Use of High-Flow Nasal Cannula for Acute Dyspnea and Hypoxemia in the Emergency Department

Nuttapol Rittayamai; Jamsak Tscheikuna; Nattakarn Praphruetkit; Sunthorn Kijpinyochai
October 2015
Respiratory Care;Oct2015, Vol. 60 Issue 10, p1377
Academic Journal
BACKGROUND: Acute dyspnea and hypoxemia are 2 of the most common problems in the emergency room. Oxygen therapy is an essential supportive treatment to correct these issues. In this study, we investigated the physiologic effects of high-flow nasal oxygen cannula (HFNC) compared with conventional oxygen therapy (COT) in subjects with acute dyspnea and hypoxemia in the emergency room. METHODS: A prospective randomized comparative study was conducted in the emergency department of a university hospital. Forty subjects were randomized to receive HFNC or COT for 1 h. The primary outcome was level of dyspnea, and secondary outcomes included change in breathing frequency, subject comfort, adverse events, and rate of hospitalization. RESULTS: Common causes of acute dyspnea and hypoxemia were congestive heart failure, asthma exacerbation, COPD exacerbation, and pneumonia. HFNC significantly improved dyspnea (2.0 ±1.8 vs 3.8 ± 2.3, P = .01) and subject comfort (1.6 ± 1.7 vs 3.7 ± 2.4, P = .01) compared with COT. No statistically significant difference in breathing frequency was found between the 2 groups at the end of the study. HFNC was well tolerated, and no serious adverse events were found. The rate of hospitalization in the HFNC group was lower than in the COT group, but there was no statistically significant difference (50% vs 65%, P = .34). CONCLUSIONS: HFNC improved dyspnea and comfort in subjects presenting with acute dyspnea and hypoxemia in the emergency department. HFNC may benefit patients requiring oxygen therapy in the emergency room.


Related Articles

  • Comparison of the Canadian CT head rule and the new orleans criteria in patients with minor head injury. Kavalci, Cemil; Aksel, Gokhan; Salt, Omer; Yilmaz, M. Serkan; Demir, Ali; Kavalci, Gulsüm; Akbuga, Betul; Altinbilek, Ertugrul; Durdu, Tamer; Yel, Cihat; Durukan, Polat; Isik, Bahattin // World Journal of Emergency Surgery;2014, Vol. 9 Issue 1, p1 

    Aim The aim of the study was to compare the New Orleans Criteria and the New Orleans Criteria according to their diagnostic performance in patients with mild head injury. Methods The study was designed and conducted prospectively after obtaining ethics committee approval. Data was collected...

  • Factors delaying hospital arrival of patients with acute stroke. Ashraf, V. V.; Maneesh, M.; Praveenkumar, R.; Saifudheen, K.; Girija, A. S. // Annals of Indian Academy of Neurology;Apr2015, Vol. 18 Issue 2, p162 

    Background: Low rates of thrombolysis for ischemic stroke in India and other developing countries have been attributed to delays in presentation to the hospital. Materials and Methods: A prospective study was carried out during a 12-month period ending December 2012 in the department of...

  • The coast and benefits of helicopter emergency medical services instead of the ground unit in traumatic patients: A cost-effectiveness analysis. Akhtari, Amin Shams; Jafari, Naghmeh Sadat; Kariman, Hamid; Amini, Afshin; Monsef, Vahid; Noorizadeh, Mohamad; Gholizadeh, Neda // Health (1949-4998);May2013, Vol. 5 Issue 5, p903 

    Study objective: Aero medical crews offer an advanced level of practice and rapid transport to definitive care; however, their efficacy remains unproven. Previous studies have used relatively small sample sizes or have been unable to adequately control the effect of other potentially influential...

  • Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study. Horvat, Pia; Kubinova, Ruzena; Pajak, andrzej; Tamosiunas, abdonas; Schöttker, Ben; Pikhart, Hynek; Peasey, anne; Kozela, Magdalena; Jansen, Eugene; Singh-Manoux, archana; Bobak, Martin // Dementia & Geriatric Cognitive Disorders;Dec2016, Vol. 42 Issue 5/6, p297 

    Background/Aims: Oxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age. Methods: Subjects aged...

  • Hormonal Contraception and Risk of Psychiatric and Other Noncommunicable Diseases in HIV-Infected Women. Castilho, Jessica L.; Jenkins, Cathy A.; Shepherd, Bryan E.; Bebawy, Sally S.; Turner, Megan; Sterling, Timothy R.; Melekhin, Vlada V. // Journal of Women's Health (15409996);Jun2015, Vol. 24 Issue 6, p481 

    Background: Hormonal contraception use is common among human immunodeficiency virus (HIV)-infected women. Risk of psychiatric and other noninfectious complications of hormonal contraception use has not been described in this population. Methods: We performed a retrospective cohort study of...

  • Working hours and incidence of metabolic syndrome and its components in a Mediterranean cohort: the SUN project. Pimenta, Adriano M.; Bes-Rastrollo, Maira; Sayon-Orea, Carmen; Gea, Alfredo; Aguinaga-Ontoso, Enrique; Lopez-Iracheta, Roberto; Martinez-Gonzalez, Miguel A. // European Journal of Public Health;Aug2015, Vol. 25 Issue 4, p683 

    Background: Metabolic syndrome (MetS) is an important and priority public health problem globally. Long working hours have been proposed as a modifiable risk factor for MetS, despite sparse epidemiological evidence. Thus, the aim of this study was to prospectively evaluate the associations...

  • The value of Serum BNP for diagnosis of intracranial injury in minor head trauma. Demir, Ali; Kavalci, Cemil; Yilmaz, Muhittin Serkan; Yilmaz, Fevzi; Durdu, Tamer; Ceyhan, Mehmet Ali; Alagoz, Fatih; Yel, Cihat // World Journal of Emergency Surgery;2014, Vol. 9 Issue 1, p1 

    Objective Head injury is the main cause of death among individuals younger than 45 years old. Cranial Computerized tomography (CT) is commonly used for diagnosis of head injury. Brain Natriuretic Peptide (BNP) is a peptide originally isolated from brain ventricles. The main aim of this study is...

  • Testing a Theory-Based Model of Suicidality in a Community Sample. Campos, Rui C.; Holden, Ronald R. // Omega: Journal of Death & Dying;Dec2016, Vol. 74 Issue 2, p119 

    The aim of the present study is to test a theory-based model of suicide in a low-risk nonclinical sample. A community sample of convenience of 200 adults, 102 men and 98 women, responded to the Depressive Experiences Questionnaire, the Center for the Epidemiologic Studies of Depression Scale,...

  • Heated and Humidified High-Flow Oxygen Therapy Reduces Discomfort During Hypoxemic Respiratory Failure. Cuquemelle, Elise; Tai Pham; Papon, Jean-François; Louis, Bruno; Danin, Pierre-Eric; Brochard, Laurent // Respiratory Care;Oct2012, Vol. 57 Issue 10, p1571 

    BACKGROUND: Non-intubated critically ill patients are often treated by high-flow oxygen for acute respiratory failure. There is no current recommendation for humidification of oxygen devices. METHODS: We conducted a prospective randomized trial with a final crossover period to compare nasal...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics