Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy
- A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Strautnieks, Sandra S.; Bull, Laura N.; Knisely, Alexander S.; Kocoshis, Samuel A.; Dahl, Niklas; Arnell, Henrik; Sokal, Etienne; Dahan, Karine; Childs, Sarah; Ling, Victor; Tanner, M. Stuart; Kagalwalla, Amir F.; Németh, Antal; Pawlowska, Joanna; Baker, Alastair; Mieli-Vergani, Giorgina; Freimer, Nelson B.; Gardiner, R. Mark; Thompson, Richard J. // Nature Genetics;Nov98, Vol. 20 Issue 3, p233
The progressive familial intrahepatic cholestases (PFIC) are a group of inherited disorders with severe cholestatic liver disease from early infancy. A subgroup characterized by normal serum cholesterol and Î³-glutamyltranspeptidase (Î³GT) levels is genetically heterogeneous with loci on...
- Clinical utility gene card for: Progressive familial intrahepatic cholestasis type 2. Gonzales, Emmanuel; Spraul, Anne; Jacquemin, Emmanuel // European Journal of Human Genetics;Apr2014, Vol. 22 Issue 4, p00
The article presents a clinical utility gene card for progressive familial intrahepatic cholestasis type 2 disease. Among the information included in the gene card are the disease characteristics, test characteristics, and clinical utility. Also provided are questions including the burden of...
- An insertion mutation in ABCB4 is associated with gallbladder mucocele formation in dogs. Mealey, Katrina L.; Minch, Jonathan D.; White, Stephen N.; Snekvik, Kevin R.; Mattoon, John S. // Comparative Hepatology;2010, Vol. 9, p6
Background: ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi. In people, ABCB4 gene mutations are associated with several disease syndromes including intrahepatic cholestasis of pregnancy,...
- Life can begin at 40! // Medical Update;Apr95, Vol. 18 Issue 10, p2
Reports on ways that help women over 40 years of age to manage high-risk pregnancies. Prenatal diagnosis; Screening of maternal alpha-fetoprotein.
- Safe motherhood: New estimates show uneven progress. // Women's International Network News;Spring92, Vol. 18 Issue 2, p35
Examines the mortality of pregnant women around the world, as of the 1992 spring season. Risks associated with pregnancy and childbirth; Unevenness of number of maternal deaths in developing and industrialized countries; Deterioration of the economic and health conditions of women in...
- Literature reviews: Neonatal-perinatal medicine. Lampe, John B.; Lipsky, Caren L. // Clinical Pediatrics;Jan1995, Vol. 34 Issue 1, p61
Comments on the study `Consequences of Varicella and Herpes Zoster in Pregnancy: Prospective Study of 1,739 Cases,' by G. Enders, E. Miller, J. Cradock-Watson and colleagues published in `Lancet' magazine in 1994. Risks for pregnant women who have older children who contract varicella;...
- Pregnancy and patches. // Pediatrics for Parents;1992, Vol. 13 Issue 10, p1
Takes a look at the nicotine patches that have helped many smokers quit. Any damage caused to developing fetuses; Are patches better than smoking; Pure nicotine; Less toxins; If its made easy, will the women quit; From `Archives of Internal Medicine,' 4/91; Details.
- Foregut duplication cyst: A report of a case. Laraja, Raymond D.; Rothenberg, Robert E. // American Surgeon;Sep1995, Vol. 61 Issue 9, p840
Presents a case study of a pregnant woman with cystic tissues in her abdomen. Factors contributing to malformations during the early embryonal stage of foregut development; Condition of the pregnant woman; Success of the surgery which removed the cyst in the woman.
- Pregnancy and malaria. Brabin, Bernard J. // World Health;Sep/Oct95 Supplement, Vol. 48 Issue 5, p33
Focuses on the health risk posed by the occurrence of malaria during pregnancy in tropical countries. Vulnerability of women in their first two pregnancies; Increase in the risk of complications in young girls; Retardation of fetal growth; Importance of protecting pregnant women from malaria.