Translating the effects of mTOR on secretory senescence

Tomimatsu, Kosuke; Narita, Masashi
October 2015
Nature Cell Biology;Oct2015, Vol. 17 Issue 10, p1230
Academic Journal
Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization.


Related Articles

  • Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes. Livingstone, Mark; Sikström, Kristina; Robert, Philippe A.; Uzé, Gilles; Larsson, Ola; Pellegrini, Sandra // PLoS ONE;7/24/2015, Vol. 10 Issue 7, p1 

    Type-I interferon (IFN)-induced activation of the mammalian target of rapamycin (mTOR) signaling pathway has been implicated in translational control of mRNAs encoding interferon-stimulated genes (ISGs). However, mTOR-sensitive translatomes commonly include mRNAs with a 5’ terminal...

  • Mining small RNA structure elements in untranslated regions of human and mouse mRNAs using structure-based alignment. Khaladkar, Mugdha; Jianghui Liu; Dongrong Wen; Wang, Jason T. L.; Bin Tian // BMC Genomics;2008, Vol. 9, Special section p1 

    Background: UnTranslated Regions (UTRs) of mRNAs contain regulatory elements for various aspects of mRNA metabolism, such as mRNA localization, translation, and mRNA stability. Several RNA stem-loop structures in UTRs have been experimentally identified, including the histone 3' UTR stem-loop...

  • Structural model, physiology and regulation of Slr0006 in Synechocystis PCC 6803. Carmel, Dalton; Dahlström, Käthe; Holmström, Maija; Allahverdiyeva, Yagut; Battchikova, Natalia; Aro, Eva-Mari; Salminen, Tiina; Mulo, Paula // Archives of Microbiology;Nov2013, Vol. 195 Issue 10/11, p727 

    The slr0006 gene of Synechocystis sp. PCC 6803 is upregulated at mRNA and protein level under carbon limitation. The T(N)A motif in the upstream region of slr0006 is a binding site for transcriptional regulator NdhR, and accumulation of the Slr0006 protein in ndhR deletion mutant grown in high...

  • What's new in translation initiation?¶,The first translation determines the fate of mRNA. McKendrick, L. // Cellular & Molecular Life Sciences;Apr2003, Vol. 60 Issue 4, p639 

    The two terms 'translation' and 'protein synthesis' are interchangeable in describing the process whereby the genetic code in the form of messenger RNA (mRNA) is deciphered such that amino acids cognate with the triplet code are joined end to end to form a peptide chain. However, new data...

  • Dendritic mRNA: transport, translation and function. Bramham, Clive R.; Wells, David G. // Nature Reviews Neuroscience;Oct2007, Vol. 8 Issue 10, p776 

    Many cellular functions require the synthesis of a specific protein or functional cohort of proteins at a specific time and place in the cell. Local protein synthesis in neuronal dendrites is essential for understanding how neural activity patterns are transduced into persistent changes in...

  • Translational Profiling of Clock Cells Reveals Circadianly Synchronized Protein Synthesis. Huang, Yanmei; Ainsley, Joshua A.; Reijmers, Leon G.; Jackson, F. Rob // PLoS Biology;Nov2013, Vol. 11 Issue 11, p1 

    : This study describes, for the first time, the rhythmic translational program within circadian clock cells. The results indicate that most clock cell mRNAs are translated at low-energy times of either mid-day or mid-night, and also that related cellular functions are coordinately regulated by...

  • Translation regulation in sleep. Seibt, Julie; Frank, Marcos G. // Communicative & Integrative Biology;Sep2012, Vol. 5 Issue 5, Special section p1 

    The article discusses a study on the regulation of messenger ribonucleid acid (mRNA) translation in sleep. The study shows that at a functional level, protein synthesis necessary for ocular dominance plasticity consolidation occurs only during sleep. It shows that sleep differentially affects...

  • mRNA translation and protein synthesis: an analysis of different modelling methodologies and a new PBN based approach. Yun-Bo Zhao; Krishnan, J. // BMC Systems Biology;2014, Vol. 8 Issue 1, p1 

    Background mRNA translation involves simultaneous movement of multiple ribosomes on the mRNA and is also subject to regulatory mechanisms at different stages. Translation can be described by various codon-based models, including ODE, TASEP, and Petri net models. Although such models have been...

  • Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype. Issaenko, O A; Bitterman, P B; Polunovsky, V A; Dahlberg, P S // Cancer Gene Therapy;Sep2012, Vol. 19 Issue 9, p609 

    Pathological post-transcriptional control of the proteome composition is a central feature of malignancy. Two steps in this pathway, eIF4F-driven cap-dependent mRNA translation and the ubiquitin-proteasome system (UPS), are deregulated in most if not all cancers. We tested a hypothesis that...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics