Diagnostic performance of ADCs in different ROIs for breast lesions

Wei Zhang; Guan-Qiao Jin; Jun-Jie Liu; Dan-Ke Su; Ning-Bin Luo; Dong Xie; Shao-Lv Lai; Xiang-Yang Huang; Wei-Li Huang
October 2015
International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 8, p12096
Academic Journal
Objective: The purpose of this study was to explore the diagnostic performance of apparent diffusion coefficient (ADC) values for breast lesions by different measuring methods and find out the optimum measuring method. Methods: ADCW-mean and ADCW-min were obtained by whole-measurement method, while ADCmean and ADCmin were extracted by spot-measurement method. Four ADCs were analyzed by One-way ANOVA and Independent T-test. The diagnostic performances of these four ADCs were calculated by receiver operating characteristics (ROC) curves and the area under the curves (AUC) were compared through Z-test. Results: For the whole-measurement method, there were significant differences between malignant and benign lesions (ADCW-mean=1.014±0.197 for malignant, ADCWmean =1.650±0.348 for benign, F=37.511, P<0.001; ADCW-min=0.627±0.144 for malignant, ADCW-min=1.245±0.290 for benign, F=41.446, P<0.001), as well as the spot-measurement method (ADCmean=1.010±0.234 for malignant, ADCmean=1.648±0.392 for benign, F=34.580, P<0.001; ADCmin=0.817±0.203 for malignant, ADCmin=1.411±0.357 for benign, F=40.039, P<0.001). The optimal diagnostic threshold of ADCW-mean, ADCW-min, ADCmean, and ADCmin values were 1.223×10-3 mm²/s, 0.897×10-3 mm²/s, 1.315×10-3 mm2/s, and 1.111×10-3 mm²/s, respectively. ROC curves indicated that the AUC for ADCW-min (0.969) was statistically significant higher than the AUC for ADCW-mean (0.940; Z=2.473, p=0.013), ADCmean (0.919; Z=3.691, P=0.000), and ADCmin (0.928; Z=3.634, P=0.000). The AUC for ADCWmean was also significantly higher than the AUC for ADCmean (Z=2.863, P=0.004). Conclusion: The results provided evidence that the most reliable and accurate value in demonstrating the limitation of diffusion may be ADCW-min, and it has the highest diagnostic value in distinguishing breast lesions from malignant to benign.


Related Articles

  • Breast cancer screening and diagnosis in the 21st century within the U.K. Murray, Philip J.; Wivell, Glynis; Denton, Erika // Post Reproductive Health;Sep2015, Vol. 21 Issue 3, p105 

    In the UK, breast cancer represents the most commonly diagnosed cancer in females and carries with it a significant morbidity and mortality. An established national screening programme is in place to identify those with the disease at an early stage in order to optimise treatment and prognosis....

  • KONYA KANSER ERKEN TEÅžHÄ°S -- TARAMA VE EĞİTÄ°M MERKEZÄ°(KETEM) ÇALIÅžANLARININ EĞİTÄ°MÄ°NÄ°N MEME KANSERÄ° TANI VE TEDAVÄ° SÃœRECÄ°NE ETKÄ°SÄ°. Eryılmaz, Mehmet Ali; Karahan, Ömer; Civcik, Seher; Büyük, Eylem; Tuncer, Murat; Özgül, Nejat; Özmen, Vahit // Meme Sagligi Dergisi / Journal of Breast Health;2012, Vol. 8 Issue 1, p23 

    Purpose: To investigate the effects of information acquired by KETEM's staff on the diagnosis and treatment of breast cancer. Patients and Methods: Between 2007-2010, BSE was first taught and performed in all women. USG was performed for those ≤40, and MG for those ≥40; also, USG and...

  • Assessing the effect of a true-positive recall case in screening mammography: does perceptual priming alter radiologists' performance? LEWIS, S. J.; MELLO-THOMS, C. R.; BRENNAN, P. C.; LEE, W.; TAN, A.; MCENTEE, M. F.; EVANOFF, M.; PIETRZYK, M.; REED, W. M. // British Journal of Radiology;Jul2014, Vol. 87 Issue 1039, p1 

    Objective: To measure the effect of the insertion of less-difficult malignant cases on subsequent breast cancer detection by breast imaging radiologists. Methods: The research comprises two studies. Study 1: 8 radiologists read 2 sets of images each consisting of 40 mammographic cases. Set A...

  • Does Preoperative Magnetic Resonance Imaging Beneficially Alter Surgical Management of Invasive Lobular Carcinoma? LAU, BRIANA; ROMERO, LINA M. // American Surgeon;Oct2011, Vol. 77 Issue 10, p1368 

    The role of breast magnetic resonance imaging (MRI) in patients with newly diagnosed breast cancer remains controversial. The objective of this study is to determine the impact of pre-operative breast MRI on patients with biopsy-proven invasive lobular carcinoma (ILC) initially deemed eligible...

  • Breast Magnetic Resonance Imaging and Its Impact on the Surgical Treatment of Breast Cancer. Tsina, Georgia; Simon, Philippe // Obstetrics & Gynecology International;2014, p1 

    Breast MRI focuses on the detection of multifocality, multicentricity, and bilaterality of newly diagnosed breast cancer. A retrospective study was carried out on 833 patients that were diagnosed and treated for breast cancer between January 2002 and December 2011. Patients were divided into two...

  • An evaluation of the prognostic model PREDICT using the POSH cohort of women aged ⩽40 years at breast cancer diagnosis. Maishman, T; Copson, E; Stanton, L; Gerty, S; Dicks, E; Durcan, L; Wishart, G C; Pharoah, P; Eccles, D // British Journal of Cancer;3/17/2015, Vol. 112 Issue 6, p983 

    Background:Breast cancer is the most common cancer in younger women (aged ⩽40 years) in the United Kingdom. PREDICT (http://www.predict.nhs.uk) is an online prognostic tool developed to help determine the best available treatment and outcome for early breast cancer. This study was conducted...

  • Male Breast Cancer. Yalaza, Metin; İnan, Aydın; Bozer, Mikdat // Meme Sagligi Dergisi / Journal of Breast Health;Jan2016, Vol. 12 Issue 1, p1 

    Male breast cancer (MBC) is a rare disease, accounting for less than 1% of all breast cancer diagnoses worldwide. Although breast carcinomas share certain characteristics in both genders, there are notable differences. Most studies on men with breast cancer are very small. Thus, most data on...

  • Risking 'Safety': Breast Cancer, Prognosis, and the Strategic Enterprise of Life. Ehlers, Nadine // Journal of Medical Humanities;Mar2016, Vol. 37 Issue 1, p81 

    Living in modern biopolitical risk culture might be seen as synonymous with living in prognosis time, in the sense that risk of illness is endlessly forecast (prognosticated) in the broad social arena. 'Safety,' in this context, is framed as the anticipatory guarding against risk or disease in...

  • Squamous cell carcinoma of the breast: particularity and clinical management. Xiao-Le Chen; Jie Luo; Fa-Liang Xu // International Journal of Clinical & Experimental Medicine;2016, Vol. 9 Issue 7, p14167 

    Objective: The clinical behavior and prognosis of breast squamous cell carcinoma (SCC) have not been fully characterized; this study aimed to further explore these issues. Methods: Twenty-three patients were identified as having primary SCC (PSCC) or metaplastic SCC (MSCC). Their...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics