TITLE

Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001

AUTHOR(S)
Hildebrand H; Finkel Y; Grahnquist L; Lindholm J; Ekbom A; Askling J
PUB. DATE
October 2003
SOURCE
Gut;Oct2003, Vol. 52 Issue 10, p1432
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
BACKGROUND: An increased incidence of paediatric Crohn's disease was reported recently by our group. AIMS: To assess the incidence and characteristics of inflammatory bowel disease (IBD) in northern Stockholm between 1990 and 2001. METHODS: All records of individuals 0-15 years of age with suspected IBD in the population based catchment area of 180 000 individuals were scrutinised using defined diagnostic criteria. Patient files were searched for relatives with IBD, and for concomitant autoimmune diseases. RESULTS: A total of 152 children were diagnosed with IBD, corresponding to an overall incidence (per 100 000) of IBD of 7.4. The incidence of Crohn's disease (CD) was 4.9, ulcerative colitis (UC) 2.2, and indeterminate colitis 0.2. Between 1990 and 2001, there was a marked increase in the incidence of CD while the incidence of UC was almost unchanged, leading to a net increase in the overall occurrence of IBD. There was a male dominance of CD. Fourteen per cent and 11% of patients with CD and UC, respectively, had a first or second degree relative with IBD. Eighteen per cent and 10% of patients with CD and UC, respectively, had a concomitant autoimmune disease. Ten patients with CD (10%) underwent surgery. CONCLUSIONS: The incidence of CD has increased in northern Stockholm. The current incidence is higher than that reported from other areas. Our results suggest a shift in presentation and diagnosis from UC towards CD, but also a net increase in IBD. Concomitant autoimmune disorders and family history are common in paediatric IBD.
ACCESSION #
10854354

 

Related Articles

  • Macrophage-Derived IL-18 Targeting for the Treatment of Crohn's Disease. T. Kanai; K. Uraushihara; T. Totsuka; A. Okazawa; T. Hibi; S. Oshima; T. Miyata; T. Nakamura; M. Watanabe // Current Drug Targets - Inflammation & Allergy;Jun2003, Vol. 2 Issue 2, p131 

    Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-a (TNF-a), macrophage infiltrating...

  • Crohn's disease: ethnic variation in CARD15 genotypes. Marsh, S.; McLeod, H.L. // Gut;May2003, Vol. 52 Issue 5, p770 

    Examines the variability in the incidence of Crohn's disease between different world populations. Role of the CARD15 gene in the ethnic variation of the incidence of the disease.

  • Crohn's disease, Crohn disease.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p546 

    An encyclopedia entry for "Crohn's disease" and "Crohn disease," which refer to an inflammatory bowel disease, is presented.

  • Crohn's disease.  // GP: General Practitioner;3/18/2002, p66 

    Focuses on crohn's disease, an inflammatory disorder affecting any part of Gl tract. Clinical features of the disease; Diagnosis of the disease; Pathophysiology of the disease.

  • Crohn's disease manifesting as an isolated cecal polyp and secondary appendiceal obstruction with histologically normal bowel. Gerada, Jurgen; Borg, Elaine; Cassar, Matthew; DeGaetano, James; LaFerla, Godfrey; Vassallo, Mario // International Journal of Colorectal Disease;Oct2014, Vol. 29 Issue 10, p1307 

    A letter to the editor is presented in response to the article "Crohn's disease manifesting as an isolated cecal polyp and secondary appendiceal obstruction with histologically normal bowel" in the May 21, 2014 issue.

  • Erratum to: Work disability and productivity loss in patients with inflammatory bowel diseases in Hungary in the era of biologics. Mandel, Michael; Bálint, Anita; Lovász, Barbara; Gulácsi, László; Strbák, Bálint; Golovics, Petra; Farkas, Klaudia; Kürti, Zsuzsanna; Szilágyi, Blanka; Mohás, Anna; Molnár, Tamás; Lakatos, Péter // European Journal of Health Economics;May2014 Supplement, Vol. 15, p129 

    A correction to the article "Work disability and productivity loss in patients with inflammatory bowel diseases in Hungary in the era of biologics" that was published in the May 29, 2014 issue is presented.

  • [sup 99m] Tc-interleukin-2 and [sup 99m] Tc-HMPAO granulocyte scintigraphy in patients with inactive Crohn's disease. Annovazzi, Alessio; Biancone, Livia; Caviglia, Renato; Chianelli, Marco; Capriotti, Gabriela; Mather, Stephen J.; Caprilli, Renzo; Pallone, Francesco; Scopinaro, Francesco; Signore, Alberto // European Journal of Nuclear Medicine & Molecular Imaging;2003, Vol. 30 Issue 3, p374 

    Crohn's disease (CD) is a chronic inflammatory bowel disease that may involve the whole gut. Marked intestinal T cell and macrophage activation is a key feature of the disease. Polymorphonuclear cell infiltration is also observed in the diseased gut, mainly during active inflammation....

  • Crohn's Disease. Ghosh, Sabitri; Rona, Zoltan // Alive: Canada's Natural Health & Wellness Magazine;Apr2003, Issue 246, p58 

    Deals with the inflammatory bowel disease called Crohn's disease. Incapacitation caused by it; Crohn's as an autoimmune disease arising from interplay of genetic factors and Western dietary habits; Management of the disease through diet and exercise; Stigma attached to the disease; Patients'...

  • Evaluation of disease extent with the Crohn's disease endoscopic index of severity. Marteau, Philippe // Gut;Dec2013, Vol. 62 Issue 12, p1819 

    A letter to the editor in response to the article "Mucosal healing in inflammatory bowel diseases: a systematic review" by M.F. Neurath and S.P. Travis in the 2012 issue is presented.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics