TITLE

Prospective study of the safety and efficacy of a pancreatic cancer stem cell vaccine

AUTHOR(S)
Lin, Mao; Yuan, Yuan-Ying; Liu, Shu-Peng; Shi, Juan-Juan; Long, Xin-An; Niu, Li-Zhi; Chen, Ji-Bing; Li, Qiao; Xu, Ke-Cheng
PUB. DATE
October 2015
SOURCE
Journal of Cancer Research & Clinical Oncology;Oct2015, Vol. 141 Issue 10, p1827
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: In this trial, we isolated and cultured pancreatic cancer stem cells (CSCs) to produce a vaccine and prospectively evaluated its safety and efficacy in low-, medium-, and high-dose groups. Material and methods: Between February and October 2014, we enrolled 90 patients who met the enrollment criteria and assigned them to three groups ( n = 30). CSC-specific and CSC-non-specific immunity pre- and post-vaccination were compared by Dunnett's multiple comparison test (one-way ANOVA). The data are presented as the mean±standard deviation. Local and systemic adverse events were recorded in the nursing records and compared using the Chi-square test. All statistical analyses were conducted using GraphPad software (GraphPad, San Diego, CA, USA). Results: Throughout the trial, an injection site reaction was the most common reaction (54 %), and fever was least common (9 %). The incidence of these side effects did not vary among the three groups. When the pre- and post-vaccination immunity was compared, we found that both CSC-nonspecific and CSC-specific responses were significantly increased in the high-dose group. Conclusion: This study is the first clinical trial of a pancreatic CSC vaccine and preliminarily proves its safety and efficacy.
ACCESSION #
109016873

 

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