Gene Therapy for Heart Failure: Back to the Bench

Ylä-Herttuala, Seppo
October 2015
Molecular Therapy;Oct2015, Vol. 23 Issue 10, p1551
Academic Journal
The author reflects on the use of gene therapy for the treatment of heart failure. He mentions pharmaceutical firm Celladon Corp. which announced that its Mydicar adeno-associated viral vector 1 (AAV1)-expressing sarcoplasmic reticulum calcium ATPase drug for heart failure has failed in the second phase of the clinical trial. Also discussed are the factors that contributed to Celladon's failure and the need for developing efficient targeted vectors and delivery methods for heart failure.


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