TITLE

Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study

AUTHOR(S)
Miyazaki, Keiko; Jerome, Neil; Collins, David; Orton, Matthew; d'Arcy, James; Wallace, Toni; Moreno, Lucas; Pearson, Andrew; Marshall, Lynley; Carceller, Fernando; Leach, Martin; Zacharoulis, Stergios; Koh, Dow-Mu
PUB. DATE
September 2015
SOURCE
European Radiology;Sep2015, Vol. 25 Issue 9, p2641
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: The objectives are to examine the reproducibility of functional MR imaging in children with solid tumours using quantitative parameters derived from diffusion-weighted (DW-) and dynamic contrast enhanced (DCE-) MRI. Methods: Patients under 16-years-of age with confirmed diagnosis of solid tumours ( n = 17) underwent free-breathing DW-MRI and DCE-MRI on a 1.5 T system, repeated 24 hours later. DW-MRI (6 b-values, 0-1000 sec/mm) enabled monoexponential apparent diffusion coefficient estimation using all (ADC) and only ≥100 sec/mm (ADC) b-values. DCE-MRI was used to derive the transfer constant (K), the efflux constant (k), the extracellular extravascular volume (v), and the plasma fraction (v), using a study cohort arterial input function (AIF) and the extended Tofts model. Initial area under the gadolinium enhancement curve and pre-contrast T were also calculated. Percentage coefficients of variation (CV) of all parameters were calculated. Results: The most reproducible cohort parameters were ADC (CV = 3.26 %), pre-contrast T (CV = 6.21 %), and K (CV = 15.23 %). The ADC was more reproducible than ADC, especially extracranially (CV = 2.40 % vs. 2.78 %). The AIF ( n = 9) derived from this paediatric population exhibited sharper and earlier first-pass and recirculation peaks compared with the literature's adult population average. Conclusions: Free-breathing functional imaging protocols including DW-MRI and DCE-MRI are well-tolerated in children aged 6 - 15 with good to moderate measurement reproducibility. Key Points: • Diffusion MRI protocol is feasible and well-tolerated in a paediatric oncology population. • DCE-MRI for pharmacokinetic evaluation is feasible and well tolerated in a paediatric oncology population. • Paediatric arterial input function (AIF) shows systematic differences from the adult population-average AIF. • Variation of quantitative parameters from paired functional MRI measurements were within 20 %.
ACCESSION #
108790715

 

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