Effect of adding human chorionic gonadotropin to frozen thawed embryo transfer cycles with history of thin endometrium

Davar R.; Farid Mojtahedi M.; Miraj S.
April 2015
Iranian Journal of Reproductive Medicine;Apr2015 Supplement, p63
Academic Journal
Introduction: Embryo implantation process is a complex phenomenon and depends on fetal and maternal factors interaction. Endometrial thickness is needed for successful implantation. Increasing endometrial thickness, raise the chance of clinical pregnancy. The triple line pattern, with thickening more than 7mm, is indicating the greater chance of successful implantation. We designed this study to assess adding HCG to the conventional protocol in endometrial preparation in women with thin endometrium and history oflVF-ET failure. Materials and Methods: This non-randomized clinical trial study (quasi experimental design) was performed in Yazd Research and Clinical Center for Infertility on 28 patients. Participants were women who candidate for frozen thawed embryo transfer and had 2 previous failed ET cycle because of thin endometrium. All patients received 8 mg estradiol valterate on second day of menstrual cycle and continued during the study. HCG was administrated (150 IU, IM) from 8th days of cycle. In 12th-13th day Trans-vaginal sonography was done, when endometrial thickness reached at least 7mm, HCG was discontinued and frozen thawed embryo transfer was done. Results: Totally 28 patients were included. The mean age of participants was 30.39±4.7 years. The mean of endometrial thickness before and after HCG were 5.07±0.43 and 7.85±0.52 mm which were significantly different (p=0.00). After HCG administration 100% patient's endometrial thickness reached more than 7mm. The frequency of 20% improvement after HCG was 89.3% (25 patients). Also there were 5 (17.8%) clinical and chemical pregnant women after HCG. Conclusion: Our study findings suggest that adding HCG to the conventional preparation method is an effective protocol and significantly improved endometrial thickness and pregnancy outcomes in women with previous embryo transfer failure because of thin endometrium.


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