TITLE

Usefulness of elevated red cell distribution width for predicting systemic inflammatory response syndrome after extracorporeal circulation

AUTHOR(S)
Özeren, M.; Aytaçoğlu, B.; Vezir, Ö; Karaca, K.; Akın, R.; Sucu, N.
PUB. DATE
October 2015
SOURCE
Perfusion;Oct2015, Vol. 30 Issue 7, p580
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: Cardiac surgical operations performed by using extracorporeal circulation (ECC) lead to a systemic inflammatory response (SIR). Sometimes SIR may turn into a severe state, the systemic inflammatory response syndrome (SIRS) that usually has a poor outcome with no specific clinical tools described for its prediction. Red cell distribution width (RDW) is a routine hematological parameter. It has been proposed as a marker of morbidity and mortality in various clinical conditions. We aimed to investigate the relationship between high RDW and SIRS which is triggered by ECC. Methods: Eleven hundred consecutive patients who underwent elective heart surgery with the use of ECC were retrospectively analyzed. A total of 19 patients fulfilled the described SIRS criteria and 20 consecutive patients were selected as the control group. RDW and other laboratory parameters, preoperative clinical status, operative data and postoperative data were compared between the SIRS and the control groups. Results: Baseline characteristics of the patient groups were similar. Significant mortality was found in the SIRS group; 18 (94.73%) patients and 2 (10%) patients in the control group (p<0.002). RDW was found to be significantly higher in the SIRS group vs the control group (15.02±2.03 vs 13.01±1.93, respectively, p<0.003). Multiple logistic regression analyses showed an association between high RDW levels and SIRS development (OR for RDW levels exceeding 13.5%; 95% confidence limits of 1.0-1.3; p<0.04). Total operation time and the need for inotropic support were also found to be significant against the SIRS group (p=0.049). Conclusion: Increased RDW was significantly associated with increased risk of SIRS after ECC. The results of this study suggest that paying attention to RDW might provide valuable clinical information for predicting SIRS development among patients who are candidates for open heart surgery, without incurring additional costs.
ACCESSION #
110353132

 

Related Articles

  • Total parenteral nutrition-associated cholestasis and risk factors in preterm infants. Alkharfy, Turki M.; Ba‑Abbad, Rubana; Hadi, Anjum; Sobaih, Badr H.; AlFaleh, Khalid M. // Saudi Journal of Gastroenterology;Sep/Oct2014, Vol. 20 Issue 5, p293 

    Background/Aim: Development of hepatic dysfunction is a well‑recognized complication of total parenteral nutrition in preterm infants. Previous studies reported the incidence of total parenteral nutrition-associated cholestasis and described possible contributing factors to its...

  • GAPSS: the Global Anti-Phospholipid Syndrome Score. Sciascia, Savino; Sanna, Giovanni; Murru, Veronica; Roccatello, Dario; Khamashta, Munther A.; Bertolaccini, Maria Laura // Rheumatology;Aug2013, Vol. 52 Issue 8, p1397 

    Objective. To develop and validate a risk score [global APS score (GAPSS)] derived from the combination of independent risk for thrombosis and pregnancy loss (PL), taking into account the aPL profile, conventional cardiovascular risk factors and the autoimmune antibody profile.Methods. This...

  • Preoperative White Blood Cell Count and Risk of 30-Day Readmission after Cardiac Surgery. Brown, Jeremiah R.; Clive Landis, R.; Chaisson, Kristine; Ross, Cathy S.; Dacey, Lawrence J.; Boss Jr., Richard A.; Helm, Robert E.; Horton, Susan R.; Hofmaster, Patricia; Jones, Cheryl; Desaulniers, Helen; Westbrook, Benjamin M.; Duquette, Dennis; LeBlond, Kelly; Quinn, Reed D.; Magnus, Patrick C.; Malenka, David J.; DiScipio, Anthony W. // International Journal of Inflammation;2013, p1 

    Approximately 1 in 5 patients undergoing cardiac surgery are readmitted within 30 days of discharge. Among the primary causes of readmission are infection and disease states susceptible to the inflammatory cascade, such as diabetes, chronic obstructive pulmonary disease, and gastrointestinal...

  • Use of a 12-week observational period for predicting low disease activity at 52 weeks in RA patients treated with abatacept: a retrospective observational study based on data from a Japanese multicentre registry study. Nobunori Takahashi; Toshihisa Kojima; Atsushi Kaneko; Daihei Kida; Yuji Hirano; Takayoshi Fujibayashi; Yuichiro Yabe; Hideki Takagi; Takeshi Oguchi; Hiroyuki Miyake; Takefumi Kato; Naoki Fukaya; Masatoshi Hayashi; Seiji Tsuboi; Yasuhide Kanayama; Koji Funahashi; Masahiro Hanabayashi; Shinya Hirabara; Shuji Asai; Yutaka Yoshioka // Rheumatology;May2015, Vol. 54 Issue 5, p854 

    Objective. Only a few studies have assessed predictive factors for the long-term efficacy of abatacept. This study aimed to provide clinical evidence of an adequate observational period for predicting low disease activity (LDA) achievement at 52 weeks in RA patients treated with abatacept....

  • The relationship between the neutrophil–lymphocyte ratio and the coronary collateral circulation in patients with chronic total occlusion. Kalkan, ME; Şahin, M; Kalkan, AK; Güler, A; Taş, MH; Bulut, M; Demir, S; Acar, RD; Arslantaş, U; Öztürkeri, B; Güler, Y; Akçakoyun, M // Perfusion;Jul2014, Vol. 29 Issue 4, p360 

    The article reports on a study of the link between the neutrophil-lymphocyte ratio (NLR) and coronary collateral circulation (CCC) development in patients that have coronary chronic total occlusion (CTO). Topics include the simplicity and cost effectiveness of the NLR method, the review of a...

  • Development and validation of a delirium predictive score in older people. Carrasco, Marcela P.; Villarroel, Luis; Andrade, Maricarmen; Calderón, Jorge; González, Matías // Age & Ageing;May2014, Vol. 43 Issue 3, p346 

    Background: delirium is frequently under diagnosed in older hospitalised patients. Predictive models have not been widely incorporated in clinical practice.Objective: to develop and validate a predictive score for incident delirium.Design and setting: two consecutive observational prospective...

  • Blood pressure-to-height ratio as a screening measure for identifying children with hypertension. Qiang Lu; Chunming Ma; Fuzai Yin; Rui Wang; Donghui Lou; Xiaoli Liu // European Journal of Pediatrics. Supplement;2013, Vol. 172, p99 

    The present study evaluated the feasibility and accuracy of the blood pressure-to-height ratio (BPHR) and proposed the optimal thresholds of BPHR for identifying hypertension in Han children aged 7-12 years. In 2011, anthropometric measurements were assessed in a cross-sectional population-based...

  • Clinical Predictors of Resectability of Pancreatic Adenocarcinoma. Almadi, Majid A.; Alharbi, Othman; Azzam, Nahla; Altayeb, Mohannad; Javed, Moammed; Alsaif, Faisal; Hassanain, Mazen; Alsharabi, Abdulsalam; Al-Saleh, Khalid; Aljebreen, Abdulrahman M. // Saudi Journal of Gastroenterology;Nov/Dec2013, Vol. 19 Issue 6, p278 

    Background/Aims: Identifying patient.related factors as well as symptoms and signs that can predict pancreatic cancer at a resectable stage, which could be used in an attempt to identify patients at an early stage of pancreatic cancer that would be appropriate for surgical resection and those at...

  • Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients. Kawamoto, Ryuichi; Katoh, Tateaki; Kusunoki, Tomo; Ohtsuka, Nobuyuki // ISRN Endocrinology;2013, p1 

    Many studies have shown that carotid intima-media thickness (IMT) is associated with cardiovascular disease (CVD). Although it remains inconclusive whether assessment of carotid IMT is useful as a screening test for CVD in Japanese diabetic patients, a total of 271 patients (151 men aged 66 } 10...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics