Trichoepithelioma and Basal Cell Carcinoma with Squamous Diferentiation: Is it Causal or Coincidental?

Agarwal, Palak; Agarwal, Charu; Bhardwaj, Minakshi; Ahuja, Arvind; Rani, Seema
July 2015
Indian Journal of Dermatology;Jul/Aug2015, Vol. 60 Issue 4, p394
Academic Journal
Trichoepitheliomas (TEs) are benign cutaneous tumors that occur either as solitary non-familial or multiple familial. We report a case of multiple familial trichoepithelioma (MFT) in a 55-year-old female patient and her son who came with complaints of single ulcerated mass involving the left nasolabial fold and cheek. She had multiple papules and nodules all over the face and neck since 25 years. Histopathological examination of an ulcerated lesion revealed features of basal cell carcinoma (BCC) with squamous differentiation, which was confirmed by immunohistochemistry. A skin biopsy obtained from the papule on neck showed features of TE. However, whether BCC developed independently or by transformation from TE was uncertain. Her 36-year-old son presented with similar lesions on the face and a skin biopsy showed features of TE. Though malignant transformation of TE is quite rare, awareness of the potential for evolution of carcinoma in patients with MFT is important for management of these patients.


Related Articles

  • Multiple Familial Trichoepithelioma with Malignant Transformation. Samaka, Rehab M.; Bakry, Ola A.; Seleit, Iman; Abdelwahed, Moshira M.; Hassan, Rania A. // Indian Journal of Dermatology;Sep/Oct2013, Vol. 58 Issue 5, p467 

    Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin‑colored papules predominantly on the face. When more than one family member is affected, the disease is known as multiple familial trichoepithelioma (MFT). It is a rare autosomal dominant (AD) skin...

  • BASAL CELL ADENOMA OF THE SUBLINGUAL GLAND. Hsin-Ching Lin; Shun-Chen Huang, Börje; Chih-Yen Chien; Chih-Ying Su // Annals of Otology, Rhinology & Laryngology;Dec2003, Vol. 112 Issue 12, p1066 

    Salivary gland tumors constitute about 3% to 4% of all head and neck neoplasms. Approximately 80% originate in the parotid gland, and they rarely present in the sublingual gland; however, a disproportionately large majority of sublingual gland tumors are malignant. Basal cell adenoma is a benign...

  • Lesions Mimicking Melanoma at Dermoscopy Confirmed Basal Cell Carcinoma: Evaluation with Reflectance Confocal Microscopy. Peccerillo, Francesca; Mandel, Victor Desmond; Di Tullio, Francesca; Ciardo, Silvana; Chester, Johanna; Kaleci, Shaniko; de Carvalho, Nathalie; Del Duca, Ester; Giannetti, Luca; Mazzoni, Laura; Nisticò, Steven Paul; Stanganelli, Ignazio; Pellacani, Giovanni; Farnetani, Francesca; Mandel, Victor Desmond; Di Tullio, Francesca; de Carvalho, Nathalie; Del Duca, Ester; Nisticò, Steven Paul // Dermatology (10188665);Dec2018, Vol. 235 Issue 1, p35 

    Background: Atypical basal cell carcinoma (BCC), characterized by equivocal dermoscopic features typical of malignant melanoma (MM), can be difficult to diagnose. Reflectance confocal microscopy (RCM) enables in vivo imaging at nearly histological resolution.Objectives:...

  • In vivo Detection of Basal Cell Carcinoma using Imaging Spectroscopy. Wennberg, Ann-Marie; Gudmundson, Fredrik; Stenquist, Bo; Ternesten, Annika; Mölne, Lena; Rosén, Arne; Larkö, Olle // Acta Dermato-Venereologica;03/18/99, Vol. 79 Issue 1, p54 

    Photodynamic therapy has become an interesting alternative to conventional therapy for basal cell carcinomas. Delta-aminolevulinic acid is a precursor in the biosynthesis of protoporphyrin IX that accumulates to a large extent in tumour tissue. We have compared in vivo protoporphyrin IX...

  • Dermatology Digest. What is this slow-growing preauricular lesion? SHARMA, MALVEEKA; KHACHEMOUNE, AMOR // JAAPA: Journal of the American Academy of Physician Assistants (;Jun2011, Vol. 24 Issue 6, p20 

    The article presents a case study of a 78-year-old white male with a red lesion in his neck. It mentions that the patient had a history of sporadic sun exposure and a partner who is a smoker. The patient is diagnosed with superficial basal cell carcinoma (SBCC) with manifestations such as...

  • Reflectance Confocal Microscopy Features of Focal Dermal Mucinosis Differ from Those Described for Basal Cell Carcinoma: Report of Two Cases. Fraga-Braghiroli, Naiara abreu; Merati, Miesha; Rabinovitz, Harold; Swanson, David; Scope, alon // Dermatology (10188665);Nov2015, Vol. 231 Issue 4, p326 

    The purpose of this study was to describe the reflectance confocal microscopy (RCM) features of focal dermal mucinosis (FDM). The entity clinically and dermatoscopically mimics other diagnostic entities, most notably nonpigmented basal cell carcinoma. We describe two cases that highlight the...

  • Adenoid Type of Basal Cell Carcinoma: Rare Histopathological Variant at an Unusual Location. Tambe, Swagata A.; Ghate, Smita S.; Jerajani, Hemangi R. // Indian Journal of Dermatology;Mar/Apr2013, Vol. 58 Issue 2, following p159 

    Basal Cell Carcinoma (BCC) is almost exclusively seen in head.neck region with rare involvement of trunk and extremities. The tumour is commonly seen on nose, eyelids, at the inner canthus of eyes and behind the ears. Adenoid type of BCC is one of the rare histopathological types of BCC which...

  • Adenoid Basal Cell Carcinoma and its Mimics. Jetley, Sujata; Jairajpuri, Zeeba S.; Rana, Safia; Talikoti, Majid A. // Indian Journal of Dermatology;May/Jun2013, Vol. 58 Issue 3, p338 

    Basal cell carcinoma (BCC) is the most common malignant tumor of skin. The most common site (80%) is head and neck. BCC exhibits a varied morphology such as adenoid, keratotic, sebaceous, basosquamous, apocrine, eccrine or fibroepithelial. Tumors with a similar histopathological picture are...

  • Basal Cell Carcinoma and Syringocystadenoma Papilliferum Arising in Nevus Sebaceous on Face—A Rare Entity. Gupta, Sunil Kumar; Gupta, Vivek // Indian Journal of Dermatology;Nov/Dec2015, Vol. 60 Issue 6, p46 

    Nevus sebaceus of Jadassohn is a congenital cutaneous hamartoma comprising of multiple skin structures. It has the potential to develop into variety of neoplasms of various epidermal adnexal origins. While multiple tumors may occasionally arise, it is unusual to develop two different types of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics