TITLE

Translating the effects of mTOR on secretory senescence

AUTHOR(S)
Tomimatsu, Kosuke; Narita, Masashi
PUB. DATE
October 2015
SOURCE
Nature Cell Biology;Oct2015, Vol. 17 Issue 10, p1230
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization.
ACCESSION #
110030980

 

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