Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells
- Crypt region localization of intestinal stem cells in adults. Freeman, Hugh James; Cario, Elke // World Journal of Gastroenterology;12/21/2008, Vol. 14 Issue 47, p7160
The intestinal epithelial lining plays a central role in the digestion and absorption of nutrients, but exists in a harsh luminal environment that necessitates continual renewal. This renewal process involves epithelial cell proliferation in the crypt base and later cell migration from the crypt...
- The Food-Associated Ribotoxin Deoxynivalenol Modulates Inducible NO Synthase in Human Intestinal Cell Model. Graziani, Fabien; Pujol, Ange; Nicoletti, Cendrine; Pinton, Philippe; Armand, Loriane; Di Pasquale, Eric; Oswald, Isabelle P.; Perrier, Josette; Maresca, Marc // Toxicological Sciences;Jun2015, Vol. 145 Issue 2, p372
The intestinal epithelium possesses active immune functions including the production of proinflammatory cytokines and antimicrobial molecules such as nitric oxide (NO). As observed with immune cells, the production of NO by the intestinal epithelium is mainly due to the expression of the...
- Differences in the modulating potential of advanced glycation end product (AGE) peptides versus AGE proteins. Deuther-Conrad, Winnie; Franke, Sybille; Sommer, Manfred; Henle, Thomas; Stein, GÜnter // Kidney International Supplement;Feb2001, Issue 78, pS-63
Investigates the differences in the modulating potential of advanced glycation and product peptides (AGE) peptides and proteins. Effects of the accumulation of compound on degeneration of tubular epithelial cells; Parameters of cellular damage and growth behavior; Correlation between decreased...
- Telomerase linked with cancer risk? Bouchie, Aaron J. // Nature Biotechnology;Aug2000, Vol. 18 Issue 8, p813
Reports that the use of telomerase to induce proliferation in cultured cells for use in therapies may be associated with malignant changes. Effect of human telomerase reverse transcriptase on human mammary epithelial cells.
- Morphogenesis: Getting cells moving. Toit, Andrea Du // Nature Reviews Molecular Cell Biology;Jan2015, Vol. 16 Issue 1, p2
The article reports on a study which describes the transformations of epithelial tubes during mid-embryogenesis in the absence of cell proliferation.
- Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2. Kennedy, D. J.; Raldua, D.; Thwaites, D. T. // Cellular & Molecular Life Sciences;Jul2005, Vol. 62 Issue 14, p1621
Selective pharmacological Na+/H+ exchange (NHE) inhibitors were used to identify functional NHE isoforms in human small intestinal enterocytes (Caco-2) and to distinguish between direct and indirect effects on transport via the intestinal di/tripeptide transporter hPepT1. The relative potencies...
- Mechanisms of the Regulation of the Intestinal Na+/H+ Exchanger NHE3. Peijian He; C. Chris Yun // Journal of Biomedicine & Biotechnology;2010, p1
Amajor of Na+ absorptive process in the proximal part of intestine and kidney is electroneutral exchange of Na+ and H+ by Na+/H+ exchanger type 3 (NHE3). During the past decade, significant advance has been achieved in the mechanisms of NHE3 regulation. A bulk of the current knowledge on Na+/H+...
- Reduced proliferation and cell adhesion in endometriosis. Scotti, S. // MHR: Basic Science of Reproductive Medicine;Jul2000, Vol. 6 Issue 7
Examines the reduced proliferation and cell adhesion in endometriosis. Proliferation activity in uterine epithelium within the ectopic lesions; Expression of the adhesion complex E-cadherin; Invasive proliferation of epithelial cells of endometriotic lesions.
- Evidence for altered vascular responses to exogenous endothelin-1 in patients with advanced cirrhosis with restoration of the normal vasoconstrictor response following successful liver transplantation. Vaughan R B; Angus P W; Chin-Dusting J P F // Gut;Oct2003, Vol. 52 Issue 10, p1505
BACKGROUND: and aims: There is evidence that dampened responses to endogenous vasoconstrictors contribute to the hyperdynamic circulation that is characteristic of advanced cirrhosis. The aim of this study was to determine whether there is an altered vascular responsiveness to the endothelium...