TITLE

mTOR 信号通路调控糖尿病肾病肾小球肥大的机制及中药的干预作用

AUTHOR(S)
杨晶晶; 黄燕如; 万毅刚; 沈山梅; 毛志敏; 吴薇; 姚建
PUB. DATE
August 2015
SOURCE
Zhongguo Zhongyao Zazhi / China Journal of Chinese Materia Medic;Aug2015, Vol. 40 Issue 16, p3125
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
110225154

 

Related Articles

  • mTOR: a pharmacologic target for autophagy regulation. Young Chul Kim; Kun-Liang Guan; Kim, Young Chul; Guan, Kun-Liang // Journal of Clinical Investigation;Jan2015, Vol. 125 Issue 1, p25 

    mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of cues, and its signaling pathway is deregulated in many human diseases. mTOR also plays a crucial role in regulating autophagy. This Review...

  • Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2. Feldman, Morris E.; Apsel, Beth; Uotila, Aino; Loewith, Robbie; Knight, Zachary A.; Ruggero, Davide; Shokat, Kevan M. // PLoS Biology;Feb2009, Vol. 7 Issue 2, pe1000038 

    Cells rely on the mammalian target of rapamycin kinase (mTOR) to sense growth factors. Inhibition of all forms of mTOR using newly developed inhibitors of its active site reveals new insights into the function of two mTOR-containing protein complexes and their potential as therapeutic targets.

  • Mammalian target of rapamycin and head and neck squamous cell carcinoma. Yu-Min Liao; Charles Kim; Yun Yen // Head & Neck Oncology;2011, Vol. 3 Issue 1, p1 

    Head and neck squamous cell carcinoma (HNSCC), a significant cause of cancer deaths worldwide, has multiple stepwise malignant evolutions. Mammalian target of rapamycin (mTOR) plays a critical role in tumor development, invasion, metastasis and angiogenesis that impact local recurrence and...

  • Cancer: Profiling the translational targets of mTOR signalling. Burgess, Darren J. // Nature Reviews Genetics;Apr2012, Vol. 13 Issue 4, p223 

    The article discusses a study which investigates the translational regulator of the mammalian target of rapamycin (mTOR) kinase by profiling ribosomal RNA from an mTOR-hyperactivated prostate cancer cell line.

  • Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas. Maniscalco, Lorella; Millán, Yolanda; Iussich, Selina; Denina, Mauro; Sánchez-Céspedes, Raquel; Gattino, Francesca; Biolatti, Bartolomeo; Sasaki, Nobuo; Nakagawa, Takayuki; Di Renzo, Maria Flavia; de las Mulas, Juana Martín; De Maria, Raffaella // BMC Veterinary Research;5/1/2013, Vol. 9 Issue 1, Special section p1 

    Background: Triple negative breast cancer (TNBC) in humans is defined by the absence of oestrogen receptor (ER), progesterone receptor (PR) and HER2 overexpression. Mammalian target of rapamycin (mTOR) is overexpressed in TNBC and it represents a potential target for the treatment of this...

  • Targeted Inhibition of mTOR Signaling Improves Sensitivity of Esophageal Squamous Cell Carcinoma Cells to Cisplatin. Guiqin Hou; Shuai Yang; Yuanyuan Zhou; Cong Wang; Wen Zhao; Zhaoming Lu // Journal of Immunology Research;2014, p1 

    mTOR is an evolutionarily conserved serine-threonine kinase with a central role in cell growth, invasion, and metastasis of tumors, and is activated in many cancers. The aims of this study were to investigate the expression of mTOR in ESCC tissues and its relationship with progression of ESCC...

  • Advanced Research of mTOR and Lung Carcinoid Tumors. Zixuan Zhang; Mengzhao Wang // Chinese Journal of Lung Cancer;Jan2013, Vol. 16 Issue 1, p43 

    Mammalian target of rapamycin (mTOR), a main protein kinase in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signaling pathway, is an important intracellular mediator involved in multiple celluar functions including proliferation, differentiation, apoptosis, tumorigenesis, and angiogenesis....

  • Combining allografting with mTOR inhibitors for metastatic renal cell cancer. Bregni, M; Vitali, G; Peccatori, J // Bone Marrow Transplantation;Dec2011, Vol. 46 Issue 12, p1586 

    A letter to the editor is presented regarding combination of allograft with mTOR inhibitors for metastatic renal cell cancer.

  • Your path to performance.  // Drug Discovery & Development;Sep2008, Vol. 11 Issue 9, p41 

    The article reports on the critical role played by the Akt/mTOR pathway in the control of apoptosis and the regulation of cellular proliferation.

  • mTOR inhibitors: A novel class of anti-cancer agents. Riaz, Haris; Riaz, Talha; Hussain, Syed A. // Infectious Agents & Cancer;2012, Vol. 7 Issue 1, p1 

    A letter to the editor is presented on the effectiveness of Mammalian Target of Rapamycin (mTOR) inhibitors in the treatment of cancer.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics