TITLE

Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery

AUTHOR(S)
Knežević, Nikola Ž.; Milenković, Sanja; Jović, Danica; Lazarevic, Slavica; Mrdjanović, Jasminka; Djordjevic, Aleksandar
PUB. DATE
July 2015
SOURCE
Advances in Materials Science & Engineering;7/21/2015, Vol. 2015, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.
ACCESSION #
109050395

 

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