TITLE

Synthesis and Charactersiation of Chitosan conjugate; Design and Evaluation of Membrane Moderated Type Transdermal Drug Delivery System

AUTHOR(S)
SATHEESHABABU, B. K.; SHRUTHINAG, R.
PUB. DATE
July 2015
SOURCE
Indian Journal of Pharmaceutical Sciences;Jul/Aug2015, Vol. 77 Issue 4, p405
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The purpose of the present research investigation was to synthesis, characterisation of chitosan conjugates and its effect on drug permeation from transdermal rate controlling membrane. Chitosan conjugate was synthesised by conjugation with thioglycolic acid. The prepared chitosan conjugate was characterised by determining the charring point, Fourier transmission-infrared and differential scanning calorimetric analysis. The rate controlling membranes were prepared by various proportions of chitosan and chitosan conjugate, to moderate drug permeation through rate controlling membrane. The membrane moderated transdermal system consists of reservoir to hold the drug gel was prepared by 20% w/v ethylcellulose with a cavity in its center. An impermeable backing layer was prepared by 2% w/v ethylcellulose. Gel consists of carvedilol was prepared by sodium alginate and sodium carboxymethylcellulose in ethanol:water solvent system The rate controlling membranes prepared were evaluated by various parameters like thickness, folding endurance, swelling index, moisture content, moisture uptake, water vapor transmission rate, tensile strength test, measurement of gel strength, in vitro permeation study, ex vivo permeation study, compatibility study using differential scanning calorimetry and stability studies. All physical parameters evident that prepared membranes have good folding endurance and sufficient tensile strength. As the proportion of chitosan conjugate increases in membrane swelling index, moisture content, moisture uptake and permeability coefficient increases. The gel strength of chitosan conjugate was considerable less compared with chitosan.
ACCESSION #
109374039

 

Related Articles

  • Preparation of CMC/HEC Crosslinked Hydrogels for Drug Delivery. Xiaoxiang Wen; Dengshan Bao; Mingjie Chen; Aiping Zhang; Chuanfu Liu; Runcang Sun // BioResources;2015, Vol. 10 Issue 4, p8339 

    A novel crosslinked hydrogel was prepared from sodium carboxymethyl cellulose (CMC) and hydroxyethyl cellulose (HEC) using ammonium persulfate as an initiator and methylenebisacrylamide as a crosslinker for drug delivery. The chemical structure of the copolymer was characterized by Fourier...

  • Formulation and Evaluation of Cefixime Trihydrate Matrix Tablets Using HPMC, Sodium CMC, Ethyl Cellulose. SIRISOLLA, JANAKIDEVI; RAMANAMURTHY, K. V. // Indian Journal of Pharmaceutical Sciences;May/Jun2015, Vol. 77 Issue 3, p321 

    The objective of the present work is to design sustained release matrix tablets of cefixime trihydrate by incorporating drug in a matrix made up of release retardant polymers, which prolong drug release leading to minimization of the peak and valley effect in the plasma and provide patient...

  • FORMULATION OF BIOADHESIVE MATRIX TABLETS WITH DIFFERENT CONCENTRATIONS OF CARBOPOL AND SODIUM CARBOXYMETHYL CELLULOSE USING AN EXPERIMENTAL DESIGN. Pereanu, Adela Elena; Tomuţă, Ioan; Dinte, Elena; Leucuţa, Sorin E. // Clujul Medical;Sep2012, Vol. 85 Issue 3, p369 

    Aims. The aim of this work was to study the effect of different combinations of three widely used bioadhesive polymers on the properies of bioadhesive matrix tablets with famotidine. Materials and methods. To perform the study an experimental design with two factors and three levels was used....

  • TRANSDERMAL DELIVERY OF SOTALOL: IN VITRO AND EX VIVO STUDIES. INAL, Özge; ALGIN YAPAR, Evren; BAYKARA, Tamer // Turkish Journal of Pharmaceutical Sciences;2014, Vol. 11 Issue 3, p255 

    The purpose of this study is to investigate in vitro release and ex vivo transdermal penetration of sotalol from monolithic films prepared by Eudragit E100 (E100) combined with Eudragit RS100 (RS100) or ethyl cellulose (EC) prepared onto a PVA backing membrane by solvent casting method. Film...

  • Optimization of In-vitro Permeation Pattern of Ketorolac Tromethamine Transdermal Patches. Kumar De, Pintu; Mallick, Subrata; Mukherjee, Biswajit; Sengupta, Sagar; Pattnaik, Satyanarayan; Chakraborty, Subrata // Iranian Journal of Pharmaceutical Research;Jun2011, Vol. 10 Issue 2, p193 

    The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different...

  • DEVELOPMENT OF ZOLMITRIPTAN GEL FOR NASAL ADMINISTRATION. KOLSURE, PRAMOD K.; RAJKAPOOR, B. // Asian Journal of Pharmaceutical & Clinical Research;Jul2012, Vol. 5 Issue 3, p88 

    Development of thermoreversible zolmitriptan nasal gel were aimed to improve absorption and patient compliance. In the present research work, mixture of pluronic F-127 (Poloxamer 407) and pluronic F-68 (Poloxamer 188) were used to confer temperature - sensitive gelation property. To modulate the...

  • Swelling/Floating Capability and Drug Release Characterizations of Gastroretentive Drug Delivery System Based on a Combination of Hydroxyethyl Cellulose and Sodium Carboxymethyl Cellulose. Chen, Ying-Chen; Ho, Hsiu-O; Liu, Der-Zen; Siow, Wen-Shian; Sheu, Ming-Thau // PLoS ONE;Jan2015, Vol. 10 Issue 1, p1 

    The aim of this study was to characterize the swelling and floating behaviors of gastroretentive drug delivery system (GRDDS) composed of hydroxyethyl cellulose (HEC) and sodium carboxymethyl cellulose (NaCMC) and to optimize HEC/NaCMC GRDDS to incorporate three model drugs with different...

  • Review of Patents on Microneedle Applicators. Singh, Thakur R. R.; Dunne, Nicholas J.; Cunningham, Eoin; Donnelly, Ryan F. // Recent Patents on Drug Delivery & Formulation;Jan2011, Vol. 5 Issue 1, p11 

    Transdermal drug delivery offers certain advantages over conventional oral or parenteral administration. However, transdermal delivery is not available to many promising therapeutic agents, especially high molecular weight hydrophilic compounds. This is due to the excellent barrier property of...

  • PREPARATION OF MONOLITHIC TRANSDERMAL DRUG DELIVERY SYSTEM FOR ARTHRITIS TREATMENT AND EFFECT OF PERMEATION ENHANCERS ON RELEASE KINETICS. Kumar, Putta Rajesh; Tatavarthi, Rajesh; Gouda, M. Mallikarjuna; Shyale, Somashekar; Kuma, S. M. Shanta // International Journal of Pharmaceutical Sciences Review & Resear;Jan/Feb2011, Vol. 6 Issue 2, p56 

    Monolithic transdermal films of Nimesulide (NIM) were prepared to avoid hepatic first pass effect by using hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC) alone and in combination with co-polymer poly vinyl pyrollidone (PVP) by solvent casting method. Dibutyl phthalate (DBP) was...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics