TITLE

Mast Cell and Autoimmune Diseases

AUTHOR(S)
Xu, Yunzhi; Chen, Guangjie
PUB. DATE
April 2015
SOURCE
Mediators of Inflammation;4/5/2015, Vol. 2015, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Mast cells are important in innate immune system. They have been appreciated as potent contributors to allergic reaction. However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis. Here we review the current stage of knowledge about mast cells in autoimmune diseases.
ACCESSION #
109224150

 

Related Articles

  • Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Costanza, Massimo; Colombo, Mario P.; Pedotti, Rosetta // International Journal of Molecular Sciences;Nov2012, Vol. 13 Issue 11, p15107 

    Mast cells (MCs) are best known as key immune players in immunoglobulin E (IgE)-dependent allergic reactions. In recent years, several lines of evidence have suggested that MCs might play an important role in several pathological conditions, including autoimmune disorders such as multiple...

  • Mast Cells and the Adaptive Immune Response. Blayne Sayed; Alison Christy // Journal of Clinical Immunology;Nov2008, Vol. 28 Issue 6, p671 

    Abstract Background  The idea that the innate and adaptive immune systems are not separate entities is no longer new. In fact, it is surprising that this paradigm was accepted without question for so long. Many innate cells express cell surface molecules and soluble mediators...

  • Novel Mast Cell Lines with Enhanced Proliferative and Degranulative Abilities Established from Temperature-Sensitive SV40 Large T Antigen Transgenic Mice. Kanehira, Masahiko; Kaifu, Tomonori; Maya, Kozue; Kaji, Mitsuji; Nakamura, Akira; Obinata, Masuo; Takai, Toshiyuki // Journal of Biochemistry;Aug2006, Vol. 140 Issue 2, p211 

    Mast cells (MCs) play crucial roles in innate immunity to parasitic and bacterial infections as well as in hypersensitivity, such as the induction and exacerbation of allergy and autoimmune diseases. The regulatory mechanisms for MC development and effector functions are of great interest for...

  • Researchers Identify Gene Involved in Autoimmune Disease.  // Ascribe Newswire: Medicine;7/25/2002, p2 

    Researchers have identified a gene that appears to be a critical factor in autoimmune disease, according to a study. The research might provide a unique view at the molecular defects underlying autoimmune disease. Using molecular techniques to study the genetic material from autoimmune...

  • IL-17 producing T cells in mouse models of multiple sclerosis and rheumatoid arthritis. Pöllinger, Bernadette // Journal of Molecular Medicine;Jun2012, Vol. 90 Issue 6, p613 

    Multiple Sclerosis (MS) and Rheumatoid Arthritis (RA) are amongst the most common autoimmune diseases in the northern hemisphere. There is mounting evidence that in both afflictions, not only environmental and genetic factors influence disease, but cellular components such as autoreactive T...

  • CD226 Gly307Ser association with multiple autoimmune diseases. Hafler, J. P.; Maier, L. M.; Cooper, J. D.; Plagnol, V.; Hinks, A.; Simmonds, M. J.; Stevens, H. E.; Walker, N. M.; Healy, B.; Howson, J. M. M.; Maisuria, M.; Duley, S.; Coleman, G.; Gough, S. C. L.; Worthington, J.; Kuchroo, V. K.; Wicker, L. S.; Todd, J. A. // Genes & Immunity;Jan2009, Vol. 10 Issue 1, p5 

    Genome-wide association studies provide insight into multigenic diseases through the identification of susceptibility genes and etiological pathways. In addition, the identification of shared variants among autoimmune disorders provides insight into common disease pathways. We previously...

  • In This Issue.  // Clinical Pharmacology & Therapeutics;Apr2012, Vol. 91 Issue 4, p559 

    The article presents the highlights of the journal of "Clinical Pharmacology & Therapeutics," Volume 9, issue 4 in April 2012. It includes articles on the advances in the treatment of rheumatoid arthritis, advancing imaging to develop a treatment for multiple sclerosis (MS), and prediction of...

  • Mouse Models of Autoimmune Diseases. Marques, Andreia; Müller, Susen // Current Drug Discovery Technologies;Dec2009, Vol. 6 Issue 4, p262 

    Abstract: Significant progress has been made in past decades in our understanding of the basic mechanisms underlying autoimmune diseases. Nevertheless, many questions remain unanswered, in particular regarding the mechanisms at very early stages of these diseases. Reliable animal models are of...

  • Endothelial Chemokines in Autoimmune Disease. Christopherson II, Kent W.; Hromas, Robert A. // Current Pharmaceutical Design;Jan2004, Vol. 10 Issue 2, p145 

    Compelling evidence now exists supporting the involvement of chemokines in the pathogenesis of autoimmune diseases. Examples of chemokines and chemokine receptors being involved in mediating autoimmune disease exist for rheumatoid arthritis, multiple sclerosis, allograft rejection, systemic...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics