- Ulcerative colitis and Crohn's disease--susceptibility genes and clinical patterns. Jewell, Derek P. // Journal of Gastroenterology;1998, Vol. 33 Issue 3, p458
Reviews an article on susceptibility genes and clinical patterns of ulcerative colitis and Crohn's disease. Clinical observations suggesting genetic basis for the diseases; Details of the mode of inheritance of a complex disease; Discussion of genome searching in inflammatory bowel disease.
- Crohn's Disease Recurrence in Small Bowel Transplant. Glas, Jürgen; Folwaczny, Matthias; Folwaczny, Christian; Török, Helga-Paula // American Journal of Gastroenterology;Oct2004, Vol. 99 Issue 10, p2067
Presents a letter to the editor about the recurrence of Crohn's disease in a small bowel transplant.
- Genetic predisposition to Crohn disease due to mutations of the NOD2 gene. // European Journal of Pediatrics;2001, Vol. 160 Issue 11, p686
Presents a study which examined genetic predisposition to Crohn disease. Pathogenetic significance tumor necrosis factor signalling; Activation of nuclear factor kB in mononuclear cells; How the insertion mutation of NOD2 relates to susceptibility to Crohn disease.
- Susceptibility to Crohn's disease may lurk in enzyme mutation. // Journal of Medical Genetics;Nov2003, Vol. 40 Issue 11, p836
Discusses a preliminary study of genetic polymorphisms affecting transforming enzymes in the gut. Characterization of microsomal epoxide hydrolase as a likely candidate for susceptibility to Crohn's disease; Series of genes coding for detoxifying enzymes.
- Inflammatory bowel disease: Crohn's disease and the success of NODern genetics. Newman, Bill; Siminovitch, Katherine // Clinical & Investigative Medicine;Dec2003, Vol. 26 Issue 6, p303
The inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, are multifactorial in etiology, but a major causative role for genetic factors has long been recognized. Recent advances in genetic technologies have made dissection of the genes underlying common diseases possible;...
- Crohn's disease and the 'white plague': a hypothesis. Das, Kshaunish // Gut;Jun2014, Vol. 63 Issue 6, p1030
A letter to the editor is presented in response to the article "Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations" by S.K. Yang and colleagues in a 2014 issue.
- Molecular prediction of disease risk and severity in a large Dutch Crohnâ€™s disease cohort. R K Weersma // Gut;Mar2009, Vol. 58 Issue 3, p388
BACKGROUND: Crohnâ€™s disease and ulcerative colitis have a complex genetic background. We assessed the risk for both the development and severity of the disease by combining information from genetic variants associated with inflammatory bowel disease (IBD). METHODS: We studied 2804...
- Genome-wide association studies and Crohn’s disease. Lee, James C.; Parkes, Miles // Briefings in Functional Genomics;Mar2011, Vol. 10 Issue 2, p71
The development of genome-wide association scanning (GWAS) has revolutionized the search for genetic loci associated with complex diseases. Crohnâ€™s disease (CD), together with ulcerative colitis, has been a principal beneficiary of this technology with a recent meta-analysis from the...
- Slipping the barrier: how variants in CARD 15 could alter permeability of the intestinal wall and population health. Schreiber, S. // Gut;Mar2006, Vol. 55 Issue 3, p308
The increased intestinal permeability in Crohn's disease is associated with the presence of variants in the CARD15 gene that are regarded as causative for Crohn's disease, suggesting a genetic rather than an environmental background for intestinal Barrier dysfunction in Crohn's disease.
- Etiology of Crohn's disease: many roads lead to autophagy. Lapaquette, Pierre; Brest, Patrick; Hofman, Paul; Darfeuille-Michaud, Arlette // Journal of Molecular Medicine;Sep2012, Vol. 90 Issue 9, p987
Crohn's disease is a complex multifactor diseases that occur in individuals with genetic predisposition in whom environmental and microbial triggers cause a deleterious chronic immune response. Susceptibility to Crohn's disease is influenced by common variants at many loci. Genetic studies have...