TITLE

Effects of Surface-Deacetylated Chitin Nanofibers in an Experimental Model of Hypercholesterolemia

AUTHOR(S)
Kazuo Azuma; Tomone Nagae; Takeshi Nagai; Hironori Izawa; Minoru Morimoto; Yusuke Murahata; Tomohiro Osaki; Takeshi Tsuka; Tomohiro Imagawa; Norihiko Ito; Yoshiharu Okamoto; Hiroyuki Saimoto; Shinsuke Ifuku
PUB. DATE
August 2015
SOURCE
International Journal of Molecular Sciences;Aug2015, Vol. 16 Issue 8, p17445
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study evaluated the effects of oral administration of surface-deacetylated chitin nanofibers (SDACNFs) on hypercholesterolemia using an experimental model. All rats were fed a high cholesterol diet with 1% w/w cholesterol and 0.5% w/w cholic acid for 28 days. Rats were divided equally into four groups: the control group was administered 0.05% acetic acid dissolved in tap water, and the SDACNF, chitosan (CS), and cellulose nanofiber (CLNF) groups were administered 0.1% CNF, CS, or CLNF dissolved in the tap water, respectively, during the experimental period. Changes in body weight, intake of food and water, and organ weight were measured. Serum blood chemistry and histopathological examination of the liver were performed. Administration of SDACNF did not affect body weight change, food and water intake, or organ weights. Administration of SDACNF and CS decreased the diet-induced increase in serum total cholesterol, chylomicron, very-low-density lipoprotein, and phospholipid levels on day 14. Moreover, oral administration of SDACNFs suppressed the increase of alanine transaminase levels on day 29 and suppressed vacuolar degeneration and accumulation of lipid droplets in liver tissue. These data indicate that SDACNF has potential as a functional food for patients with hypercholesterolemia.
ACCESSION #
109123133

 

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