TITLE

Depression as a predictor of postoperative functional performance status (PFPS) and treatment adherence in head and neck cancer patients: a prospective study

AUTHOR(S)
Barber, Brittany; Dergousoff, Jace; Nesbitt, Margaret; Mitchell, Nicholas; Harris, Jeffrey; O'Connell, Daniel; Côté, David; Biron, Vincent; Seikaly, Hadi
PUB. DATE
September 2015
SOURCE
Journal of Otolaryngology -- Head & Neck Surgery;9/19/2015, Vol. 44 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Head and neck cancer (HNC) is a debilitating disease due in part to its effects on function, including speech, swallowing, and cosmesis. Previous studies regarding depression in HNC have focused on demographic predictors, incidence, and quality of life studies. There is, however, a paucity of studies that objectively address depressive symptoms in HNC patients and the resultant effects on post-treatment functional performance status. The aim of this study was to assess the relationship between preoperative depressive symptoms (PDS) and postoperative functional performance status (PFPS), in addition to other predictors of rehabilitation and survival. Methods: A prospective cohort study was undertaken at the University of Alberta, including all new adult HNC patients undergoing surgery as primary therapy for HNC from May 2013 to January 2014. Baseline depressive symptoms were measured on the Quick Inventory of Depressive Symptoms (QIDS) questionnaire 2 weeks preoperatively and PFPS was assessed 12 months postoperatively on the Functional Assessment of Cancer Therapy-Head & Neck (FACT-HN) scale. Secondary outcomes included completion of adjuvant therapy, narcotic dependence, return to detrimental habits, loss of follow-up, and length of hospital stay (LOHS). Differences between the Normal-Mild and Moderate-Severe QIDS groups were assessed using Mann--Whitney and Fischer Exact statistical analyses. Results: Seventy-one patients were included in the study. Mild and Moderate-Severe PDS were 35.2 % and 18.3 %, respectively. Significantly lower FACT-HN scores were noted in the Moderate-Severe group at 12 months (p = 0.03). The risk ratio (RR) for FACT-HN score < 50 % at 12 months in the Moderate-Severe group was 5.66. In addition, significantly lower completion of adjuvant treatment (p = 0.03), significantly higher incidence of narcotic dependence (p = 0.004), and significantly higher LOHS (24 days vs. 18 days; p = 0.02) was observed in the Moderate-Severe group. There was no significant difference in loss of follow-up between the 2 groups (p = 0.64). Conclusions: The incidence and severity of PDS in HNC patients treated with surgery is high (53.5 %). Patients with Moderate-Severe PDS have significantly decreased PFPS, increased narcotic use, decreased completion of adjuvant therapy, and a longer LOHS. HNC patients should be monitored closely for depressive symptoms.
ACCESSION #
109545034

 

Related Articles

  • Physical Therapists as Primary Practitioners in the Emergency Department: Six-Month Prospective Practice Analysis. de Gruchy, Adam; Granger, Catherine; Gorelik, Alexandra // Physical Therapy;Sep2015, Vol. 95 Issue 9, p1207 

    Background. Increasing pressure on the emergency department (ED) throughout the world has meant the introduction of innovative ways of working. One such innovation is the advanced practice physical therapist (APP) acting as a primary contact practitioner. There has been little research into the...

  • Pirfenidone treatment in idiopathic pulmonary fibrosis: A Saudi experience. Alhamad, Esam H. // Annals of Thoracic Medicine;Jan-Mar2015, Vol. 10 Issue 1, p38 

    BACKGROUND: Recent trials involving pirfenidone suggest a beneficial effect in the treatment of idiopathic pulmonary fibrosis (IPF). OBJECTIVE: To report on the efficacy and safety of pirfenidone in the treatment of patients with IPF, at a tertiary care hospital in Saudi Arabia. METHODS: The...

  • Sensory Processing Patterns in Children Born Very Preterm. Crozier, Stephanie C.; Goodson, Jennifer Z.; Mackay, Margot L.; Synnes, Anne R.; Grunau, Ruth E.; Miller, Steven P.; Zwicker, Jill G. // American Journal of Occupational Therapy;Jan/Feb2016, Vol. 70 Issue 1, p1 

    OBJECTIVE. We describe the prevalence and type of sensory processing differences in children born very preterm and determine associations with neonatal risk factors. METHOD. We assessed sensory processing patterns using the Short Sensory Profile in a retrospective cohort of 160 children age 4 yr...

  • Alteco endotoxin hemoadsorption in Gram-negative septic shock patients. Hoi Ping Shum; Yuk Wah Leung; Sin Man Lam; King Chung Chan; Wing Wa Yan // Indian Journal of Critical Care Medicine;Dec2014, Vol. 18 Issue 12, p783 

    Background and Aims: Severe sepsis and septic shock are common causes of mortality and morbidity in an intensive care unit setting. Endotoxin, derived from the outer membranes of Gram-negative bacteria, is considered a major factor in the pathogenesis of sepsis. This study investigated the...

  • Results of a prospective multicenter neuroendocrine tumor registry reporting on clinicopathologic characteristics of Greek patients. Nikou, George C.; Pazaitou-Panayiotou, Kalliopi; Dimitroulopoulos, Dimitrios; Alexandrakis, Georgios; Papakostas, Pavlos; Vaslamatzis, Michalis; Kaldrymidis, Philippos; Markussis, Vyron; Koumarianou, Anna // BMC Endocrine Disorders;2/12/2016, Vol. 16, p1 

    Background: The rare incidence of neuroendocrine neoplasms (NENs) has contributed to a paucity of large epidemiologic studies of patients with this condition. We investigated the occurrence and clinicopathologic features of NENs in Greece. Methods: Between October 2010 and November 2012 we...

  • Braces versus Invisalign®: gingival parameters and patients' satisfaction during treatment: a cross-sectional study. Azaripour, A.; Weusmann, J.; Mahmoodi, B.; Peppas, D.; Gerhold-Ay, A.; Van Noorden, C. J. F.; Willershausen, B. // BMC Oral Health;2015, Vol. 15 Issue 1, p1 

    Background: Fixed orthodontic appliances (FOA) temporarily interfere with periodontal health of patients, as the appliance complicates oral hygiene. The use of aligners in orthodontic therapy increased strongly during the last decade. In the literature, the reports about effects of aligner...

  • Depression and anxiety as potential correlates of post‑transplantation renal function and quality of life. Jana, A. K.; Sircar, D.; Waikhom, R.; Praharaj, S. K.; Pandey, R.; RayChaudhury, A.; Dasgupta, S. // Indian Journal of Nephrology;Sep/Oct2014, Vol. 24 Issue 5, p286 

    The objective of this study was to determine anxiety and depression and its relationship with quality of life (QOL) in renal transplant (RT) recipients. A total of 105 consecutive patients were assessed cross‑sectionally at least 3 months after RT. Hospital Anxiety and Depression Scale...

  • Painful Temporomandibular Disorders Are Common in Patients with Postural Orthostatic Tachycardia Syndrome and Impact Significantly upon Quality of Life. Durham, Justin; McDonald, Claire; Hutchinson, Luke; Newton, Julia L. // Journal of Oral & Facial Pain & Headache;2015, Vol. 29 Issue 2, p152 

    Aims: To explore the point prevalence of painful temporomandibular disorders (TMD) in a well-characterized clinical cohort of postural orthostatic tachycardia syndrome (PoTS) sufferers and to understand the functional and physiologic impact of this comorbidity on the patient. Methods: Patients...

  • Gender-attributable differences in outcome of ankylosing spondylitis: long-term results from the Outcome in Ankylosing Spondylitis International Study. Webers, Casper; Essers, Ivette; Ramiro, Sofia; Stolwijk, Carmen; Landewé, Robert; van der Heijde, Désirée; van den Bosch, Filip; Dougados, Maxime; van Tubergen, Astrid // Rheumatology;Mar2016, Vol. 55 Issue 3, p419 

    Objectives. To investigate gender-attributable differences regarding clinical outcome [disease activity, physical function and quality of life (QoL)] and radiographic damage in patients with AS over time. Methods. Data from the Outcome in AS International Study were used. Disease activity was...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics