Association between rs1264457 A/G polymorphism of HLA-E gene and recurrent pregnancy loss

Zarezade Z.; Ashrafzadeh Mehrjardi H. R.; Zaimy M. A.; Ghasemi N.
April 2015
Iranian Journal of Reproductive Medicine;Apr2015 Supplement, p72
Academic Journal
Introduction: Recurrent pregnancy loss (RPL) is defined as two or more consecutive miscarriages before twentieth week of pregnancy. The cause of 50% recurrent miscarriages is unexplained. The goal of this research was to investigate the association between RPL and rsl264457 A/G polymorphism of HLA-E gene. Materials and Methods: In this case-control study we used Polymerase Chain Reaction Restriction Fragment Length Polymorphism (RFLP-PCR) to determine frequency of this polymorphism in 105 women with RPL in comparison with 109 healthy controls. The collected data were analyzed by the statistical package for the social sciences software (SPSS) and the chisquare test. Results: The finding showed clear correlation between this polymorphism and RPL. The results will be presented in the congress. Conclusion: If distinctive data increase frequency of this polymorphism in RPL, it can exponent influence of this polymorphism in generating RPL. We hope result of this investigation to be useful for finding some causes of unexplained recurrent pregnancy loss.


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