass for obesity. Romain, Benoît; Chemaly, Rodrigue; Meyer, Nicolas; Chilintseva, Natalia; Triki, Elhocine; Brigand, Cécile; Rohr, Serge // Langenbeck's Archives of Surgery;Apr2014, Vol. 399 Issue 4, p503 

    Purpose: The main objective of this study was to detect subacute complications that can arise from laparoscopic Roux-en-Y gastric bypass and take a rational approach to manage these complications. Methods: A prospective observational study was performed from November 2010 to December 2012. All...

  • Monitoring c-reactive protein after laparoscopic colorectal surgery excludes infectious complications and allows for safe and early discharge. Adamina, Michel; Warschkow, Rene; Näf, Franziska; Hummel, Bianka; Rduch, Thomas; Lange, Jochen; Steffen, Thomas // Surgical Endoscopy;Oct2014, Vol. 28 Issue 10, p2939 

    Background: Early detection of infectious complications is urgently needed in the era of DRG-based compensation. This work assessed the diagnostic accuracy of c-reactive protein (CRP) level in the detection of infectious complications after laparoscopic colorectal resection. Methods:...

  • Factors predicting the occurrence of a gastrojejunal anastomosis leak following gastric bypass. Mickevicius, Antanas; Sufi, Pratik; Heath, Dugal // Videosurgery & Other Miniinvasive Techniques / Wideochirurgia i;Sep2014, Vol. 9 Issue 3, p436 

    Introduction: Occurrence of anastomotic leaks following Roux-en-Y gastric bypass (RYGB), arising principally from the gastro-jejunal anastomosis, is associated with significant morbidity and mortality. Their early detection and treatment is essential. However, a significant number of...

  • Colonic Foreign Body Retrieval Using a Modified TAMIS Technique with Standard Instruments and Trocars. Cawich, Shamir O.; Mohammed, Fawwaz; Spence, Richard; Albert, Matthew; Naraynsingh, Vijay // Case Reports in Emergency Medicine;4/7/2015, Vol. 2015, p1 

    Background. Reports of retained colorectal foreign bodies (CFBs) are no longer considered uncommon. We present a case where a retained CFB was retrieved using a modified TAMIS technique using standard instruments and trocars. Case Report. A 52-year-old man presented with a CFB. We report our...

  • Objective assessment of technique in laparoscopic colorectal surgery: What are the existing tools? Foster, J.; Francis, N. // Techniques in Coloproctology;Jan2015, Vol. 19 Issue 1, p1 

    Assessment can improve the effectiveness of surgical training and enable valid judgments of competence. Laparoscopic colon resection surgery is now taught within surgical residency programs, and assessment tools are increasingly used to stimulate formative feedback and enhance learning. Formal...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics