Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer's disease

Agarwal, Rachna; Talwar, Puneet; Kushwaha, Suman S.; Tripathi, Chandra Bhushan; Kukreti, Ritushree
July 2015
Annals of Indian Academy of Neurology;Jul-Sep2015, Vol. 18 Issue 3, p320
Academic Journal
Background: Leptin, a 16 kDa peptide hormone synthesized and secreted specifically from white adipose cells protects neurons against amyloid β-induced toxicity, by increasing Apolipoprotein E (APO E)-dependent uptake of β amyloid into the cells, thereby, protect individuals from developing Alzheimer's disease (AD). The APO E e4 allele is a known genetic risk factor for AD by accelerating onset. It is estimated that the lifetime risk of developing AD increases to 29% for carriers with one ε4 allele and 9% for those with no ε4 allele. Objectives: To determine the levels of serum leptin, cholesterol, low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) in the diagnosed cases of AD and the association of them with cognitive decline and Apolipoprotein E (APO E) genotypes in AD. Materials and Methods: Serum levels of serum leptin, cholesterol, LDL-C, and HDL-C along with APO E polymorphism were studied in 39 subjects with probable AD and 42 cognitive normal individuals. Results: AD group showed significantly lower levels of leptin (P = 0.00) as compared to control group. However, there was no significant difference in cholesterol, triglycerides, LDL-C, and HDL-C levels in AD and control groups. The frequency of ε4 allele in AD (38.5%) was found to be significantly higher than in control (10.3%). ε3 allele was more frequent than ε4 allele in AD and control group.


Related Articles

  • Correlation between oxidized-LDL and interleukin-6 in type 2 diabetic patients. Ghadiri-Anari, Akram; Behjati, Javad; Esteghamati, Alireza; Esfahanian, Fatemeh; Khazaiipoor, Zahra; Nakhjavani, Manouchehr // Iranian Journal of Diabetes & Lipid Disorders;2011, Vol. 10, p1 

    Background: Studies have suggested that oxidative stress is a common pathway of different leading mechanisms to diabetes complications. Oxidative stress play a crucial role in atherogenesis and cause oxidation of low density lipoprotein. Evidence has been shown that oxidized LDL in diabetic...

  • The association of ghrelin -501A/C polymorphism with ghrelin and leptin levels in non-obese Saudi Population with type 2 diabetes mellitus. Ali, Tarek Mohamed; Khalifa, Amany Salah; Ali, Mohamed Noureldin H. // National Journal of Physiology, Pharmacy & Pharmacology;2015, Vol. 5 Issue 3, p243 

    Background: Saudi Arabia is one of the three of the world's top 10 countries with the highest prevalence of diabetes mellitus. Ghrelin is a gut-brain endogenous peptide, and the genetic variations within the gene have been associated with the risk of developing type 2 diabetes mellitus (T2DM)....

  • The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults. Vimaleswaran, Karani Santhanakrishnan; Minihane, Anne M.; Yue Li; Gill, Rosalyn; Lovegrove, Julie A.; Williams, Christine M.; Jackson, Kim G. // Nutrition & Metabolism;2015, Vol. 12 Issue 1, p1 

    Background: Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del)...

  • Study on Association of Peroxisome Proliferator-Activated Receptor α with C-Reactive Protein, and Additional Gene-Gene Interaction in Chinese Han. Su-Qin Zhang; Ge-Lin Li; Yu-Feng Liu; Yu-Qin Li // Archives of Iranian Medicine (AIM);Nov2015, Vol. 18 Issue 11, p765 

    Background: The aim was to examine the association between 6 single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptors a (PPAR α) poly morphisms and C-reactive protein (CRP) level, as well as additional gene-gene interaction among the 6 SNPs. Methods: A total of...

  • Association of apolipoprotein B, apolipoprotein A, and the its ratio with body fat distribution. Sadeghi, Masoumeh; Pourmoghaddas, Zahra; Hekmatnia, Ali; Sanei, Hamid; Tavakoli, Babak; Tchernof, Andre; Roohafza, Hamidreza; Sarrafzadegan, Nizal // Journal of Research in Medical Sciences;Apr2013, Vol. 18 Issue 4, p326 

    Background: To evaluate the association of apolipoprotein B (apoB), apolipoprotein A (apoA), and apoB/apoA ratio with the body fat indicators in patients with stable angina pectoris (SA). Materials and Methods: One hundred and twenty two participants aged 40-60 years old, with a mean age of 52.1...

  • Increase in soluble CD95L during subacute phases after human spinal cord injury: a potential therapeutic target. Biglari, B; Büchler, A; Swing, T; Biehl, E; Roth, H J; Bruckner, T; Schmidmaier, G; Ferbert, T; Gerner, H J; Moghaddam, A // Spinal Cord;Mar2013, Vol. 51 Issue 3, p183 

    Study design:A pilot study measuring the levels of serum-soluble CD95 ligand (CD95L) in eight spinal cord-injured patients.Objectives:To determine the soluble concentration of CD95L in spinal cord injury (SCI) patients after trauma.Methods:We collected blood samples from eight patients with...

  • Low Maternal Vitamin B12 Status Is Associated with Lower Cord Blood HDL Cholesterol in White Caucasians Living in the UK. Adaikalakoteswari, Antonysunil; Vatish, Manu; Lawson, Alexander; Wood, Catherine; Sivakumar, Kavitha; McTernan, Philip G.; Webster, Craig; Anderson, Neil; Yajnik, Chittaranjan S.; Tripathi, Gyanendra; Saravanan, Ponnusamy // Nutrients;2015, Vol. 7 Issue 4, p2401 

    Background and Aims: Studies in South Asian population show that low maternal vitamin B12 associates with insulin resistance and small for gestational age in the offspring. Low vitamin B12 status is attributed to vegetarianism in these populations. It is not known whether low B12 status is...

  • The Relationship Between Serum Lipid Profile and Selected Trace Elements for Adult Men in Mosul City. Al-sabaawy, Osama M. // Oman Medical Journal;Jul2012, Vol. 27 Issue 4, p303 

    Objectives: To evaluate the correlations of the serum concentrations of copper, zinc, and manganese with lipid profile parameters of adult men in Mosul City, Iraq. Methods: The study included 51 apparently healthy adult men as a control group aged 34-62 years (group 1), and 31 hyperlipidemic...

  • Vitamin D as a marker of cognitive decline in elderly Indian population. Vedak, Tejal Kanhaiya; Ganwir, Vaishali; Shah, Arun B.; Pinto, Charles; Lele, Vikram R.; Subramanyam, Alka; Shah, Hina; Deo, Sudha Shrikant // Annals of Indian Academy of Neurology;Jul-Sep2015, Vol. 18 Issue 3, p314 

    Objectives: Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics