Liver Failure in a Child Receiving Highly Active Antiretroviral Therapy and Voriconazole

Scherpbier, Henriette J.; Hilhorst, Michaela I.; Kuijpers, Taco W.
September 2003
Clinical Infectious Diseases;9/15/2003, Vol. 37 Issue 6, p828
Academic Journal
Presents a case of liver failure in a child receiving highly active antiretroviral therapy and voriconazole. Increase of liver enzyme levels one day after the start of voriconazole therapy; Metabolic impact of the protease inhibitors as a substrate of the cytochrome p450 isoenzymes; Exhibition of nonlinear pharmacokinetics of voriconazole.


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